From pyridinium-based to centrally active acetylcholinesterase reactivators

Mini-Reviews in Medicinal Chemistry

Volumn 14, Issue 3, 2014, Pages 215-221

  Korabecny, Jan ^a,b   Soukup, Ondrej ^b   Dolezal, Rafael ^b   Spilovska, Katarina ^a,b   Nepovimova, Eugenie ^a,b   Andrs, Martin ^a,b   Nguyen, Thuy Duong ^c   Jun, Daniel ^a,b   Musilek, Kamil ^a,b,d   Kucerova Chlupacova, Marta ^c   Kuca, Kamil ^b,d  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d UNIVERSITY OF HRADEC KRALOVE   (Czech Republic)

Author keywords

Acetylcholinesterase; HI 6; Organophosphorus compounds; Pralidoxime; Pyridinium oximes; Reactivator; Trimedoxime; Uncharged reactivator

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; ACETYLCHOLINESTERASE; ALDOXIME; AMIDINE OXIME; ARYLDIALKYLPHOSPHATASE; ATROPINE; BIS(PYRIDINIUM OXIME) DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; DIACYLMONOXIME; DIAZEPAM; DYFLOS; GALANTAMINE; GLUCOSE TRANSPORTER; ISONITROSOACETONE; MACROGOL; MONO PYRIDINIUM; OBIDOXIME; OXIME DERIVATIVE; PARAOXON; PHOSPHOTRIESTERASE; PRALIDOXIME; PYRIDINIUM DERIVATIVE; PYRIDOSTIGMINE; SARIN; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG BIOAVAILABILITY; HUMAN; INTOXICATION; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; POLYNEUROPATHY; PROTON NUCLEAR MAGNETIC RESONANCE; SURVIVAL RATE; ULTRAVIOLET SPECTROPHOTOMETRY; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM; ORGANOPHOSPHATE POISONING;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE REACTIVATORS; DRUG DISCOVERY; HUMANS; ORGANOPHOSPHATE POISONING; PYRIDINIUM COMPOUNDS;

EID: 84896368662     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557514666140219103138     Document Type: Article

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