Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 318-324

  Skovira, Jacob W ^a   O'Donnell, John C ^a   Koplovitz, Irwin ^a   Kan, Robert K ^a   McDonough, John H ^a   Shih, Tsung Ming ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acetylcholinesterase; Brain; Central nervous system; Cholinesterase reactivation; Cyclosarin; Guinea pig; Monoisonitrosoacetone; Nerve agents; Oximes; Pralidoxime; Protective ratio; Sarin; Survival; VX

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; ATROPINE METHYL NITRATE; CYCLOSARIN; ISONITROSOACETONE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OXIME DERIVATIVE; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BRAIN CORTEX; BRAIN STEM; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DIAPHRAGM; DRUG DOSE COMPARISON; DRUG EFFICACY; ENZYME REACTIVATION; GUINEA PIG; HEART; HIPPOCAMPUS; LD 50; MALE; MESENCEPHALON; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; SKELETAL MUSCLE; SPINAL CORD; SURVIVAL RATE;

ANIMALIA; CAVIA;

EID: 77955510195     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.010     Document Type: Article

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