New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19422-19430

  Sit, Rakesh K ^a   Radić, Zoran ^b   Gerardi, Valeria ^b   Zhang, Limin ^b   Garcia, Edzna ^b   Katalinić, Maja ^c   Amitai, Gabriel ^d   Kovarik, Zrinka ^c   Fokin, Valery V ^a   Sharpless, K Barry ^a   Taylor, Palmer ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ALDOXIMES; BLOOD-BRAIN BARRIER; BUTYRYLCHOLINESTERASE; CYCLOSARIN; IONIZATION STATE; NEW SERIES; NUCLEOPHILIC REACTIVITY; PARAOXON; PH DEPENDENCE; PH VALUE; PHYSIOLOGICAL PH; PROTONATED SPECIES; RANK ORDER; STRUCTURE-ACTIVITY; TERTIARY AMINE;

FUNCTIONAL GROUPS; PH;

RATE CONSTANTS;

ACETAMIDE DERIVATIVE; ACETONE; ACETYLTHIOCHOLINE; ALDOXIME; CHOLINESTERASE; CYCLOSARIN; DIACETYL OXIME; HYDROXYIMINO ACETAMIDE DERIVATIVE; IMIDAZOLE DERIVATIVE; ISONITROSOACETONE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OXIME DERIVATIVE; PARAOXON; SARIN; TERTIARY AMINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CELL PH; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME REACTIVATION; EXTRACELLULAR SPACE; IONIZATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; OXIMES; PHOSPHORIC ACID ESTERS; PHOSPHORYLATION;

EID: 79957583078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.230656     Document Type: Article

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