Novel oximes as blood-brain barrier penetrating cholinesterase reactivators

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 199-206

  Garcia, Gregory E ^a   Campbell, Amy J ^a   Olson, John ^a   Moorad Doctor, Deborah ^a   Morthole, Venee I ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Acetylcholinesterase; Blood brain barrier; Central nervous system; Organophosphates; Reactivation; Sugar oxime

Indexed keywords

CARBOHYDRATE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; DYFLOS; GLUCOSE TRANSPORTER; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; N [(3 BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 2 PYRIDINIUMALDOXIME CHLORIDE; N [(3 BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 3 PYRIDINIUMALDOXIME CHLORIDE; N [(3 BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 4 PYRIDINIUMALDOXIME CHLORIDE; N [3 (TETRA O BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 2 PYRIDINIUMALDOXIME CHLORIDE; N [3 (TETRA O BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 3 PYRIDINIUMALDOXIME CHLORIDE; N [3 (TETRA O BETA DEXTRO GLUCOPYRANOSYLOXY)OCTYL] 4 PYRIDINIUMALDOXIME CHLORIDE; ORGANOPHOSPHATE; OXIME; OXIME DERIVATIVE; PARAOXON; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME REACTIVATION; ERYTHROCYTE; HEART; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTOXICATION; LD 50; LIVER; MOUSE; NONHUMAN; SCIATIC NERVE; SINGLE DRUG DOSE; SKELETAL MUSCLE; TISSUE SECTION;

ANIMALIA; CAVIA;

EID: 77955508877     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.033     Document Type: Article

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