Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 11798-11809

  Radić, Zoran ^a   Sit, Rakesh K ^b   Kovarik, Zrinka ^c   Berend, Suzana ^c   Garcia, Edzna ^a   Zhang, Limin ^a   Amitai, Gabriel ^d   Green, Carol ^e   Radić, Božica ^c   Fokin, Valery V ^b   Sharpless, K Barry ^b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^e SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ALKYLAMINE; BLOOD-BRAIN BARRIER; CYCLOSARIN; IN-VITRO; INTRINSIC REACTIVITY; IONIZATION STATE; PARAOXON; PH DEPENDENCE; PHARMACOKINETIC PROPERTIES; PHARMACOKINETIC STUDIES; PRE-TREATMENT; UV VISIBLE SPECTROSCOPY;

HYDROLYSIS; MAMMALS; PHARMACOKINETICS; STRUCTURAL OPTIMIZATION; ULTRAVIOLET VISIBLE SPECTROSCOPY;

CATALYST ACTIVITY;

ACETYLCHOLINESTERASE; ATROPINE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; DIACETYL OXIME; ISONITROSOACETONE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; ORGANOPHOSPHATE; OXIME DERIVATIVE; PARAOXON; PRALIDOXIME IODIDE; RS 157A; RS 157B; RS 160C; RS 189A; RS 191E; RS 194B; RS 194C; RS 2 31B; RS 2 57B; RS 218A; RS 251A; RS 251B; RS 41A; RS 41B; RS 69L; RS 69N; SARIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG RETENTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME REACTIVATION; FEMALE; HYDROLYSIS; IN VITRO STUDY; INTOXICATION; IONIZATION; LD 50; MALE; MOUSE; NONHUMAN; NUCLEOPHILICITY; PH; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ACETAMIDES; ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; LETHAL DOSE 50; MICE; MOLECULAR STRUCTURE; OXIMES; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; REFERENCE STANDARDS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

MUS;

EID: 84859516990     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.333732     Document Type: Article

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