Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase

Toxicology Letters

Volumn 206, Issue 1, 2011, Pages 54-59

  de Koning, Martijn C ^a   van Grol, Marco ^a   Noort, Daan ^a  

^a TNO   (Netherlands)

Author keywords

Acetylcholinesterase; Nerve agent; Non quaternary oxime; Peripheral site; Reactivation

Indexed keywords

4 METHOXYPHENYL OXO ETHANALOXIME; ACETYLCHOLINESTERASE; CHOLINESTERASE REACTIVATOR; OXIME; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; DRUG CONJUGATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PURIFICATION;

ACETYLCHOLINESTERASE; BINDING SITES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; OXIMES; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 80051814613     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.04.004     Document Type: Article

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