Treatment with tertiary oximes prevents seizures and improves survival following sarin intoxication

Journal of Molecular Neuroscience

Volumn 40, Issue 1-2, 2010, Pages 63-69

  Shih, Tsung Ming ^a   Skovira, Jacob W ^a   O'Donnell, John C ^a   McDonough, John H ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acetylcholinesterase; Anticonvulsant; Oxime reactivator; Sarin; Seizures; Tertiary oxime

Indexed keywords

1,1' METHYLENEBIS(4 HYDROXYIMINOMETHYLPYRIDINIUM) DICHLORIDE; ACETYLCHOLINESTERASE; ATROPINE; DIACETYL OXIME; HLO7; ISONITROSOACETONE; OXIME; PYRIDINE 2 ALDOXIME METHYL CHLORIDE; PYRIDOSTIGMINE; SARIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; BLOOD; BRAIN REGION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GUINEA PIG; MALE; NONHUMAN; PROVOCATION TEST; SEIZURE; SURVIVAL RATE;

ACETYLCHOLINESTERASE; ANIMALS; ATROPINE; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DIACETYL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; GUINEA PIGS; INJECTIONS, INTRAMUSCULAR; MALE; MUSCARINIC ANTAGONISTS; OXIMES; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; PYRIDOSTIGMINE BROMIDE; SARIN; SEIZURES; TREATMENT OUTCOME; UP-REGULATION;

ANIMALIA; CAVIA;

EID: 75049084488     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-009-9259-7     Document Type: Conference Paper

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