A structure-activity analysis of the variation in oxime efficacy against nerve agents

Toxicology and Applied Pharmacology

Volumn 231, Issue 2, 2008, Pages 157-164

  Maxwell, Donald M ^a   Koplovitz, Irwin ^a   Worek, Franz ^b   Sweeney, Richard E ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; Organophosphorus nerve agents; Oxime; Steric hindrance

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ATROPINE; CYCLOSARIN; ICD 585; ISONICOTINAMIDE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; O ISOBUTYL S [2 (DIETHYLAMINO)ETHYL]METHYLPHOSPHONOTHIOATE; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PRALIDOXIME; SARIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG STRUCTURE; ERYTHROCYTE; GUINEA PIG; MALE; NONHUMAN; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; ATROPINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; ERYTHROCYTES; GUINEA PIGS; LINEAR MODELS; MALE; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; OXIMES; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS; SARIN; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA;

EID: 49549113611     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.04.007     Document Type: Article

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