Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10791-10795

  Mercey, Guillaume ^a,b,c,d   Renou, Julien ^a,b,c,d   Verdelet, Tristan ^a,b,c,d   Kliachyna, Maria ^e   Baati, Rachid ^e   Gillon, Emilie ^c,d   Arboléas, Mélanie ^c,d   Loiodice, Mélanie ^c,d   Nachon, Florian ^c,d   Jean, Ludovic ^a,b,c,d   Renard, Pierre Yves ^a,b,c,d  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ ET INSA DE ROUEN   (France)

^c CNRS Delegation Normandie   (France)

^d INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^e UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6[6(6,7 DIMETHOXY 1 PHENYL 3,4 DIHYDROISOQUINOLIN 2(1H) YL)HEXYL] 3 HYDROXYPICOLINALDEHYDE OXIME; ACETYLCHOLINESTERASE; ALDOXIME; CHOLINESTERASE REACTIVATOR; ETHYLPARAOXON; ISOQUINOLINE DERIVATIVE; OXIME; PARAOXON; PHENYLTETRAHYDROISOQUINOLINE PYRIDINALDOXIME; PYRIDINIUM DERIVATIVE; TABUN; UNCLASSIFIED DRUG; VX PARAOXON;

ARTICLE; CONJUGATION; DEPHOSPHORYLATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME REACTIVATION; IC 50; PROTEIN DEPHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; ENZYME REACTIVATORS; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; OXIMES; PHOSPHORYLATION;

EID: 84871016585     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3015519     Document Type: Article

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