-
1
-
-
79951847547
-
-
Nicolaou, K. C., Hanko, R., Hartwig, W., Eds.; Wiley-VCH: Weinheim, Germany
-
Nicolaou, K. C.; Hanko, R.; Hartwig, W. In Handbook of Combinatorial Chemistry; Nicolaou, K. C., Hanko, R., Hartwig, W., Eds.; Wiley-VCH: Weinheim, Germany, 2002; Vol. 1, pp 3-9.
-
(2002)
Handbook of Combinatorial Chemistry
, vol.1
, pp. 3-9
-
-
Nicolaou, K.C.1
Hanko, R.2
Hartwig, W.3
-
7
-
-
0037362544
-
-
Geysen, H. M.; Schoenen, F.; Wagner, D.; Wagner, R. Nat. Rev. Drug Discovery 2003, 2, 222-230.
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, pp. 222-230
-
-
Geysen, H.M.1
Schoenen, F.2
Wagner, D.3
Wagner, R.4
-
8
-
-
27744554825
-
Fixing the drugs pipeline
-
March 11
-
Fixing the drugs pipeline. The Economist, March 11, 2004; available online at http://www.economist.com/printedition/displayStory.cfm?Story_ID= 2477075.
-
(2004)
The Economist
-
-
-
10
-
-
0022469902
-
-
Rideout, D. Science 1986, 233, 561-563.
-
(1986)
Science
, vol.233
, pp. 561-563
-
-
Rideout, D.1
-
11
-
-
0025117445
-
-
Rideout, D.; Calogeropoulou, T.; Jaworski, J.; McCarthy, M. Biopolymers 1990, 29, 247-262.
-
(1990)
Biopolymers
, vol.29
, pp. 247-262
-
-
Rideout, D.1
Calogeropoulou, T.2
Jaworski, J.3
McCarthy, M.4
-
15
-
-
0035382539
-
-
Bunyapaiboonsri, T.; Ramstrom, O.; Lohmann, S.; Lehn, J.-M.; Peng, L.; Goeldner, M. ChemBioChem 2001, 2, 438-444.
-
(2001)
ChemBioChem
, vol.2
, pp. 438-444
-
-
Bunyapaiboonsri, T.1
Ramstrom, O.2
Lohmann, S.3
Lehn, J.-M.4
Peng, L.5
Goeldner, M.6
-
19
-
-
0034662911
-
-
Erlanson, D. A.; Braisted, A. C.; Raphael, D. R.; Randal, M.; Stroud, R. M.; Gordon, E. M.; Wells, J. A. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 9367-9372.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 9367-9372
-
-
Erlanson, D.A.1
Braisted, A.C.2
Raphael, D.R.3
Randal, M.4
Stroud, R.M.5
Gordon, E.M.6
Wells, J.A.7
-
20
-
-
0037337035
-
-
Erlanson, D. A.; Lam, J. W.; Wiesmann, C.; Luong, T. N.; Simmons, R. L.; DeLano, W. L.; Choong, I. C.; Burden, M. T.; Flanagan, W. M.; Lee, D.; Gordon, E. M.; O'Brien, T. Nat. Biotechnol. 2003, 21, 308-314.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 308-314
-
-
Erlanson, D.A.1
Lam, J.W.2
Wiesmann, C.3
Luong, T.N.4
Simmons, R.L.5
DeLano, W.L.6
Choong, I.C.7
Burden, M.T.8
Flanagan, W.M.9
Lee, D.10
Gordon, E.M.11
O'Brien, T.12
-
21
-
-
1842784768
-
-
Ramström, O.; Lohmann, S.; Bunyapaiboonsri, T.; Lehn, J.-M. Chem.-Eur. J. 2004, 10, 1711-1715.
-
(2004)
Chem.-Eur. J.
, vol.10
, pp. 1711-1715
-
-
Ramström, O.1
Lohmann, S.2
Bunyapaiboonsri, T.3
Lehn, J.-M.4
-
23
-
-
0037059901
-
-
Kehoe, J. W.; Maly, D. J.; Verdugo, D. E.; Armstrong, J. I.; Cook, B. N.; Ouyang, Y.-B.; Moore, K. L.; Ellman, J. A.; Bertozzi, C. R. Bioorg. Med. Chem. Lett. 2002, 12, 329-332.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 329-332
-
-
Kehoe, J.W.1
Maly, D.J.2
Verdugo, D.E.3
Armstrong, J.I.4
Cook, B.N.5
Ouyang, Y.-B.6
Moore, K.L.7
Ellman, J.A.8
Bertozzi, C.R.9
-
24
-
-
0037087516
-
-
Lewis, W. G.; Green, L. G.; Grynszpan, F.; Radic, Z.; Carlier, P. R.; Taylor, P.; Finn, M. G.; Sharpless, K. B. Angew. Chem., Int. Ed. 2002, 41, 1053-1057.
-
(2002)
Angew. Chem., Int. Ed.
, vol.41
, pp. 1053-1057
-
-
Lewis, W.G.1
Green, L.G.2
Grynszpan, F.3
Radic, Z.4
Carlier, P.R.5
Taylor, P.6
Finn, M.G.7
Sharpless, K.B.8
-
25
-
-
1242342257
-
-
Bourne, Y.; Kolb, H. C.; Radiç, Z.; Sharpless, K. B.; Taylor. P.; Marchot, P. Proc. Natl. Acad. Sci., U.S.A. 2004, 101, 1449-1454.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 1449-1454
-
-
Bourne, Y.1
Kolb, H.C.2
Radiç, Z.3
Sharpless, K.B.4
Taylor, P.5
Marchot, P.6
-
27
-
-
0030852355
-
-
Boger, D. L.; Haynes, N.-E.; Kitos, P. A.; Warren, M. S.; Ramcharan, J.; Marolewski, A. E.; Benkovic, S. J. Bioorgan. Med. Chem. 1997, 5, 1817-1830.
-
(1997)
Bioorgan. Med. Chem.
, vol.5
, pp. 1817-1830
-
-
Boger, D.L.1
Haynes, N.-E.2
Kitos, P.A.3
Warren, M.S.4
Ramcharan, J.5
Marolewski, A.E.6
Benkovic, S.J.7
-
28
-
-
0035856543
-
-
Greasley, S. E.; Marsilje, T. H.; Cai, H.; Baker, S.; Benkovic, S. J.; Boger, D. L.; Wilson, I. A. Biochemistry 2001, 40, 13538-13547.
-
(2001)
Biochemistry
, vol.40
, pp. 13538-13547
-
-
Greasley, S.E.1
Marsilje, T.H.2
Cai, H.3
Baker, S.4
Benkovic, S.J.5
Boger, D.L.6
Wilson, I.A.7
-
29
-
-
0035805266
-
-
Nguyen, R.; Huc, I. Angew. Chem., Int. Ed. 2001, 40, 1774-1776.
-
(2001)
Angew. Chem., Int. Ed.
, vol.40
, pp. 1774-1776
-
-
Nguyen, R.1
Huc, I.2
-
30
-
-
0034602053
-
-
Nicolaou, K. C.; Hughes, R.; Cho, S. Y.; Winssinger, N.; Smethurst, C.; Labischinski, H.; Endermann, R. Angew. Chem., Int. Ed. 2000, 39, 3823-3828.
-
(2000)
Angew. Chem., Int. Ed.
, vol.39
, pp. 3823-3828
-
-
Nicolaou, K.C.1
Hughes, R.2
Cho, S.Y.3
Winssinger, N.4
Smethurst, C.5
Labischinski, H.6
Endermann, R.7
-
31
-
-
0035801386
-
-
Nicolaou, K. C.; Hughes, R.; Cho, S. Y.; Winssinger, N.; Labischinski, H.; Endermann, R. Chem.-Eur. J. 2001, 7, 3824-3843.
-
(2001)
Chem.-Eur. J.
, vol.7
, pp. 3824-3843
-
-
Nicolaou, K.C.1
Hughes, R.2
Cho, S.Y.3
Winssinger, N.4
Labischinski, H.5
Endermann, R.6
-
32
-
-
0002490493
-
-
Padwa, A., Ed.; Wiley: New York
-
Huisgen, R. In 1,3-Dipolar Cycloaddition Chemistry; Padwa, A., Ed.; Wiley: New York, 1984; Vol. 1, pp 1-176.
-
(1984)
1,3-Dipolar Cycloaddition Chemistry
, vol.1
, pp. 1-176
-
-
Huisgen, R.1
-
33
-
-
0000350612
-
-
Mock, W. L.; Irra, T. A.; Wepsiec, J. P.; Manimaran, T. L. J. Org. Chem. 1983, 48, 3619-3620.
-
(1983)
J. Org. Chem.
, vol.48
, pp. 3619-3620
-
-
Mock, W.L.1
Irra, T.A.2
Wepsiec, J.P.3
Manimaran, T.L.4
-
34
-
-
0001333572
-
-
Mock, W. L.; Irra, T. A.; Wepsiec, J. P.; Adhya, M. J. Org. Chem. 1989, 54, 5302-5308.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 5302-5308
-
-
Mock, W.L.1
Irra, T.A.2
Wepsiec, J.P.3
Adhya, M.4
-
39
-
-
0025778840
-
-
Sussman, J. L.; Harel, M.; Frolow, F.; Oefner, C.; Goldman, A.; Toker, L.; Silman, I. Science 1991, 253, 872-879.
-
(1991)
Science
, vol.253
, pp. 872-879
-
-
Sussman, J.L.1
Harel, M.2
Frolow, F.3
Oefner, C.4
Goldman, A.5
Toker, L.6
Silman, I.7
-
40
-
-
0027368530
-
-
Harel, M.; Schalk, I.; Ehret-Sabatier, L.; Bouet, F.; Goeldner, M.; Hirth, C.; Axelsen, P. H.; Silman, I.; Sussman, J. L. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 9031-9035.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 9031-9035
-
-
Harel, M.1
Schalk, I.2
Ehret-Sabatier, L.3
Bouet, F.4
Goeldner, M.5
Hirth, C.6
Axelsen, P.H.7
Silman, I.8
Sussman, J.L.9
-
41
-
-
0345188660
-
-
Wei, J.; Buriak, J. M.; Siuzdak, G. Nature 1999, 399, 243-246.
-
(1999)
Nature
, vol.399
, pp. 243-246
-
-
Wei, J.1
Buriak, J.M.2
Siuzdak, G.3
-
42
-
-
85039510043
-
-
note
-
-1 24). Apart from the expected entropic stabilization, the transition state may also experience stabilization through hydrogen bonding and stacking interactions with the protein.25
-
-
-
-
43
-
-
85039503167
-
-
note
-
The in situ screening experiments were generally performed with the following concentrations: 1 μM for the enzyme, 4.6 μM for tacrine components, and 24 μM for phenylphenanthridinium components. Because of the sensitive nature of the analysis method, the building block concentrations can be reduced to as low as 1 μM for tacrine reagents and 6 μM for phenylphenanthridinium reagents, without a significant loss of intensity of the product peak. However, lowering the phenylphenanthridinium component concentration to 1 μM dramatically decreased the reaction rate and makes the intensity of the product signal prohibitively small.
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-
-
-
44
-
-
85039492202
-
-
note
-
The computation was performed at the Swiss Institute of Bioinformatics (SIB) using the BLAST network service. The SIB BLAST network service uses a server developed at SIB and the National Center for Biotechnology Information (NCBI) BLAST 2 software.
-
-
-
-
45
-
-
0030801002
-
-
Altschul, S. F.; Madden, T. L.; Schäffer, A. A.; Zhang, J.; Zhang, Z.; Miller, W.; Lipman, D. J. Nucleic Acids Res. 1997, 25, 3389-3402.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
46
-
-
0037099395
-
-
Rostovtsev, V. V.; Green. L. G.; Fokin, V. V.; Sharpless, K. B. Angew. Chem., Int. Ed. 2002, 41, 2596-2599.
-
(2002)
Angew. Chem., Int. Ed.
, vol.41
, pp. 2596-2599
-
-
Rostovtsev, V.V.1
Green, L.G.2
Fokin, V.V.3
Sharpless, K.B.4
-
47
-
-
0037012920
-
-
Tornøe, C. W.; Christensen, C.; Meldal, M. J. Org. Chem. 2002, 67, 3057-3064.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 3057-3064
-
-
Tornøe, C.W.1
Christensen, C.2
Meldal, M.3
-
48
-
-
85039502697
-
-
note
-
All samples were analyzed by LC/MS-SIM with electrospray detection on a Cyclobond 1 2000 DMP column (4.6 × 100 mm, preceded by a Phenomenex C18 ODS guard column) using isocratic elution conditions.
-
-
-
-
49
-
-
0027517144
-
-
Radic, Z.; Pickering, N. A.; Vellom, D. C.; Camp, S.; Taylor, P. Biochemistry 1993, 32, 12074-12084.
-
(1993)
Biochemistry
, vol.32
, pp. 12074-12084
-
-
Radic, Z.1
Pickering, N.A.2
Vellom, D.C.3
Camp, S.4
Taylor, P.5
-
50
-
-
0029874624
-
-
Marchot, P.; Ravelli, R. B. G.; Raves, M. L.; Bourne, Y.; Vellom, D. C.; Kanter, J.; Camp, S.; Sussman, J. L.; Taylor, P. Protein Sci. 1996, 5, 672-679.
-
(1996)
Protein Sci.
, vol.5
, pp. 672-679
-
-
Marchot, P.1
Ravelli, R.B.G.2
Raves, M.L.3
Bourne, Y.4
Vellom, D.C.5
Kanter, J.6
Camp, S.7
Sussman, J.L.8
Taylor, P.9
-
52
-
-
33644811612
-
-
Ellman, G. L.; Courtney, K. D.; Valentino Andres, J.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88-95.
-
(1961)
Biochem. Pharmacol.
, vol.7
, pp. 88-95
-
-
Ellman, G.L.1
Courtney, K.D.2
Valentino Andres, J.3
Featherstone, R.M.4
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