Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 67-71

  Radić, Zoran ^a   Sit, Rakesh K ^b   Garcia, Edzna ^a   Zhang, Limin ^a   Berend, Suzana ^c   Kovarik, Zrinka ^c   Amitai, Gabriel ^d   Fokin, Valery V ^b   Barry Sharpless, K ^b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

CNS AChE reactivation; Molecular modeling; Organophosphate intoxication; Oxime reactivation; Peripheral site

Indexed keywords

ALIPHATIC AMINE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OXIME DERIVATIVE; PARAOXON; PYRIDINIUM DERIVATIVE; SARIN; TABUN;

BINDING KINETICS; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; CONFERENCE PAPER; CONJUGATE; COVALENT BOND; MICHAELIS CONSTANT; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PHOSPHORYLATION;

ACETAMIDES; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; GPI-LINKED PROTEINS; HUMANS; KINETICS; MODELS, MOLECULAR; ORGANOPHOSPHATES; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PARAOXON; SARIN;

EID: 84875809406     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.014     Document Type: Conference Paper

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