Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Aβ1-42 aggregation for Alzheimer's disease therapeutics

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 20, 2007, Pages 6596-6607

  Kwon, Young Ee ^a   Park, Jung Youl ^b   No, Kyung Tai ^c,d   Shin, Jae Hong ^d   Lee, Sung Kwang ^d   Eun, Jae Soon ^a   Yang, Jae Heon ^a   Shin, Tae Yong ^a   Kim, Dae Keun ^a   Chae, Byung Sook ^a   Leem, Jae Yoon ^a   Kim, Kuk Hwan ^e  

^a Woosuk University   (South Korea)

^b C and C Research Laboratories   (South Korea)

^c Yonsei University   (South Korea)

^d Bioinformatics and Molecular Design Research Center (BMDRC)   (South Korea)

^e K and C Medicine Research Center   (South Korea)

Author keywords

A 1 42 aggregation; Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Dual action; Piperidine derivatives

Indexed keywords

4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 3 CHLOROBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 3 FLUOROBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 4 (TERT BUTYL)BENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 4 CHLOROBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 4 FLUOROBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 4 ISOPROPYLBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL 4 NITROBENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL BENZOATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL N (4 CHLOROPHENYL)CARBAMATE; 4 [4 (BENZHYDRYLOXY)PIPERIDINO]BUTYL N (4 FLUOROPHENYL)CARBAMATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 3 CHLOROBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 3 FLUOROBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 4 (TERT BUTYL)BENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 4 CHLOROBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 4 FLUOROBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 4 ISOPROPYLBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL 4 NITROBENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL BENZOATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL N (4 CHLOROPHENYL)CARBAMATE; 4 [4 (BENZYLOXY)PIPERIDINO]BUTYL N (4 FLUOROPHENYL)CARBAMATE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-42]; BENZOIC ACID; CHOLINESTERASE; DONEPEZIL; GALANTAMINE; PIPERIDINE DERIVATIVE; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN CONFORMATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BUTYRYLCHOLINESTERASE; CELL LINE; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; HUMANS; INDANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE FRAGMENTS; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548124528     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.003     Document Type: Article

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