Autoregulation of free radicals via uncoupling protein control in pancreatic β-cell mitochondria

Biophysical Journal

Volumn 98, Issue 2, 2010, Pages 207-217

  Heuett, William J ^a   Periwal, Vipul ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77049113232     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.10.012     Document Type: Article

References (32)

1. Lambert, A. J., and M. D. Brand. 2009. Reactive oxygen species production in mitochondria. Methods in Molecular Biology, Vol.554. Humana Press, Totowa, NJ.
2. Brownlee, M. 2005. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 54:1615-1625.
3. Wallace, D. C. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39:359-407.
4. Spiegelman, B. M. 2007. Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Found. Symp. 287:60-63, discussion 63-69.
5. Balaban, R. S., S. Nemoto, and T. Finkel. 2005. Mitochondria, oxidants, and aging. Cell. 120:483-495.
6. Guarente, L. 2008. Mitochondria-a nexus for aging, calorie restriction, and sirtuins? Cell. 132:171-176.
7. Twig, G., A. Elorza,., O. S. Shirihai. 2008. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 27:433-446.
8. Pi, J., Y. Bai,., S. Collins. 2009. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β-cell function. Endocrinology. 150:3040-3048.
9. Leloup, C., C. Tourrel-Cuzin,., L. Pénicaud. 2009. Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes. 58:673-681.
10. Zhang, C.-Y., G. Baffy,., B. B. Lowell. 2001. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes. Cell. 105: 745-755.
11. Lameloise, N., P. Muzzin,., F. Assimacopoulos-Jeannet. 2001. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes. 50: 803-809.
12. Brownlee, M. 2003. A radical explanation for glucose-induced β-cell dysfunction. J. Clin. Invest. 112:1788-1790.
13. Krauss, S., C.-Y. Zhang,., B. B. Lowell. 2003. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β-cell dysfunction. J. Clin. Invest. 112:1831-1842.
14. Lowell, B. B., and G. I. Shulman. 2005. Mitochondrial dysfunction and type 2 diabetes. Science. 307:384-387.
15. McCormack, J. G., A. P. Halestrap, and R. M. Denton. 1990. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol. Rev. 70:391-425.
16. Bertram, R., M. Gram Pedersen,., A. Sherman. 2006. A simplified model for mitochondrial ATP production. J. Theor. Biol. 243:575-586.
17. Andreyev, A. Y., Y. E. Kushnareva, and A. A. Starkov. 2005. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc.). 70:200-214.
18. Affourtit, C., and M. D. Brand. 2008. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem. J. 409:199-204.
19. Affourtit, C., and M. D. Brand. 2006. Stronger control of ATP/ADP by proton leak in pancreatic β-cells than skeletal muscle mitochondria. Biochem. J. 393:151-159.
20. Echtay, K. S., D. Roussel,., M. D. Brand. 2002. Superoxide activates mitochondrial uncoupling proteins. Nature. 415:96-99.
21. Esteves, T. C., and M. D. Brand. 2005. The reactions catalyzed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim. Biophys. Acta. 1709:35-44.
22. Parker, N., C. Affourtit,., M. D. Brand. 2008. Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem. J. 412:131-139.
23. 2+ handling. Am. J. Physiol. 273:C717-C733.
24. Cortassa, S., M. A. Aon,., B. O'Rourke. 2003. An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J. 84:2734-2755.
25. Magnus, G., and J. Keizer. 1998. Model of β-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables. Am. J. Physiol. 274:C1158-C1173.
26. Hearn, A. S., E. Stroupe,., D. N. Silverman. 2001. Kinetic analysis of product inhibition in human manganese superoxide dismutase. Biochemistry. 40:12051-12058.
27. Lehninger, A. 1975. In Biochemistry., 2nd Ed. Worth Publishers, New York.
28. 2 in cells and thereby their biological state. Free Radic. Biol. Med. 41: 1338-1350.
29. Azzu, V., C. Affourtit,., M. D. Brand. 2008. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim. Biophys. Acta. 1777:1378-1383.
30. Petersen, K. F., and G. I. Shulman. 2006. New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy. Obesity (Silver Spring). 14 (Suppl 1):34S-40S.
31. Breda, E., M. K. Cavaghan,., C. Cobelli. 2001. Oral glucose tolerance test minimal model indexes of β-cell function and insulin sensitivity. Diabetes. 50:150-158.
32. Zhang, C. Y., L. E. Parton,., B. B. Lowell. 2006. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β-cell dysfunction in isolated pancreatic islets. Cell Metab. 3:417-427.