Deceleration of fusion-fission cycles improves mitochondrial quality control during aging

PLoS Computational Biology

Volumn 8, Issue 6, 2012, Pages

  Figge, Marc Thilo ^a,b,c   Reichert, Andreas S ^d,e   Meyer Hermann, Michael ^b,c   Osiewacz, Heinz D ^d  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRANKFURT INSTITUTE FOR ADVANCED STUDIES   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d GOETHE UNIVERSITY   (Germany)

^e Buchmann Institute for Molecular Life Sciences   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; QUALITY ASSURANCE;

'CURRENT; FUSION-FISSION; IN-SILICO; LIFESPANS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; MITOCHONDRIAS; MODELING APPROACH; MOLECULAR DAMAGE; PROBABILISTIC MODELS;

QUALITY CONTROL;

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ARTICLE; BIOGENESIS; CELL AGING; CELL FISSION; CELL FUSION; CELL RENEWAL; CELLULAR PARAMETERS; COMPUTER SIMULATION; DECELERATION; EVOLUTIONARY ADAPTATION; HOMEOSTASIS; LIFE CYCLE; LIFE EXTENSION; LIFESPAN; MEMBRANE DAMAGE; MITOCHONDRIAL INFECTIOUS DAMAGE ADAPTATION MODEL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR WEIGHT; OXIDATIVE STRESS; PROBABILITY; STEADY STATE; AGING; ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; BIOLOGY; DEGENERATIVE DISEASE; ENERGY METABOLISM; HUMAN; MEMBRANE FUSION; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; SYSTEMS BIOLOGY;

FUNGI;

AGING; ANIMALS; AUTOPHAGY; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ENERGY METABOLISM; HUMANS; MEMBRANE FUSION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; REACTIVE OXYGEN SPECIES; SYSTEMS BIOLOGY;

EID: 84864061186     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002576     Document Type: Article

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