Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice

Diabetologia

Volumn 57, Issue 2, 2014, Pages 352-361

  Yang, Kai Ting ^a   Bayan, Jennifer Ann ^a   Zeng, Ni ^a   Aggarwal, Richa ^a   He, Lina ^a   Peng, Zhechu ^a   Kassa, Anketse ^a   Kim, Melissa ^a   Luo, Zhiou ^a   Shi, Zhenrong ^a   Medina, Vivian ^a   Boddupally, Keerthi ^a   Stiles, Bangyan L ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adult beta cells; PTEN; Regeneration; RIP CreER

Indexed keywords

CRE RECOMBINASE; CYCLIN D1; CYCLIN D2; GLUCOSE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P16; PROTEIN P27; RAT INSULIN PROMOTER; UNCLASSIFIED DRUG;

ADULT ONSET DELETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL CYCLE REGULATION; CELL PROLIFERATION; DNA ISOLATION; DOWN REGULATION; EMBRYO DEVELOPMENT; EXPERIMENTAL MOUSE; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MASS; MITOGENESIS; MITOSIS RATE; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET CELL MASS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN ISOLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

AGING; ANIMALS; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DNA METHYLATION; DOWN-REGULATION; GENE DELETION; HOMEOSTASIS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, MUTANT STRAINS; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84893690149     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3085-8     Document Type: Article

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