IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

Diabetologia

Volumn 51, Issue 10, 2008, Pages 1862-1872

  Agudo, J ^a,b   Ayuso, E ^a,b   Jimenez, V ^a,b   Salavert, A ^a   Casellas, A ^a,b   Tafuro, S ^a,b   Haurigot, V ^a,b   Ruberte, J ^a,b   Segovia, J C ^c,d   Bueren, J ^c,d   Bosch, F ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c CIEMAT   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Beta cells; Bone marrow derived cells; Cell cycle; Islet regeneration; Replication

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GREEN FLUORESCENT PROTEIN; INSULIN; MONOCLONAL ANTIBODY KI 67; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL DIVISION; CELL REGENERATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BLOTTING, WESTERN; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOZOCIN;

EID: 51249114293     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1087-8     Document Type: Article

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