PTEN controls β-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a

Aging Cell

Volumn 12, Issue 6, 2013, Pages 1000-1011

  Zeng, Ni ^a   Yang, Kai Ting ^b   Bayan, Jennifer Ann ^a   He, Lina ^a   Aggarwal, Richa ^a   Stiles, Joseph W ^a   Hou, Xiaogang ^a   Medina, Vivian ^a   Abad, Danny ^c   Palian, Beth M ^b   Al Abdullah, Ismail ^c   Kandeel, Fouad ^c   Johnson, Deborah L ^b   Stiles, Bangyan L ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c Islet Transplant Center   (United States)

Author keywords

cells; Aging; P16ink4a; PI3K; PTEN

Indexed keywords

CYCLIN D1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P16; SOMATOMEDIN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR EZH2;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL CYCLE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN METHYLATION; SENESCENCE; UPREGULATION;

ANIMALIA; MUS;

AGING; P16INK4A; PI3K; PTEN; Β-CELLS;

AGING; ANIMALS; CELL CYCLE; CELL PROLIFERATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA METHYLATION; DOWN-REGULATION; GENE DELETION; HUMANS; INSULIN-SECRETING CELLS; MICE; POLYCOMB REPRESSIVE COMPLEX 2; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84888132535     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12132     Document Type: Article

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