The SCID mouse mutant: Definition and potential use as a model for immune and hematological disorders

Hematology and Cell Therapy

Volumn 39, Issue 5, 1997, Pages 213-221

  Leblond, V ^a   Autran, B ^a   Cesbron, J Y ^b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Hematological disorders; Immunological disorders; SCID mice

Indexed keywords

ANIMAL MODEL; B LYMPHOCYTE; BONE MARROW TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; EPSTEIN BARR VIRUS; HEMATOPOIESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; LEUKEMOGENESIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; REVIEW; T LYMPHOCYTE;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; HEMATOLOGIC DISEASES; HUMANS; IMMUNE SYSTEM DISEASES; LYMPHOCYTES; MICE; MICE, SCID; SEVERE COMBINED IMMUNODEFICIENCY; SPECIES SPECIFICITY;

EID: 0030828519     PISSN: 12693286     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00282-997-0213-2     Document Type: Review

References (102)

1. Aaberge IS, Steinsvik TE, Groeng EC, et al. (1990) Human antibody response to a pneumococcal vaccine in SCID-PBL-hu mice and simultaneously vaccinated human cell donors. Clin Exp Immunol 105:12-17
2. Abedi MR, Christensson B, Islam KB, et al. (1992) Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells. Eur J Immunol 22: 823-828
3. Akkina RK, Rosenblatt JD, Campbell AG, et al. (1994) Modeling human lymphoid precursor cell gene therapy in the SCID-hu mouse. Blood 84: 1393-1398
4. Autran B, Guiet P, Raphael M, et al. (1996) Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model. AIDS 10: 717-727
5. Auwaerter PG, Kaneshima H, Mccune JM, et al. (1996) Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. J Virol 70: 3734-3740
6. Baccala R, Vandekerckhove BAE, Jones D, et al. (1993) Bacterial superantigens mediate T-cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model. J Exp Med 177: 1481-1485
7. Baiocchi RA, Ross ME, Tan JC, et al. (1995) Lymphomagenesis in the SCID-hu mouse involves abundant production of human interleukin-10. Blood 85: 1063-1074
8. Banga SS, Hall KT, Sandhu AK, et al. (1994) Complementation of V(D)J recombination defect and X-ray sensitivity of SCID mouse cells by human chromosome 8. Muta Res DNA Repair 315: 239-247
9. Barry TS, Jones DM, Richter CB, et al (1991) Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. J Exp Med 173: 167-180
10. Baum CM, Weissman IL, Tsukamoto AS, et al. (1992) Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89: 2804-2808
11. Biedermann KA, Sun JR, Giaccia AJ, et al. (1991) SCID mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci USA 88: 1394-1397
12. Blackwell TK, Ferrier P, Malynn BA, et al. (1989) The effect of the SCID mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Curr Top Microbiol Immunol 152: 85-94
13. Bombil F, Kints JP, Scheiff JM, et al. (1996) A promising model of primary human immunization in human-SCID mouse. Immunobiology 195: 360-375
14. Bosma GC, Custer RP, Bosma MJ (1983) A severe combined immunodeficiency mutation in the mouse. Nature 301: 527-530
15. Bosma GC, Fried M, Custer RP, et al. (1988) Evidence of functional lymphocytes in some (leaky) SCID mice. J Exp Med 167: 1016-1033
16. Bosma MJ, Carroll AM (1991) The SCID mouse mutant definition, characterization, and potential uses. Annu Rev Immunol 9: 323-350
17. Cadore B, Puech F, Cesbron JY (1995) Ethics and fetal experimental grafts of tissue on SCID/SCID mice. MS-Med Sci 11: 755-760
18. Cesano A, Hoxie JA, Lange B, et al. (1992) The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias. Oncogene 7: 827-836
19. Cesano A, O'Connor R, Lange B, et al. (1991) Homing and progression patterns of childhood acute lymphoblastic leukemias in severe combined immunodeficiency mice. Blood 77: 2463-2474
20. Cesano A, Visonneau S, Cioe L, et al. (1994) Reversal of acute myelogenous leukemia in humanized SCID mice using a novel adoptive transfer approach. J Clin Invest 94: 1076-1084
21. Cesbron JY, Agut H, Gosselin B, et al. (1994) SCID-Hu mouse as a model for human lung HIV-1 infection. C R Acad Sci III 317: 669-674
22. Chelstrom LM, Gunther R, Simon J, et al (1994) Childhood acute myeloid leukemia in mice with severe combined immunodeficiency. Blood 84: 20-26
23. Chen BP, Galy A, Kyoizumi S, et al. (1994) Engraftment of human hematopoietic precursor cells with secondary transfer potential in SCID-hu mice. Blood 84: 2497-2505
24. Delhem N, Hadida F, Gorochov G, et al. (1997) Anti-HIVgp 160 cytotoxic T cells lines derived from Hu-PBL SCID co-engrafted with human skin after primary immunization using recombinant canary pox. (Submitted for publication)
25. De-Lord C, Clutterbuck R, Powles R, et al. (1994) Growth of primary human acute lymphoblastic and myeloblastic leukemia in SCID mice. Leuk Lymphoma 16: 157-165
26. Dick JE (1996) Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 8: 197-206
27. Dick JE, Sirard C, Pflumio F, et al. (1992) Murine models of normal and neoplastic human haematopoiesis. Cancer Surv 15: 161-181
28. DiGiusto D, Chen S, Combs J, et al. (1994) Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34. Blood 84: 421-432
29. Dorshkind K, Pollack SB, Bosma MJ, et al. (1985) Natural killer (NK) cells are present in mice with severe combined immunodeficiency (SCID). J Immunol 134: 3798-3801
30. Dosch HM, Cochrane DM, Cook VA, et al. (1991) Exogenous but not endogenous EBV induces lymphomas in beige/nude/xid mice carrying human lymphoid xenografts. Int Immunol 3: 731-735
31. Duchosal MA, Eming SA, Mcconahey PJ, et al. (1992) Characterization of hu-PBL-SCID mice with high human immunoglobulin serum levels and graft-versus-host disease. Am J Pathol 141: 1097-1113
32. Durandy A, Emilie D, Peuchmaur M, et al. (1994) Role of IL-6 in promoting growth of human EBV-induced B-cell tumors in severe combined deficient mice. J Immunol 152: 5361-5367
33. Durandy A, Brousse N, Rozenberg F, et al.(1992) Control of human B cell tumor growth in severe combined deficient mice by monoclonal anti-B cell antibodies. J Clin Invest 90: 945-95
34. Franken M, Estabrooks A, Cavacini L, et al. (1996) Epstein-barr virus driven gene therapy for EBV-related lymphomas. Nature Med 2: 1379-1381
35. Fraser CC, Kaneshima H, Hansteen G, et al. (1995) Human allogeneic stem cell maintenance and differentiation in a long-term multilineage SCID-hu graft. Blood 86: 1680-1693
36. Fulop GM, Phillips RA (1990) The SCID mutation in mice causes a general defect in DNA repair. Nature 347: 479-482
37. Goan SR, Fichtner I, Just U, et al. (1995) The severe combined immunodeficient-human peripheral blood stem cell (SCID-huPBSC) mouse: a xenotransplant model for huPBSC-initiated hematopoiesis. Blood 86: 89-100
38. Gunther R, Chelstrom LM, Finnegan D, et al. (1993) In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency. Leukemia 7: 298-309
39. Hoffmannfezer G, Gall C, Zengerle U, et al. (1993) Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice. Blood 81: 3440-3448
40. Hoffmannfezer G, Kranz B, Gall C, et al. (1992) Peritoneal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein-Barr virus-negative donors. Eur J Immunol 22: 3161-3166
41. Huard J, Verreault S, Roy R, et al. (1994) High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice. J Clin Invest 93: 586-599
42. Kamel-Reid S, Dick JE (1988) Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 242: 1706-1709
43. Kaneshima H, Namikawa R, McCune JM (1994) Human hematolymphoid cells in SCID mice. Curr Opin Immunol 6: 327-333
44. Kaufmann R, Mielke V, Reimann J, et al. (1993) Cellular and molecular composition of human skin in long-term xenografts on SCID mice. Exp Dermatol 2: 209-216
45. Kobayashi R, Picchio G, Kirven M, et al. (1992) Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency. Leuk Res 16: 1013-1023
46. Kraft DL, Weissman IL, Waller EK (1993) Differentiation of CD3-4-8- human fetal thymocytes in vivo - characterization of a CD3-4+8- iIntermediate. J Exp Med 178: 265-277
47. Krowka JF, Sarin S, Namikawa R, et al. (1991) Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent J Immunol 146: 3751-3756
48. Kyoizumi S, Baum CM, Kaneshima H, et al (1992) Implantation and maintenance of functional human bone marrow in SCID-hu mice. Blood 79: 1704-1711
49. Kyoizumi S, Murray LJ, Namikawa R (1993) Preclincal analysis of cytokine therapy in the SCID-hu mouse. Blood 81: 1479-1488
50. Lacerda JF (1996) Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted CB-17 SCID/SCID mice (vol. 183, p. 1215, 1996). J Exp Med 184: U15
51. Lapidot T, Faktorowich Y, Lubin I, et al. (1992) Enhancement of T-cell-depleted bone marrow allografts in the absence of graft-versus-host disease is mediated by CD8+CD4- and not by CD8-CD4+ thymocytes. Blood 80: 2406-2411
52. Lapidot T, Pflumio F, Doedens M, et al. (1992) Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 255: 1137-1141
53. Lapidot T, Sirard C, Vormoor J, et al. (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: 645-648
54. Larochelle A, Vormoor J, Hanenberg H, et al. (1996) Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nature Med 12: 1329-1337
55. Lasmezas CI, Cesbron JY, Deslys JP, et al. (1996) Immune system-dependent and -independent replication of the scrapie agent. J Virol 70: 1292-1295
56. Leblond V, Bues C, Chahine H, et al. (1996) Humanisation de la souris SCID par des progéniteurs hématopoiétiques humains. Modèle de thérapie génique et cellulaire (abstract). Hematol Cell Ther 38: 25
57. Levi ADO, Bunge RP (1994) Studies of myelin formation after transplantation of human Schwann cells into the severe combined immunodeficient mouse. Exp Neurol 130: 41-52
58. Louwagie AC, Verwilghen RL (1970) Growth of haemopoietic spleen colonies after grafting of human bone marrow in mice. Nature 225: 383
59. McCune JM, Namikawa R, Kaneshima H, et al. (1988) The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241: 1632-1639
60. Mccune JM (1992)The SCID-hu mouse - a small animal model for the analysis of human hematolymphoid differentiation and function. Bone Marrow Transplant 9: 74-76
61. Miller RD, Ozaki JH, Riblet R (1993) The mouse severe combined immune deficiency (SCID) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda-5. Genomics 16: 740-744
62. Mocarski ES, Bonyhadi M, Salimi S, et al. (1993) Human cytomegalovirus in a SCID-hu mouse - thymic epithelial cells are prominent targets of viral replication. Proc Natl Acad Sci USA 90: 104-108
63. Moffat JF, Stein MD, Kaneshima H, et al. (1995) Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice. J Virol 69: 5236-5242
64. Mosier DE, Gulizia RJ, Baird SM, et al. (1988) Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335: 256-259
65. Mosier DE, Gulizia RJ, Baird SM, et al. (1991) Human immunodeficiency virus infection of human-PBL-SCID mice. Science 251: 791-794
66. Mosier DE, Gulizia RJ, Macisaac PD, et al. (1993) Resistance to human immunodeficiency Virus-1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160. Proc Natl Acad Sci USA 90: 2443-2447
67. Mosier DE, Picchio GR, Kirven MB, et al. (1992) EBV-induced human B-cell lymphomas in hu-PBL-SCID mice. AIDS Res Hum Retroviruses 8: 735-740
68. Mosier DE, Stell KL, Gulizia RJ, et al. (1993) Homozygous SCID/SCID-beige/beige mice have low levels of spontaneous or neonatal T-cell-induced B-cell generation. J Exp Med 177: 191-194
69. Murphy WJ, Conlon KC, Sayers TJ, et al. (1993) Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency. J Immunol 150: 3634-3642
70. Namikawa R, Kaneshima H, Lieberman M, et al. (1988) Infection of the SCID-hu mouse by HIV-1. Science 242: 1684-1686
71. Namikawa R, Weilbaecher KN, Kaneshima H, et al. (1990) Long-term human hematopoiesis in the SCID-hu mouse. J Exp Med 172: 1055-1063
72. Nonoyama S, Smith FO, Bernstein ID, et al. (1993) Strain-dependent leakiness of mice with severe combined immune deficiency. J Immunol 150: 3817-3824
73. Ogura A, Noguchi Y, Yamamoto Y, et al. (1996) Localization of HIV-1 in human thymic implant in SCID-hu mice after intravenous inoculation. Int J Exp Pathol 77: 201-206
74. Peault B, Weissman IL, Baum C, et al. (1991) Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells. J Exp Med 174: 1283-1286
75. Peault B, Tirouvanziam R, Sombardier MN, et al. (1994) Gene transfer to human fetal pulmonary tissue developed in immunodeficient SCID mice. Hum Gene Ther 5: 1131-1137
76. Renner C, Bauer S, Sahin U, et al. (1996) Cure of disseminated xenografted human Hodgkin's tumors by bi-specific monoclonal antibodies and human T cells: the role of human T-cells subsets in a preclinical model. Blood 87: 2930-2937
77. Riddell SR, Greenberg PD (1995) Principles for adoptive T cell therapy of human viral diseases. Annu Rev Immunol 13: 545-586
78. Rowe M, Young LS, Crocker J, et al. (1991) Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man. J Exp Med 173: 147-158
79. Sawyers CL, Gishizky ML, Quan S, et al. (1992) Propagation of human blastic myeloid leukemias in the SCID mouse. Blood 79: 2089-2098
80. Saxon A, Macy E, Denis K, et al. (1991) Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans. J Clin Invest 87: 658-665
81. Segall H, Lubin I, Marcus H, et al. (1996) Generation of primary antigen-specific human cytotoxic T lymphocytes in human/mouse radiation chimera. Blood 88: 721-730
82. Shinkai Y, Rathbun G, Lam KP, et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68: 855-867
83. Sirard C, Lapidot T, Vormoor J, et al. (1996) Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 87: 1539-1548
84. Steinsvik TE, Gaarder PI, Aaberge IS, et al. (1995) Engraftment and humoral immunity in SCID and RAG-2-deficient mice transplanted with human peripheral blood lymphocytes. Scand J Immunol 42: 607-616
85. Sutkowski N, Palkama T, Ciurli C, et al. (1996) An Epstein-Barr virus-associated superantigen. J Exp Med 184: 971-980
86. Tary Lehmann M, Saxon A (1992) Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 175: 503-516
87. Tary Lehmann M, Saxon A, Lehmann PV (1995) The human immune system in hu-PBL-SCID mice. Immunol Today 16: 529-533
88. Torbett BE, Conners K, Shao LE, et al. (1995) High level multilineage engraftment of human hematopoietic cells is maintained in NOD/SCID mice. Blood 86: 436a
89. Uckun FM (1996) Severe combined immunodeficient mouse models of human leukemia. Blood 88: 1135-1146
90. Uckun FM, Downing JR, Chelstrom LM, et al. (1994) Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency. Blood 84: 859-865
91. Uckun FM, Evans WE, Forsyth CJ, et al. (1995) Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases. Science 267: 886-891
92. Uckun FM, Sather H, Reaman G, et al. (1995) Leukemic cell growth in SCID mice as a predictor of relapse in high-risk Blineage acute lymphoblastic leukemia. Blood 85: 873-878
93. Valentine M, Martin A, Unger P, et al. (1994) Preservation of functioning human thyroid organoids in the severe combined immunodeficient mouse .3. Thyrotropin independence of thyroid follicle formation. Endocrinology 134: 1225-1230
94. Van Kuyk R, Torbett BE, Gulizia RJ, et al. (1994) Cloned human CDS+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIW-1 infection by an HLA-unrestricted mechanism. J Immunol 153: 4826-4833
95. Vandekerckhove BA, Krowka JF, McCune JM, et al. (1991) Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol 146: 4173-4179
96. Vandekerckhove BA, Namikawa R, Bacchetta R, et al. (1992) Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. J Exp Med 175: 1033-1043
97. Vandekerckhove BAE, Barcena A, Schols D, et al. (1994) In vivo cytokine expression in the thymus CD3(High) human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells. J Immunol 152: 1738-1743
98. Vandekerckhove BAE, Jones D, Punnonen J, et al. (1993) Human Ig production and isotype switching in severe combined immunodeficient-human mice. J Immunol 151: 128-137
99. Vanhecke D, Leclercq G, Plum J, et al. (1995) Characterization of distinct stages during the differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants. J Immunol 155: 1862-1872
100. Vormoor J, Lapidot T, Larochelle A, et al. (1995) Human hematopoiesis in SCID mice in human. Roncarolo MG, Namikawa R, Peault B. Landes, Austin, Texas, pp. 197-212
101. Vormoor J, Lapidot T, Pflumio F, et al. (1994) Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. Blood 83: 2489-2497
102. Vormoor J, Lapidot T, Pflumio F, et al. (1994) SCID mice as an in vivo model of human cord blood hematopoiesis. Blood Cells 20: 316-322