Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

Human Molecular Genetics

Volumn 18, Issue 14, 2009, Pages 2523-2531

  Takakura, Ayumi ^a   Contrino, Leah ^a   Zhou, Xiangzhi ^b   Bonventre, Joseph V ^a   Sun, Yanping ^b   Humphreys, Benjamin D ^a   Zhou, Jing ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLUTININ; BROMODEOXYCYTIDINE; CRE RECOMBINASE; POLYCYSTIN 1;

ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; DISEASE COURSE; EPITHELIUM CELL; GENE INACTIVATION; KIDNEY INJURY; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; MOUSE; NONHUMAN; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; CYSTS; HUMANS; KIDNEY; MICE; MICE, KNOCKOUT; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; REPERFUSION INJURY; TRPP CATION CHANNELS;

DOLICHOS BIFLORUS;

EID: 67649873481     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp147     Document Type: Article

References (18)

1. Zhou, J. and Pei, Y. (2007) Autosomal dominat polycystic kidney disease. Elsevier, 85-171.
2. Zhou, J. (2009) Polycystins and primary cilia, primers for cell cycle progression. Ann. Rev. Physiol., 71, 83-113.
3. Reeders, S.T. (1992) Multilocus polycystic disease. Nat. Genet., 1, 235-237.
4. Lu, W., Shen, X., Pavlova, A., Lakkis, M., Ward, C.J., Pritchard, L., Harris, P.C., Genest, D.R., Perez-Atayde, A.R. and Zhou, J. (2001) Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum. Mol. Genet., 10, 2385-2396.
5. Lu, W., Peissel, B., Babakhanlou, H., Pavlova, A., Geng, L., Fan, X., Larson, C., Brent, G. and Zhou, J. (1997) Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat. Genet., 17, 179-181.
6. Takakura, A., Contrino, L., Beck, A.W. and Zhou, J. (2008) Pkd1 inactivation induced in adulthood produces focal cystic disease. J. Am. Soc. Nephrol., 19, 2351-2363.
7. Lantinga-van Leeuwen, I.S., Leonhard, W.N., van der Wal, A., Breuning, M.H., de Heer, E. and Peters, D.J. (2007) Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum. Mol. Genet., 16, 3188-3196.
8. Piontek, K., Menezes, L.F., Garcia-Gonzalez, M.A., Huso, D.L. and Germino, G.G. (2007) A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat. Med., 13, 1490-1495.
9. Witzgall, R., Brown, D., Schwarz, C. and Bonventre, J.V. (1994) Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J. Clin. Invest., 93, 2175-2188.
10. Bonventre, J.V. (1988) Mediators of ischemic renal injury. Annu Rev Med, 39, 531-544.
11. Bonventre, J.V. (2003) Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J. Am. Soc. Nephrol., 14 (Suppl 1), S55-S61.
12. Grantham, J.J., Geiser, J.L. and Evan, A.P. (1987) Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney. Int. 31, 1145-1152.
13. Villanueva, S., Cespedes, C. and Vio, C.P. (2006) Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R861-R870.
14. Humphreys, B.D., Valerius, M.T., Kobayashi, A., Mugford, J.W., Soeung, S., Duffield, J.S., McMahon, A.P. and Bonventre, J.V. (2008) Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell, 2, 284-291.
15. Lin, F., Hiesberger, T., Cordes, K., Sinclair, A.M., Goldstein, L.S., Somlo, S. and Igarashi, P. (2003) Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc. Natl Acad. Sci. USA, 100, 5286-5291.
16. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E., Lu, W., Brown, E.M., Quinn, S.J. et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet., 33, 129-137.
17. Patel, V., Li, L., Cobo-Stark, P., Shao, X., Somlo, S., Lin, F. and Igarashi, P. (2008) Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum. Mol. Genet., 17, 1578-1590.
18. Grantham, J.J., Torres, V.E., Chapman, A.B., Guay-Woodford, L.M., Bae, K.T., King, B.F. Jr, Wetzel, L.H., Baumgarten, D.A., Kenney, P.J., Harris, P.C. et al. (2006) Volume progression in polycystic kidney disease. N. Engl. J. Med., 354, 2122-2130.