Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Cell

Volumn 71, Issue 2, 1992, Pages 343-353

  Plump, Andrew S ^a   Smith, Jonathan D ^a   Hayek, Tony ^a   Aalto Setälä, Katriina ^a   Walsh, Annemarie ^a   Verstuyft, Judy G ^b   Rubin, Edward M ^b   Breslow, Jan L ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DIETARY INTAKE; DISEASE PREDISPOSITION; GENE TARGETING; GENETIC RECOMBINATION; HYPERCHOLESTEROLEMIA; LIPOPROTEIN DEFICIENCY; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHOLESTEROL; CORONARY VESSELS; DISEASE MODELS, ANIMAL; HYPERCHOLESTEROLEMIA; LIPOPROTEINS; LIPOPROTEINS, VLDL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PULMONARY ARTERY; STEM CELLS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0026725757     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90362-G     Document Type: Article

References (43)

1. The influence of apolipoprotein polymorphism on the response to dietary fat and cholesterol
2. Transport and storage of vitamin A
3. Production and analysis of chimeric mice
4. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment
5. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. The molecular basis of a familial apo E deficiency: an acceptor splice site mutation in the third intron of the deficient apo E gene
8. Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA
9. Apolipoprotein E polymorphism and atherosclerosis
10. Type III hyperlipoproteinemia associated with apolipoprotein E deficiency
11. Introduction: structure and metabolism of plasma lipoproteins
12. Apolipoprotein E polymorphisms affect atherosclerosis in young males
13. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells
14. Structure and expression of mouse apolipoprotein E gene
15. Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography
16. Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells
17. Aliphatic diether analogs of glyceride-derived lipids. IV. The occurrence of di-O-dihydrophytylglycerol ether containing lipids in extremely halophilic bacteria
18. A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency
19. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
20. Type III hyperlipoproteinemia (dysbetalipoproteinemia): the role of apolipoprotein E in normal and abnormal lipoprotein metabolism
21. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
22. Synthetic low and high fat diets for the study of atherosclerosis in the mouse
23. Variation in susceptibility to atherosclerosis among inbred strains of mice
24. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
25. Quantitative assessment of atherosclerotic lesions in mice
26. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
27. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine
28. Embryo-derived stem cell lines
29. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein A-I
30. Familial apolipoprotein E deficiency
31. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia
32. Accumulation of human apolipoprotein E in the plasma of transgenic mice
33. Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine
34. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
35. Genetic control of human apolipoprotein E polymorphism: comparison of one- and two-dimensional techniques of isoprotein analysis
36. 3
37. The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
38. Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals
39. Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
40. Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification
41. Proposed nomenclature of apo E isoprotein genotypes and phenotypes
42. 2-microglobulin gene produced by homologous recombination in embryonic stem cells