Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 12, 1999, Pages 2981-2992

  Dixon, Joseph L ^a,d   Stoops, J D ^a   Parker, J L ^d   Laughlin, M H ^b,d   Weisman, G A ^a,c   Sturek, M ^d  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c University of Missouri   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Animal model; Atherosclerosis; Cholesterol; Coronary arteries; Endothelium; HDL; LDL; Lipids; Sinclair miniature swine; Triglycerides; Vascular smooth muscle; VLDL

Indexed keywords

ALLOXAN; AMINOTRANSFERASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL; CREATININE; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROSTAGLANDIN F2 ALPHA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; BRACHIAL ARTERY; CAROTID ARTERY; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DYSLIPIDEMIA; HYPERTRIGLYCERIDEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 0033396451     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.12.2981     Document Type: Article

References (68)

1. Ruderman NB, Gupta S, Sussman I. Hyperglycemia, diabetes, and vascular disease: an overview. In: Ruderman N, Williamson J, Brownlee M, eds. Hyperglycemia, Diabetes, and Vascular Disease. New York, NY: Oxford University Press; 1992;3-20.
2. Eastman RC, Cowie CC, Harris MI. Undiagnosed diabetes or impaired glucose tolerance and cardiovascular risk. Diabetes Care. 1997;20: 127-128.
3. Kannel WB, McGee DL. Diabetes and cardiovascular disease: the Framingham study. JAMA. 1979;241:2035-2038.
4. Garber AJ. The touch that kills. Clin Diabetes. 1995;13:57-58.
5. Eschwège E, Balkau B, Fontbonne A. The epidemiology of coronary heart disease in glucose-intolerant and diabetic subjects. J Intern Med. 1994;736(suppl):5-11.
6. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
7. Pyörälä K, Laakso M, Uusitupa M. Diabetes and atherosclerosis: an epidemiologic view. Diabetes Metab Rev. 1987;3:463-524.
8. Semenkovich CF, Heinecke JW. The mystery of diabetes and atherosclerosis: time for a new plot. Diabetes. 1997;46:327-334.
9. Bierman EL. Atherogenesis in diabetes. Arterioscler Thromb. 1992; 12:647-656.
10. Stamler J. Epidemiology, established major risk factors, and the primary prevention of coronary heart disease. In: Parmley WW, Chatterjee K, eds. Cardiology. Philadelphia, Pa: JB Lippincott; 1987:1-41.
11. Steiner G. The dyslipoproteinemias of diabetes. Atherosclerosis. 1994;110(suppl):S27-S33.
12. Reaven GM, Laws A. Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease. Diabetologia. 1994;37:948-952.
13. Sniderman A, Michel C, Racine N. Heart disease in patients with diabetes-mellitus. J Clin Epidemiol. 1992;45:1357-1370.
14. Howard BV, Howard WJ. Dyslipidemia in non-insulin-dependent diabetes mellitus. Endocr Rev. 1994;15:263-274.
15. Caixàs A, Ordónez-Llanos J, De Leiva A, Payes A, Homs R, Perez A. Optimization of glycemic control by insulin therapy decreases the proportion of small dense LDL particles in diabetic patients. Diabetes. 1997;46:1207-1213.
16. Laakso M. Insulin resistance and coronary heart disease. Curr Opin Lipidol. 1996;7:217-226.
17. Pyorala K, Pedersen TR, Kjekshus J, Faergeman O, Olsson AG, Thorgeirsson G, The Scandinavian Simvastatin Survival Study (4S) Group. Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease: a subgroup analysis of the Scandinavian Simvastatin Survival Study (4S). Diabetes Care. 1997;20:614-620.
18. Chobanian AV, Arquilla ER, Clarkson TB, Eder HA, Howard CF Jr, Regan TJ, Williamson JR. Cardiovascular complications. Diabetes. 1982;31:54-64.
19. Barrett-Connor E. Does hyperglycemia really cause coronary heart disease? Diabetes Care. 1997;20:1620-1623.
20. Douglas WR. Of pigs and men and research. Space Life Sci. 1972;3: 226-234.
21. Lee KT. Swine as animal models in cardiovascular research. In: Tumbleson ME, ed. Swine in Biomedical Research. New York, NY: Plenum Publishing Corp; 1986:1481-1496.
22. White FC, Bloor CM. The pig as a model for myocardial ischemia. In: Tumbleson ME, ed. Swine in Biomedical Research. New York, NY: Plenum Publishing Corp; 1986:481-490.
23. Schaper W, Schaper J. Collateral Circulation. New York, NY: Kluwer Academic Publishers; 1993.
24. Jokinen MP, Clarkson TB, Prichard RW. Animal models in atherosclerosis research. Exp Mol Pathol. 1985;42:1-28.
25. Mahley RW, Weisgraber KH, Innerarity T, Brewer HB Jr, Assmann G. Swine lipoproteins and atherosclerosis: changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry. 1975;14:2817-2823.
26. Bell FP, Gerrity RG. Evidence for an altered lipid metabolic state in circulating blood monocytes under conditions of hyperlipemia in swine and its implications in arterial lipid metabolism. Arterioscler Thromb. 1992;12:155-162.
27. Hall JL, Stanley WC, Lopaschuk GD, Wisneski JA, Pizzurro RD, Hamilton CD, McCormack JG. Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work. Am J Physiol. 1996;271:H2320-H2329.
28. Phillips RW, Panepinto LM. Swine as a model for human diabetes. In: Tumbleson ME, ed. Swine in Biomedical Research. New York, NY: Plenum Publishing Corp; 1986:549-560.
29. Sturek M, Liu CY, Dick GM. Voltage-gated calcium channel current in coronary arterial smooth muscle cells from alloxan diabetic pigs. FASEB J. 1996;10:A660. Abstract.
30. Davis SF, Yeung AC, Meredith IT, Charbonneau F, Ganz P, Selwyn AP, Anderson TJ. Early endothelial dysfunction predicts the development of transplant coronary artery disease at 1 year posttransplant. Circulation. 1996;93:457-462.
31. Golenhofen K, Mandrek K, Schaper W, Weinheimer G, Weigand W. Mechanical activity of isolated canine coronary arteries after coronary occlusion. Basic Res Cardiol. 1981;76:480-484.
32. Karasik A, Hattori M. Use of animal models in the study of diabetes. In: Kahn CR, Weir GC, eds. Joslin's Diabetes Mellitus. Philadelphia, Pa: Lea & Febiger; 1994:317-350.
33. Rerup CC. Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev. 1970;22:485-517.
34. Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM. Tests of glycemia in diabetes. Diabetes Care. 1995;18:896-909.
35. Little RR, Goldstein DE. Long-term glucose monitoring with glycated proteins. Lab Med. 1992;23:533-538.
36. Laemmli VK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
37. Rapps JA, Jones AW, Sturek M, Magliola L, Parker JL. Mechanisms of altered contractile responses to vasopressin and endothelin in canine coronary collateral arteries. Circulation. 1997;95:231-239.
38. 2+ and contractile responses of coronary arteries to endothelin. J Appl Physiol. 1995;78:1079-1087.
39. De la Llera-Moya M, Rothblat GH, Glick JM, England JM. Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits. Arterioscler Thromb. 1992;12:1363-1370.
40. Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL. Topographic study of Sudanophilic lesions in cholesterol-fed minipigs by image analysis. Arteriosclerosis. 1985;5:415-426.
41. Holvoet P, Theilmeier G, Shivalkar B, Flameng W, Collen D. LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs. Arterioscler Thromb Vasc Biol. 1998;18:415-422.
42. McAllister RM, Laughlin MH. Short-term exercise training alters responses of porcine femoral and brachial arteries. J Appl Physiol. 1997;82:1438-1444.
43. Strong JP, Wissler RW, Gay S, Miller EJ, Daoud A, Smith LC, Robertson AL, Mergner W, Chandler AB, McManus BM, Cornhill JF, Hixson JE, McMahan A, McGill HC, Virmani R, Jagannathan SN. Natural history and risk factors for early human atherogenesis. Clin Chem. 1995;41:134-138.
44. Taskinen MR, Lahdenperä S, Syvänne M. New insights into lipid metabolism in non-insulin-dependent diabetes mellitus. Ann Med. 1996;28:335-340.
45. Laws A. Free fatty acids, insulin resistance and lipoprotein metabolism. Curr Opin Lipidol. 1996;7:172-177.
46. Thomas WA, Lee KT, Kim DN. Pathogenesis of atherosclerosis in the abdominal aorta and coronary arteries of swine in the first 90 days on a hyperlipidemic diet. In: Tumbleson ME, ed. Swine in Biomedical Research. New York, NY: Plenum Publishing Corp; 1986:1511-1525.
47. Kim DN, Ho HT, Lawrence DA, Schmee J, Thomas WA. Modification of lipoprotein patterns and retardation of atherogenesis by a fish oil supplement to a hyperlipidemic diet for swine. Atherosclerosis. 1987;76:35-43.
48. Chapman MJ, Goldstein S. Comparison of the serum low density lipoprotein and of its apoprotein in the pig, rhesus monkey and baboon with that in man. Atherosclerosis. 1976;25:267-291.
49. Reitman JS, Mahley RW, Fry DL. Yucatan miniature swine as a model for diet-induced atherosclerosis. Atherosclerosis. 1982;43:119-132.
50. Phillips RW, Panepinto LM, Spangler R, Westmoreland N. Yucatan miniature swine as a model for the study of human diabetes-mellitus. Diabetes. 1982;31:30-36.
51. Reitman JS, Mahley RW. Changes induced in the lipoproteins of Yucatan miniature swine by cholesterol feeding. Biochim Biophys Acta. 1979;575:446-457.
52. Mahley RW. Atherogenic hyperlipoproteinemia: the cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol. Med Clin North Am. 1982;66:375-402.
53. Kugiyama K, Doi H, Motoyama T, Soejima H, Misumi K, Kawano H, Nakagawa O, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S, Nakano T, Nakajima K, Yasue H. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation. 1998;97:2519-2526.
54. Marcoux C, Tremblay M, Frenderich A, Jacques H, Krimbou L, Nakajima K, Davignon J, Cohn JS. Plasma remnant-like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Atherosclerosis. 1998;139:161-171.
55. Thollon C, Bidouard JP, Cambarrat C, Delescluse I, Villeneuve N, Vanhoutte PM, Vilaine JP. Alteration of endothelium-dependent hyperpolarizations in porcine coronary arteries with regenerated endothelium. Circ Res. 1999;84:371-377.
56. Tam ES, Ferguson DG, Bielefeld DR, Lorenz JN, Cohen RM, Pun RY. Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat. Cell Calcium. 1997;21:143-150.
57. Barbeau ML, Klemp KF, Guyton JR, Rogers KA. Dietary fish oil: influence on lesion regression in the porcine model of atherosclerosis. Arteriosclerosis. 1997;17:688-694.
58. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 1993;87(suppl V):V-67-V-76.
59. Cohen RA, Zitnay KM, Haudenschild CC, Cunningham LD. Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries. Circ Res. 1988;63:903-910.
60. Pieper GM. Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia. 1999;42:204-213.
61. Gerrity RG, Nadler JL, Natarajan R. Oxidant stress in a new swine model of diabetes-induced accelerated atherosclerosis. Circulation. 1997;96(suppl I):I-175. Abstract.
62. Breslow JL. Mouse models of atherosclerosis. Science. 1996;272: 685-688.
63. Phillips RW, Panepinto LM, Will DH. Genetic selection for diabetogenic traits in Yucatan miniature swine. Diabetes. 1979;28: 1102-1107.
64. Shukla SD, Paul A, Klachko DM. Hypersensitivity of diabetic human platelets to platelet activating factor. Thromb Res. 1992;66:239-246.
65. Gal D, Isner JM. Atherosclerotic Yucatan microswine as a model for novel cardiovascular interventions and imaging. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as Models in Biomedical Research. Ames, Iowa: Iowa State University Press; 1992:118-140.
66. Feletou M, Teisseire B. Vascular pharmacology of the micropig: importance of the endothelium. In: Swindle MM, Moody DC, Phillips LD, eds. Swine as Models in Biomedical Research. Ames, Iowa: Iowa State University Press; 1992:74-95.
67. Thacker PA, Bowland JP. Effects of dietary propionate on serum lipids and lipoproteins in the pig. In: Tumblesoon ME, ed. Swine in Biomedical Research. New York, NY: Plenum Publishing Corp; 1986: 745-754.
68. Lehto M, Ronnemaa T, Haffner SM, Pyorala K, Kallio V, Laakso M. Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM. Diabetes. 1997;46: 1354-1359.