PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

Science

Volumn 272, Issue 5266, 1996, Pages 1339-1342

  Mochizuki, Toshio ^a   Wu, Guanqing ^a   Hayashi, Tomohito ^a   Xenophontos, Stavroulla L ^b   Veldhuisen, Barbera ^c   Saris, Jasper J ^c   Reynolds, David M ^a   Cai, Yiqiang ^a   Gabow, Patricia A ^d   Pierides, Alkis ^e   Kimberling, William J ^f   Breuning, Martijn H ^c   Deltas, C Constantinou ^b   Peters, Dorien J M ^c   Somlo, Stefan ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^c LEIDEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF COLORADO   (United States)

^e NICOSIA GENERAL HOSPITAL   (Cyprus)

^f BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; GENE PRODUCT; MEMBRANE PROTEIN; SODIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FETUS; GENE ISOLATION; HUMAN; HUMAN TISSUE; KIDNEY POLYCYSTIC DISEASE; MOLECULAR CLONING; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 15844385078     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5266.1339     Document Type: Article

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59. We thank R. Kucherlapati, V. Schuster, G. Germino, B. Morrow, and the Kucherlapati laboratory for helpful discussions; G.-J. van Ommen for support; L. Deaven for the chromosome 4-specific cosmid library; D. Lepaslier for YAC clones; J. L. San Millan, S. Gerken, J. Murray, M. Dixon, and J. Weissenbach for STSs; and G. Grills for help with sequencing. Supported by grants from NIH (DK48383, DK02015), the American Heart Association (94015510), the March of Dimes Birth Defects Foundation, the Marion Merrell Dow Award from the Polycystic Kidney Research Foundation, the American Federation for Clinical Research, the Albert Einstein Human Genome Program (S.S.), a Martin Foundation Fellowship (T.M.), the Cyprus Kidney Foundation (C.C.D.), and the Dutch Kidney Foundation (B V. and J.S.).