Autophagy and thyroid carcinogenesis: Genetic and epigenetic links

Endocrine-Related Cancer

Volumn 21, Issue 1, 2014, Pages

  Morani, Federica ^a   Titone, Rossella ^a   Pagano, Loredana ^a   Galetto, Alessandra ^a   Alabiso, Oscar ^a   Aimaretti, Gianluca ^a   Isidoro, Ciro ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Autophagy; Epigenetics; MicroRNA; Oncogenes; Thyroid cancer

Indexed keywords

BECLIN 1; DNA; DNA METHYLTRANSFERASE; DOXORUBICIN; EVEROLIMUS; HISTONE DEACETYLASE; MICRORNA; PACLITAXEL; PROTEIN BCL 2; ROSUVASTATIN; UVOMORULIN; VALPROIC ACID;

AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER DIAGNOSIS; CANCER GROWTH; CARCINOGENESIS; CELL TRANSFORMATION; DNA METHYLATION; EPIGENETICS; HUMAN; IN VITRO STUDY; MACROAUTOPHAGY; ONCOGENE; PHENOTYPE; REVIEW; THYROID CANCER; TUMOR SUPPRESSOR GENE;

AUTOPHAGY; EPIGENETICS; MICRORNA; ONCOGENES; THYROID CANCER;

ANIMALS; AUTOPHAGY; CARCINOGENESIS; EPIGENESIS, GENETIC; GENES, TUMOR SUPPRESSOR; HUMANS; ONCOGENES; SIGNAL TRANSDUCTION; THYROID NEOPLASMS;

EID: 84893615915     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-13-0271     Document Type: Review

References (159)

1. Abraham D, Jackson N, Gundara JS, Zhao J, Gill AJ, Delbridge L, Robinson BG & Sidhu SB 2011 MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets. Clinical Cancer Research 17 4772-4781. (doi:10.1158/1078-0432.CCR-11-0242)
2. Adler JT, Hottinger DG, Kunnimalaiyaan M & Chen HJ 2010 Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride. Journal of Surgical Research 159 640-644. (doi:10.1016/j.jss.2008.08.004)
3. Ain KB 1998 Anaplastic thyroid carcinoma: behavior, biology, and therapeutic approaches. Thyroid 8 715-726. (doi:10.1089/thy.1998.8.715)
4. Akalay I, Janji B, Hasmim M, Noman MZ, André F, De Cremoux P, Bertheau P, Badoual C, Vielh P, Larsen AK et al. 2013 Epithelial-tomesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Research 173 2418-2427. (doi:10.1158/0008-5472. CAN-12-2432)
5. Alers S, Löffler AS, Wesselborg S & Stork B 2012 Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Molecular and Cellular Biology 32 2-11. (doi:10.1128/MCB.06159-11)
6. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD et al. 2010 ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. PNAS 107 4153-4158. (doi:10.1073/pnas. 0913860107)
7. Alvarez-Nuñez F, Bussaglia E, Mauricio D, Ybarra J, Vilar M, Lerma E, de Leiva A, Matias-Guiu X & Thyroid Neoplasia Study Group 2006 PTEN promoter methylation in sporadic thyroid carcinomas. Thyroid 16 17-23. (doi:10.1089/thy.2006.16.17)
8. Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P & Ogier-Denis E 2001 The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. Journal of Biological Chemistry 276 35243-35246. (doi:10.1074/jbc.C100319200)
9. Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP, Fimia GM et al. 2011 Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clinical Cancer Research 17 2216-2226. (doi:10.1158/1078-0432.CCR-10-3003)
10. Begum S, Rosenbaum E, Henrique R, Cohen Y, Sidransky D & Westra WH 2004 BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment. Modern Pathology 17 1359-1363. (doi:10.1038/modpathol.3800198)
11. Braun J & Hüttelmaier S 2011 Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. Thyroid Research 4 S1. (doi:10.1186/1756-6614-4-S1-S1)
12. Braun J, Hoang-Vu C, Dralle H & Huttelmaier S 2010 Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene 29 4237-4244. (doi:10.1038/onc.2010.169)
13. Cahill S, Smyth P, Finn SP, Denning K, Flavin R, O'Regan EM, Li J, Potratz A, Guenther SM, Henfrey R et al. 2006 Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model. Molecular Cancer 5 70. (doi:10.1186/1476-4598-5-70)
14. Cahill S, Smyth P, Denning K, Flavin R, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ & Sheils O 2007 Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model. Molecular Cancer 6 21. (doi:10.1186/1476-4598-6-21)
15. Castino R, Thepparit C, Bellio N, Murphy D & Isidoro C 2008 Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression. Journal of Neuroendocrinology 20 1165-1175. (doi:10.1111/j.1365-2826.2008.01769.x)
16. Castino R, Fiorentino I, Cagnin M, Giovia A & Isidoro C 2011 Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicological Sciences 123 523-541. (doi:10.1093/toxsci/ kfr179)
17. Catalano MG, Fortunati N, Pugliese M, Poli R, Bosco O, Mastrocola R, Aragno M & Boccuzzi G 2006 Valproic acid, a histone deacetylase inhibitor, enhances sensitivity to doxorubicin in anaplastic thyroid cancer cells. Journal of Endocrinology 191 465-472. (doi:10.1677/joe.1.06970)
18. Catalano MG, Poli R, Pugliese M, Fortunati N & Boccuzzi G 2007 Valproic acid enhances tubulin acetylation and apoptotic activity of paclitaxel on anaplastic thyroid cancer cell lines. Endocrine-Related Cancer 14 839-845. (doi:10.1677/ERC-07-0096)
19. Catalano MG, Poli R, Pugliese M, Fortunati N & Boccuzzi G 2010 Emerging molecular therapies of advanced thyroid cancer. Molecular Aspects of Medicine 31 215-226. (doi:10.1016/j.mam.2010.02.006)
20. Catalano MG, Fortunati N & Boccuzzi G 2012a Epigenetics modifications and therapeutic prospects in human thyroid cancer. Frontiers in Endocrinology 3 40. (doi:10.3389/fendo.2012.00040)
21. Catalano MG, Fortunati N, Pugliese M, Marano F, Ortoleva L, Poli R, Asioli S, Bandino A, Palestini N, Grange C et al. 2012b Histone deacetylase inhibition modulates E-cadherin expression and suppresses migration and invasion of anaplastic thyroid cancer cells. Journal of Clinical Endocrinology and Metabolism 97 E1150-E1159. (doi:10.1210/jc.2011-2970)
22. Chau NG & Haddad RI 2013 Vandetanib for the treatment of medullary thyroid cancer. Clinical Cancer Research 19 524-529. (doi:10.1158/1078-0432.CCR- 12-2353)
23. Chen N & Karantza V 2011 Autophagy as a therapeutic target in cancer. Cancer Biology & Therapy 11 157-168. (doi:10.4161/cbt.11.2.14622)
24. Chen Y & Klionsky DJ 2011 The regulation of autophagy - unanswered questions. Journal of Cell Science 124 161-170. (doi:10.1242/jcs.064576)
25. Chun-Zhi Z, Lei H, An-Ling Z, Yan-Chao F, Xiao Y, Guang-Xiu W, Zhi-Fan J, Pei-Yu P, Qing-Yu Z & Chun-Sheng K 2010 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. BMC Cancer 10 367. (doi:10.1186/1471-2407-10-367)
26. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T & Ryan KM 2006 DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126 121-134. (doi:10.1016/j.cell. 2006.05.034)
27. Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C et al. 1997 Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Research 57 4710-4713.
28. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y et al. 2006 Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10 51-64. (doi:10.1016/j.ccr.2006.06.001)
29. De la Chapelle A & Jazdzewski K 2011 MicroRNAs in thyroid cancer. Journal of Clinical Endocrinology and Metabolism 96 3326-3336. (doi:10.1210/jc.2011-1004)
30. Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, Dai Z, Shi GM, Wang XY, Ke AWet al. 2008 Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Research 68 9167-9175. (doi:10.1158/0008-5472.CAN-08-1573)
31. Di Renzo MF, Olivero M, Ferro S, Prat M, Bongarzone I, Pilotti S, Belfiore A, Costantino A, Vigneri R, Pierotti MA et al. 1992 Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene 7 2549-2553.
32. Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R et al. 2011 Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331 456-461. (doi:10.1126/science.1196371)
33. Eng C 2002 Role of PTEN, a lipid phosphatase upstreameffector of protein kinase B, in epithelial thyroid carcinogenesis. Annals of the New York Academy of Sciences 968 213-221. (doi:10.1111/j.1749-6632.2002.tb04337.x)
34. Eskelinen EL 2005 Maturation of autophagic vacuoles in mammalian cells. Autophagy 1 1-10. (doi:10.4161/auto.1.1.1270)
35. Fagin JA & Mitsiades N 2008 Molecularpathology of thyroidcancer: diagnostic and clinical implications. Best Practice & Research. Clinical Endocrinology & Metabolism 22 955-969. (doi:10.1016/j.beem.2008.09.017)
36. Fassnacht M, Kreissl MC, Weismann D & Allolio B 2009 New targets and therapeutic approaches for endocrine malignancies. Pharmacology & Therapeutics 123 117-141. (doi:10.1016/j.pharmthera.2009.03.013)
37. Fornai F, Longone P, Ferrucci M, Lenzi P, Isidoro C, Ruggieri S & Paparelli A 2008 Autophagy and amyotrophic lateral sclerosis: the multiple roles of lithium. Autophagy 4 527-530.
38. Frankel LB & Lund AH 2012 MicroRNA regulation of autophagy. Carcinogenesis 33 2018-2025. (doi:10.1093/carcin/bgs266)
39. Frezzetti D, Menna MD, Zoppoli P, Guerra C, Ferraro A, Bello AM, Luca PD, Calabrese C, Fusco A, Ceccarelli M et al. 2011 Upregulation of miR21 by Ras in vivo and its role in tumor growth. Oncogene 30 275-286. (doi:10.1038/onc.2010. 416)
40. Füllgrabe J, Klionsky DJ & Joseph B 2013 Histone post-translational modifications regulate autophagy flux and outcome. Autophagy 9 1621-1623. (doi:10.4161/auto.25803)
41. Fung C, Lock R, Gao S, Salas E & Debnath J 2008 Induction of autophagy during extracellular matrix detachment promotes cell survival. Molecular Biology of the Cell 19 797-806. (doi:10.1091/mbc.E07-10-1092)
42. Gammoh N, Lam D, Puente C, Ganley I, Marks PA & Jiang X 2012 Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. PNAS 109 6561-6565. (doi:10.1073/pnas.1204429109)
43. Ganley IG, Lam du H, Wang J, Ding X, Chen S & Jiang X 2009 ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. Journal of Biological Chemistry 284 12297-12305. (doi:10.1074/jbc. M900573200)
44. Gao W, Shen Z, Shang L & Wang X 2011 Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death and Differentiation 18 1598-1607. (doi:10.1038/cdd.2011.33)
45. Garcia-Rostan G, Zhao H, Camp RL, Pollan M, Herrero A, Pardo J, Wu R, Carcangiu ML, Costa J & Tallini G 2003 ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer. Journal of Clinical Oncology 21 3226-3235. (doi:10.1200/JCO.2003.10.130)
46. Garcia-Rostan G, Costa AM, Pereira-Castro I, Salvatore G, Hernandez R, Hermsem MJ, Herrero A, Fusco A, Cameselle-Teijeiro J & Santoro M 2005 Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Research 65 10199-10207. (doi:10.1158/0008-5472.CAN-04-4259)
47. Garofalo M, Di Leva G, Romano G, Nuovo G, Suh SS, Ngankeu A, Taccioli C, Pichiorri F, Alder H, Secchiero P et al. 2009 miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell16 498-509. (doi:10.1016/j.ccr.2009.10.014)
48. Ghildiyal M & Zamore PD 2009 Small silencing RNAs: an expanding universe. Nature Reviews. Genetics 10 94-108. (doi:10.1038/nrg2504)
49. Gild ML, Bullock M, Robinson BG & Clifton-Bligh R 2011 Multikinase inhibitors: a new option for the treatment of thyroid cancer. Nature Reviews. Endocrinology 7 617-624. (doi:10.1038/nrendo.2011.141)
50. Gild ML, Landa I, Ryder M, Ghossein RA, Knauf JA & Fagin JA 2013 Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells. Endocrine-Related Cancer 20 659-667. (doi:10.1530/ERC-13-0085)
51. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y & Goodall GJ 2008 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology 10 593-601. (doi:10.1038/ncb1722)
52. Grodski S & Delbridge L 2009 An update on papillary microcarcinoma. Current Opinion in Oncology 21 1-4. (doi:10.1097/CCO.0b013e32831a9a82)
53. Gundara JS, Robinson BG & Sidhu SB 2011 Evolution of the "autophagamiR". Autophagy 7 1553-1554. (doi:10.4161/auto.7.12.17762)
54. Gundara JS, Zhao J, Robinson BG & Sidhu SB 2012 Oncophagy: harnessing regulation of autophagy in cancer therapy. Endocrine-Related Cancer 19 R281-R295. (doi:10.1530/ERC-12-0325)
55. Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V et al. 2011 Activated Ras requiresautophagy tomaintainoxidativemetabolismandtumorigenesis. Genes and Development 25 460-470. (doi:10.1101/gad.2016311)
56. Hamasaki M, Shibutani ST & Yoshimori T 2013 Up-to-date membrane biogenesis in the autophagosome formation. Current Opinion in Cell Biology 25 455-460. (doi:10.1016/j.ceb.2013.03.004)
57. He C & Levine B 2010 The Beclin 1 interactome. Current Opinion in Cell Biology 22 140-149. (doi:10.1016/j.ceb.2010.01.001)
58. He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S et al. 2005 The role of microRNA genes in papillary thyroid carcinoma. PNAS 102 19075-19080. (doi:10.1073/pnas.0509603102)
59. Hoque MO, Rosenbaum E, Westra WH, Xing M, Ladenson P, Zeiger MA, Sidransky D & Umbricht CB 2005 Quantitative assessment of promoter methylation profiles in thyroid neoplasms. Journal of Clinical Endocrinology and Metabolism 90 4011-4018. (doi:10.1210/jc.2005-0313)
60. Huang X, Bai HM, Chen L, Li B & Lu YC 2010 Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors. Journal of Clinical Neuroscience 17 1515-1519. (doi:10.1016/j.jocn.2010.03.051)
61. Huang JJ, Zhu YJ, Lin TY, Jiang WQ, Huang HQ & Li ZM 2011 Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. Human Pathology 42 1459-1466. (doi:10.1016/j.humpath.2010.12.014)
62. Huang Y, Guerrero-Preston R & Ratovitski EA 2012 Phospho- ΔNp63αdependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle 11 1247-1259. (doi:10.4161/cc.11.6.19670)
63. Inoki K, Li Y, Zhu T, Wu J & Guan KL 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biology 4 648-657. (doi:10.1038/ncb839)
64. Iorio MV & Croce CM 2009 MicroRNAs in cancer: small molecules with a huge impact. Journal of Clinical Oncology 27 5848-5856. (doi:10.1200/JCO.2009. 24.0317)
65. Janda E, Isidoro C, Carresi C & Mollace V 2012 Defective autophagy in Parkinson's disease: role of oxidative stress. Molecular Neurobiology 46 639-661. (doi:10.1007/s12035-012-8318-1)
66. Jin SM, Jang HW, Sohn SY, Kim NK, Joung JY, Cho YY, Kim SW & Chung JH 2013 Role of autophagy in the resistance to tumour necrosis factor-related apoptosis-inducing ligand-induced apoptosis in papillary and anaplastic thyroid cancer cells. Endocrine [in press]. (doi:10.1007/s12020-013-9997-8)
67. Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M & Kim DH 2009 ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Molecular Biology of the Cell 20 1992-2003. (doi:10.1091/mbc.E08-12-1249)
68. Kawai A, Uchiyama H, Takano S, Nakamura N & Ohkuma S 2007 Autophagosome-lysosome fusion depends on the pH in acidic compartments in CHO cells. Autophagy 3 154-157.
69. Kim MJ, Woo SJ, Yoon CH, Lee JS, An S, Choi YH, Hwang SG, Yoon G & Lee SJ 2011 Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. Journal of Biological Chemistry 286 12924-12932. (doi:10.1074/jbc.M110.138958)
70. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA et al. 2012 Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8 445-544. (doi:10.4161/auto.19496)
71. Knauf JA, Kuroda H, Basu S & Fagin JA 2003 RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase. Oncogene 22 4406-4412. (doi:10.1038/sj.onc.1206602)
72. Koukourakis MI, Giatromanolaki A, Sivridis E, Pitiakoudis M, Gatter KC & Harris AL 2010 Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. British Journal of Cancer 103 1209-1214. (doi:10.1038/sj.bjc.6605904)
73. Kovaleva V, Mora R, Park YJ, Plass C, Chiramel AI, Bartenschlager R, Döhner H, Stilgenbauer S, Pscherer A, Lichter P et al. 2012 miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. Cancer Research 72 1763-1772. (doi:10.1158/0008- 5472.CAN-11-3671)
74. Kroemer G, Mariño G & Levine B 2010 Autophagy and the integrated stress response. Molecular Cell 22 280-293. (doi:10.1016/j.molcel. 2010.09.023)
75. Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW & Finkel T 2008 A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. PNAS 105 3374-3379. (doi:10.1073/pnas.0712145105)
76. Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J et al. 2010 TP: HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality control autophagy. EMBO Journal 29 969-980. (doi:10.1038/emboj.2009.405)
77. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, Zhu XF & Zhang XS 2009 The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 5 303-306. (doi:10.4161/auto.5.3.7491)
78. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H & Levine B 1999 Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402 672-676. (doi:10.1038/45257)
79. Lim SM, Chang H, Yoon MJ, Hong YK, Kim H, Chung WY, Park CS, Nam KH, Kang SW, Kim MK et al. 2013 A multicenter, phase II trial of everolimus in locally advanced or metastatic thyroid cancer of all histologic subtypes. Annals of Oncology [in press]. (doi:10.1093/annonc/mdt379)
80. Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD Jr & Ruan DT 2009 Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery 146 1208-1214. (doi:10.1016/j.surg.2009.09.019)
81. Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD Jr & Ruan DT 2010 Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Molecular Cancer Research 8 1217-1226. (doi:10.1158/1541-7786. MCR-10-0162)
82. Lin CI, Whang EE, Lorch JH & Ruan DT 2012a Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid. Surgery 152 1142-1149. (doi:10.1016/j.surg.2012.08.016)
83. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K et al. 2012b GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336 477-481. (doi:10.1126/science.1217032)
84. Liu Y, Yang Y, Ye YC, Shi QF, Chai K, Tashiro S, Onodera S & Ikejima T 2012 Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. Journal of Pharmacological Sciences 8 423-432. (doi:10.1254/jphs.11181FP)
85. Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB et al. 2008 The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. Journal of Clinical Investigation 118 3917-3929. (doi:10.1172/JCI35512)
86. Lu CH, Liu YW, Hua SC, Yu HI, Chang YP & Lee YR 2012 Autophagy induction of reversine on human follicular thyroid cancer cells. Biomedicine & Pharmacotherapy 66 642-647. (doi:10.1016/j.biopha.2012.08.001)
87. Maddodi N, Huang W, Havighurst T, Kim K, Longley BJ & Setaluri V 2010 Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF. Journal of Investigative Dermatology 130 1657-1667. (doi:10.1038/jid.2010.26)
88. Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R & Kroemer G 2009 Control of autophagy by oncogenes and tumor suppressor genes. Cell Death and Differentiation 16 87-93. (doi:10.1038/cdd.2008.131)
89. Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA & Kroemer G 2010 Autophagy regulation by p53. Current Opinion in Cell Biology 22 181-185. (doi:10.1016/j.ceb.2009.12.001)
90. Mehrpour M, Esclatine A, Beau I & Codogno P 2010 Overview of macroautophagy regulation in mammalian cells. Cell Research 20 748-762. (doi:10.1038/cr.2010.82)
91. Mineo R, Costantino A, Frasca F, Sciacca L, Russo S, Vigneri R & Belfiore A 2004 Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels. Endocrinology 145 4355-4365. (doi:10.1210/en.2003-1762)
92. Mizushima N & Komatsu M 2011 Autophagy: renovation of cells and tissues. Cell 11 728-741. (doi:10.1016/j.cell.2011.10.026)
93. Mizushima N, Yoshimori T & Ohsumi Y 2011 The role of Atg proteins in autophagosome formation. Annual Review of Cell Biology 27 107-132. (doi:10.1146/annurev-cellbio-092910-154005)
94. Moresi V, Carrer M, Grueter CE, Rifki OF, Shelton JM, Richardson JA, Bassel-Duby R & Olson EN 2012 Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice. PNAS 109 1649-1654. (doi:10.1073/pnas.1121159109)
95. Motoi N, Sakamoto A, Yamochi T, Horiuchi H, Motoi T & Machinami R 2000 Role of ras mutation in the progression of thyroid carcinoma of follicular epithelial origin. Pathology, Research and Practice 196 1-7. (doi:10.1016/S0344-0338(00)80015-1)
96. Nicotra G, Mercalli F, Peracchio C, Castino R, Follo C, Valente G & Isidoro C 2010 Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Modern Pathology 23 937-950. (doi:10.1038/modpathol.2010.80)
97. Nikiforova MN & Nikiforov YE 2009 Molecular diagnostics and predictors in thyroid cancer. Thyroid 19 1351-1361. (doi:10.1089/thy.2009.0240)
98. Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A et al. 2003 BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. Journal of Clinical Endocrinology and Metabolism 88 5399-5404. (doi:10.1210/jc.2003-030838)
99. Noda T, Matsunaga K, Taguchi-Atarashi N & Yoshimori T 2010 Regulation of membrane biogenesis in autophagy via PI3P dynamics. Seminars in Cell & Developmental Biology 21 671-676. (doi:10.1016/j.semcdb.2010.04.002)
100. Noguchi H, Yamashita H, Murakami T, Hirai K, Noguchi Y, Maruta J, Yokoi T & Noguchi S 2009 Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery. Endocrine Journal 56 245-249. (doi:10.1507/endocrj.K08E-016)
101. Ogier-Denis E, Couvineau A, Maoret JJ, Houri JJ, Bauvy C, De Stefanis D, Isidoro C, Laburthe M & Codogno P 1995 A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. Journal of Biological Chemistry 270 13-16. (doi:10.1074/jbc.270.1.13)
102. Ogier-Denis E, Pattingre S, El Benna J & Codogno P 2000 Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. Journal of Biological Chemistry 275 39090-39095. (doi:10.1074/jbc.M006198200)
103. Orenstein SJ & Cuervo AM 2010 Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Seminars in Cell & Developmental Biology 21 719-726. (doi:10.1016/j.semcdb.2010.02.005)
104. Pallante P, Visone R, Ferracin M, Ferraro A, Berlingieri MT, Troncone G, Chiappetta G, Liu CG, Santoro M, Negrini M et al. 2006 MicroRNA deregulation in human thyroid papillary carcinomas. Endocrine-Related Cancer 13 497-508. (doi:10.1677/erc.1.01209)
105. Pallante P, Visone R, Croce CM & Fusco A 2010 Deregulation of microRNA expression in follicular-cell-derived human thyroid carcinomas. Endocrine-Related Cancer 17 91-104. (doi:10.1677/ERC-09-0217)
106. Park SM, Gaur AB, Lengyel E & Peter ME 2008 The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes and Development 22 894-907. (doi:10.1101/gad. 1640608)
107. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD & Levine B 2005 Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122 927-939. (doi:10.1016/j.cell.2005.07.002)
108. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ & Codogno P 2000 Distinct classes of phosphatidylinositol 30-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. Journal of Biological Chemistry 275 992-998. (doi:10.1074/jbc.275.2.992)
109. Pirtoli L, Cevenini G, Tini P, Vannini M, Oliveri G, Marsili S, Mourmouras V, Rubino G & Miracco C 2009 The prognostic role of Beclin 1 protein expression in high-grade gliomas. Autophagy 5 930-936. (doi:10.4161/auto.5.7.9227)
110. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y et al. 2003 Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. Journal of Clinical Investigation 112 1809-1820. (doi:10.1172/JCI200320039)
111. Ramirez R, Hsu D, Patel A, Fenton C, Dinauer C, Tuttle RM & Francis GL 2000 Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma. Clinical Endocrinology 53 635-644. (doi:10.1046/j.1365-2265.2000.01124.x)
112. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S et al. 2010 Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews 90 1383-1435. (doi:10.1152/physrev.00030.2009)
113. Ringel MD, Hayre N, Saito J, Saunier B, Schuppert H, Burch F, Bernet V, Burman KD, Kohn LD & Saji M 2001 Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Research 61 6105-6111.
114. Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S et al. 2011 HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature 471 74-79. (doi:10.1038/nature09803)
115. Rodriguez-Rocha H, Garcia-Garcia A, Panayiotidis MI & Franco R 2011 DNA damage and autophagy. Mutation Research 711 158-166. (doi:10.1016/j.mrfmmm. 2011.03.007)
116. Roman S, Lin R & Sosa JA 2006 Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer 107 2134-2142. (doi:10.1002/cncr.22244)
117. Rubinsztein DC, Shpilka T & Elazar Z 2012 Mechanisms of autophagosome biogenesis. Current Biology 22 R29-R34. (doi:10.1016/j.cub.2011.11.034)
118. Russo D, Damante G, Puxeddu E, Durante C & Filetti S 2011 Epigenetics of thyroid cancer and novel therapeutic targets. Journal of Molecular Endocrinology 46 R73-R81. (doi:10.1530/JME-10-0150)
119. Sahu R, Kaushik S, Clement CC, Cannizzo ES, Scharf B, Follenzi A, Potolicchio I, Nieves E, Cuervo AM & Santambrogio L 2011 Microautophagy of cytosolic proteins by late endosomes. Developmental Cell 20 131-139. (doi:10.1016/j.devcel.2010.12.003)
120. Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S & Sabatini DM 2010 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141 290-303. (doi:10.1016/j.cell.2010.02.024)
121. Santoro M, Melillo RM, Carlomagno F, Vecchio G & Fusco A 2004 Minireview. RET: normal and abnormal functions. Endocrinology 145 5448-5451. (doi:10.1210/en.2004-0922)
122. Schnekenburger M, Grandjenette C, Ghelfi J, Karius T, Foliguet B, Dicato M & Diederich M 2011 Sustained exposure to the DNA demethylating agent, 20-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy. Biochemical Pharmacology 81 364-378. (doi:10.1016/j.bcp.2010.10.013)
123. Schwertheim S, Sheu SY, Worm K, Grabellus F & Schmid KW 2009 Analysis of deregulated miRNAs is helpful to distinguish poorly differentiated thyroid carcinoma from papillary thyroid carcinoma. Hormone and Metabolic Research 41 475-481. (doi:10.1055/s-0029-1215593)
124. Shao Y, Gao Z, Marks PA & Jiang X 2004 Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. PNAS 101 18030-18035. (doi:10.1073/pnas.0408345102)
125. Sheu SY, Grabellus F, Schwertheim S, Worm K, Broecker-Preuss M & Schmid KW 2010 Differential miRNA expression profiles in variants of papillary thyroid carcinoma and encapsulated follicular thyroid tumours. British Journal of Cancer 102 376-382. (doi:10.1038/sj.bjc.6605493)
126. Shinohara M, Chung YJ, Saji M & Singel M 2007 AKT in thyroid tumorigenesis and progression. Endocrinology 148 942-947. (doi:10.1210/en.2006- 0937)
127. Siegel R, Naishadham D & Jemal A 2013 Cancer statistics, 2013. CA: A Cancer Journal for Clinicians 63 11-30. (doi:10.3322/caac.21166)
128. Smallridge RC 2012 Approach to the patient with anaplastic thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 97 2566-2572. (doi:10.1210/jc.2012-1314)
129. Smallridge RC, Marlow LA & Copland JA 2009 Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies. Endocrine-Related Cancer 16 17-44. (doi:10.1677/ERC-08-0154)
130. Smallridge RC, Ain KB, Asa SL, Bible KC, Brierley JD, Burman KD, Kebebew E, Lee NY, Nikiforov YE, Rosenthal MS et al. 2012 American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid 22 1104-1139. (doi:10.1089/thy.2012.0302)
131. Stella GM, Benvenuti S & Comoglio PM 2010 Targeting the MET oncogene in cancer and metastases. Expert Opinion on Investigational Drugs 19 1381-1394. (doi:10.1517/13543784.2010.522988)
132. Takano T, Ito Y, Hirokawa M, Yoshida H & Miyauchi A 2007 BRAF V600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas. British Journal of Cancer 96 1549-1553. (doi:10.1038/sj.bjc.6603764)
133. Tekirdag KA, Korkmaz G, Ozturk DG, Agami R & Gozuacik D 2013 MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy 9 374-385. (doi:10.4161/auto.23117)
134. Tetzlaff MT, Liu A, Xu X, Master SR, Baldwin DA, Tobias JW, Livolsi VA & Baloch ZW 2007 Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues. Endocrine Pathology 18 163-173. (doi:10.1007/s12022-007-0023-7)
135. Thornton K, Kim G, Maher VE, Chattopadhyay S, Tang S, Moon YJ, Song P, Marathe A, Balakrishnan S, Zhu H et al. 2012 Vandetanib for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease: U.S. Food and Drug Administration drug approval summary. Clinical Cancer Research 18 3722-3730. (doi:10.1158/1078-0432.CCR-12-0411)
136. Timp W & Feinberg AP 2013 Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nature Reviews. Cancer 13 497-510. (doi:10.1038/nrc3486)
137. Tooze SA & Yoshimori T 2010 The origin of the autophagosomal
138. True O & Matthias P 2012 Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration. Immunology and Cell Biology 90 78-84. (doi:10.1038/icb.2011.103)
139. Visone R, Russo L, Pallante P, De Martino I, Ferraro A, Leone V, Borbone E, Petrocca F, Alder H, Croce CM et al. 2007 MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle. Endocrine-Related Cancer 14 791-798. (doi:10.1677/ERC-07-0129)
140. Wang Y, Hou P, Yu H, Wang W, Ji M, Zhao S, Yan S, Sun X, Liu D, Shi B et al. 2007 High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors. Journal of Clinical Endocrinology and Metabolism 92 2387-2390. (doi:10.1210/jc.2006-2019)
141. Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J & Levine B 2012 Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 338 956-959. (doi:10.1126/science.1225967)
142. Weber F, Aldred MA, Morrison CD, Plass C, Frilling A, Broelsch CE, Waite KA & Eng C 2005 Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. Journal of Clinical Endocrinology and Metabolism 90 1149-1155. (doi:10.1210/jc.2004-1447)
143. White E & Di Paola RS 2009 The double-edged sword of autophagy modulation in cancer. Clinical Cancer Research 15 5308-5316. (doi:10.1158/1078-0432.CCR-07-5023)
144. Won KY, Kim GY, Lim SJ & Kim YW 2012 Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung. Human Pathology 43 62-68. (doi:10.1016/j.humpath.2011.04.007)
145. Wong PM, Puente C, Ganley IG & Jiang X 2013 The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 9 124-137. (doi:10.4161/auto.23323)
146. Wu G, Mambo E, Guo Z, Hu S, Huang X, Gollin SM, Trink B, Ladenson PW, Sidransky D & Xing M 2005 Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors. Journal of Clinical Endocrinology and Metabolism 90 4688-4693. (doi:10.1210/jc.2004-2281)
147. Wu WK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FK, Yu J & Sung JJ 2012 The autophagic paradox in cancer therapy. Oncogene 31 939-953. (doi:10.1038/onc.2011.295)
148. Wu XY, Chen J, Cao QH, Dong M, Lin Q, Fan XJ, Xia Q, Chen ZH, Liu Q & Wan XB 2013 Beclin 1 activation enhances chemosensitivity and predicts a favorable outcome for primary duodenal adenocarcinoma. Tumour Biology 34 713-722. (doi:10.1007/s13277-012-0599-5)
149. Xing M 2007 BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocrine Reviews 28 742-762. (doi:10.1210/er.2007-0007)
150. Yang Z & Klionsky DJ 2010 Eaten alive: a history of macroautophagy. Nature Cell Biology 12 814-822. (doi:10.1038/ncb0910-814)
151. Yang ZJ, Chee CE, Huang S & Sinicrope FA 2011 The role of autophagy in cancer: therapeutic implications. Molecular Cancer Therapeutics 10 1533-1541. (doi:10.1158/1535-7163.MCT-11-0047)
152. Yang X, Zhong X, Tanyi JL, Shen J, Xu C, Gao P, Zheng TM, DeMichele A & Zhang L 2013 mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochemical and Biophysical Research Communications 431 617-622. (doi:10.1016/j.bbrc.2012.12.083)
153. Yeung SC, She M, Yang H, Pan J, Sun L & Chaplin D 2007 Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model. Journal of Clinical Endocrinology and Metabolism 92 2902-2909. (doi:10.1210/jc.2007-0027)
154. Yi C, Ma M, Ran L, Zheng J, Tong J, Zhu J, Ma C, Sun Y, Zhang S, Feng W et al. 2012 Function and molecular mechanism of acetylation in autophagy regulation. Science 336 474-477. (doi:10.1126/science.1216990)
155. Yue Z, Jin S, Yang C, Levine AJ & Heintz N 2003 Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. PNAS 100 15077-15082. (doi:10.1073/pnas.2436255100)
156. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R & Kimchi A 2009 DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Reports 10 285-292. (doi:10.1038/embor.2008.246)
157. Zeybek ND, Gulcelik NE, Kaymaz FF, Sarisozen C, Vural I, Bodur E, Canpinar H, Usman A & Asan E 2011 Rosuvastatin induces apoptosis in cultured human papillary thyroid cancer cells. Journal of Endocrinology 210 105-115. (doi:10.1530/JOE-10-0411)
158. Zhai H, Fesler A & Ju J 2013 MicroRNA: a third dimension in autophagy. Cell Cycle 12 246-250. (doi:10.4161/cc.23273)
159. Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, Liu CG & Yang JM 2009 Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 5 816-823.