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Volumn 3, Issue MAR, 2012, Pages

Epigenetics modifications and therapeutic prospects in human thyroid cancer

Author keywords

Advanced thyroid cancer; Anaplastic thyroid cancer; Demethylating agents; Epigenetic; Histone deacetylase inhibitors; Target therapy

Indexed keywords


EID: 84864255732     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2012.00040     Document Type: Article
Times cited : (44)

References (91)
  • 2
    • 0030323007 scopus 로고    scopus 로고
    • A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth
    • Anand-Apte, B., Bao, L., Smith, R., Iwata, K., Olsen, B. R., Zetter, B., and Apte, S. S. (1996). A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth. Biochem. Cell Biol. 74, 853-862.
    • (1996) Biochem. Cell Biol. , vol.74 , pp. 853-862
    • Anand-Apte, B.1    Bao, L.2    Smith, R.3    Iwata, K.4    Olsen, B.R.5    Zetter, B.6    Apte, S.S.7
  • 3
    • 67349228774 scopus 로고    scopus 로고
    • Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges
    • Atadja, P. (2009). Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges. Cancer Lett. 280, 233-241.
    • (2009) Cancer Lett , vol.280 , pp. 233-241
    • Atadja, P.1
  • 4
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumori-genesis: epigenetics joins genetics
    • Baylin, S. B., and Herman, J. G. (2000). DNA hypermethylation in tumori-genesis: epigenetics joins genetics. Trends Genet. 16, 168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 5
    • 21744444434 scopus 로고    scopus 로고
    • Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies
    • Blaheta, R. A., Michaelis, M., Driever, P. H., and Cinatl, J. Jr. (2005). Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies. Med. Res. Rev. 25, 383-397.
    • (2005) Med. Res. Rev. , vol.25 , pp. 383-397
    • Blaheta, R.A.1    Michaelis, M.2    Driever, P.H.3    Cinatl Jr, J.4
  • 10
    • 33751505528 scopus 로고    scopus 로고
    • Valproic acid, a histone deacetylase inhibitor, enhances sensitivity to doxorubicin in anaplastic thyroid cancer cells
    • Catalano, M. G., Fortunati, N., Pugliese, M., Poli, R., Bosco, O., Mastro-cola, R., Aragno, M., and Boccuzzi, G. (2006). Valproic acid, a histone deacetylase inhibitor, enhances sensitivity to doxorubicin in anaplastic thyroid cancer cells. J. Endocrinol. 191,465-472.
    • (2006) J. Endocrinol. , vol.191 , pp. 465-472
    • Catalano, M.G.1    Fortunati, N.2    Pugliese, M.3    Poli, R.4    Bosco, O.5    Mastro-cola, R.6    Aragno, M.7    Boccuzzi, G.8
  • 11
    • 35948965312 scopus 로고    scopus 로고
    • Valproic acid enhances tubulin acetylation and apop-totic activity of paclitaxel on anaplastic thyroid cancer cell lines
    • Catalano, M. G., Poli, R., Pugliese, M., Fortunati, N., and Boccuzzi, G. (2007). Valproic acid enhances tubulin acetylation and apop-totic activity of paclitaxel on anaplastic thyroid cancer cell lines. Endocr. Relat. Cancer 14, 839-845.
    • (2007) Endocr. Relat. Cancer , vol.14 , pp. 839-845
    • Catalano, M.G.1    Poli, R.2    Pugliese, M.3    Fortunati, N.4    Boccuzzi, G.5
  • 15
    • 77953995002 scopus 로고    scopus 로고
    • Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers
    • Chi, P., Allis, C. D., and Wang, G. G. (2010). Covalent histone modifications-miswritten, misinterpreted and mis-erased in human cancers. Nat. Rev. Cancer 10, 457-459.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 457-459
    • Chi, P.1    Allis, C.D.2    Wang, G.G.3
  • 16
    • 28044443680 scopus 로고    scopus 로고
    • Alterations of the BRAF gene in thyroid tumors
    • Ciampi, R., and Nikiforov, Y. E. (2005). Alterations of the BRAF gene in thyroid tumors. Endocr. Pathol. 16, 163-172.
    • (2005) Endocr. Pathol. , vol.16 , pp. 163-172
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 17
    • 33846134362 scopus 로고    scopus 로고
    • Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypo-thalamic metastases
    • Copland, J. A., Marlow, L. A., Williams, S. F., Grebe, S. K., Gumz, M. L., Maples, W J., Silverman, V. E., and Smallridge, R. C. (2006). Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypo-thalamic metastases. Thyroid 16, 1293-1302.
    • (2006) Thyroid , vol.16 , pp. 1293-1302
    • Copland, J.A.1    Marlow, L.A.2    Williams, S.F.3    Grebe, S.K.4    Gumz, M.L.5    Maples, W.J.6    Silverman, V.E.7    Smallridge, R.C.8
  • 18
    • 35548987430 scopus 로고    scopus 로고
    • The RASSF1A tumor suppressor
    • Donninger, H., Vos, M. D., and Clark, G. J. (2007). The RASSF1A tumor suppressor. J. Cell Sci. 120, 3163-3172.
    • (2007) J. Cell Sci. , vol.120 , pp. 3163-3172
    • Donninger, H.1    Vos, M.D.2    Clark, G.J.3
  • 21
    • 0032533645 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas
    • Elisei, R., Shiohara, M., Koeffler, H. P, and Fagin, J. A. (1998). Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas. Cancer 83,2185-2193.
    • (1998) Cancer , vol.83 , pp. 2185-2193
    • Elisei, R.1    Shiohara, M.2    Koeffler, H.3    Fagin, P.J.A.4
  • 22
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: targeting chromatin modifications
    • Ellis, L., Atadja, P. W., and Johnstone, R. W. (2009). Epigenetics in cancer: targeting chromatin modifications. Mol. Cancer. Ther. 8,1409-1420.
    • (2009) Mol. Cancer. Ther. , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 23
    • 9444277283 scopus 로고    scopus 로고
    • How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy
    • Fagin, J. A. (2004). How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy.J. Endocrinol. 183, 249-256.
    • (2004) J. Endocrinol. , vol.183 , pp. 249-256
    • Fagin, J.A.1
  • 24
    • 65749120532 scopus 로고    scopus 로고
    • New targets and therapeutic approaches for endocrine malignancies
    • Fassnacht,M.,Kreissl, M. C.,Weismann, D., and Allolio, B. (2009). New targets and therapeutic approaches for endocrine malignancies. Pharmacol. Ther. 123, 117-141.
    • (2009) Pharmacol. Ther. , vol.123 , pp. 117-141
    • Fassnacht, M.1    Kreissl, M.C.2    Weismann, D.3    Allolio, B.4
  • 25
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg, A. P., Ohlsson, R., and Henikoff, S. (2006). The epigenetic progenitor origin of human cancer. Nat Rev. Genet. 7, 21-33.
    • (2006) Nat Rev. Genet. , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 27
    • 1442352159 scopus 로고    scopus 로고
    • Valproic acid induces the expression of the Na+/I- symporter and iodine uptake in poorly differentiated thyroid cancer cells
    • Fortunati, N., Catalano, M. G., Arena, K., Brignardello, E., Piovesan, A., and Boccuzzi, G. (2004). Valproic acid induces the expression of the Na+/I- symporter and iodine uptake in poorly differentiated thyroid cancer cells. J. Clin. Endocrinol. Metab. 89,1006-1009.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 1006-1009
    • Fortunati, N.1    Catalano, M.G.2    Arena, K.3    Brignardello, E.4    Piovesan, A.5    Boccuzzi, G.6
  • 29
    • 1642490813 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
    • Fuino, L., Bali, P., Wittmann, S., Don-apaty, S., Guo, F., Yamaguchi, H., Wang, H. G., Atadja, P., and Bhalla, K. (2003). Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Mol. Cancer Ther. 2, 971-984.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 971-984
    • Fuino, L.1    Bali, P.2    Wittmann, S.3    Don-apaty, S.4    Guo, F.5    Yamaguchi, H.6    Wang, H.G.7    Atadja, P.8    Bhalla, K.9
  • 30
    • 0035108299 scopus 로고    scopus 로고
    • Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis
    • Garcia-Rostan, G., Camp, R. L., Herrero, A., Carcangiu, M. L., Rimm, D. L., and Tallini, G. (2001). Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis. Am. J. Pathol. 158,987-996.
    • (2001) Am. J. Pathol. , vol.158 , pp. 987-996
    • Garcia-Rostan, G.1    Camp, R.L.2    Herrero, A.3    Carcangiu, M.L.4    Rimm, D.L.5    Tallini, G.6
  • 31
    • 65649099308 scopus 로고    scopus 로고
    • Problems and controversies in the histopathology of thyroid carcinomas of follicular cell origin
    • Ghossein, R. (2009). Problems and controversies in the histopathology of thyroid carcinomas of follicular cell origin. Arch. Pathol Lab. Med. 133, 683-691.
    • (2009) Arch. Pathol Lab. Med. , vol.133 , pp. 683-691
    • Ghossein, R.1
  • 33
    • 15144350589 scopus 로고    scopus 로고
    • Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma
    • Graff, J. R., Greenberg, V. E., Herman, J. G., Westra, W. H., Boghaert, E. R., Ain, K. B., Saji, M., Zeiger, M. A., Zimmer, S. G., and Baylin, S. B. (1998). Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res. 58, 2063-2066.
    • (1998) Cancer Res , vol.58 , pp. 2063-2066
    • Graff, J.R.1    Greenberg, V.E.2    Herman, J.G.3    Westra, W.H.4    Boghaert, E.R.5    Ain, K.B.6    Saji, M.7    Zeiger, M.A.8    Zimmer, S.G.9    Baylin, S.B.10
  • 38
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
    • Johnstone, R. W. (2002). Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. DrugDiscov. 1,287-299.
    • (2002) Nat. Rev. DrugDiscov. , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 39
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P. A., and Baylin, S. B. (2007). The epigenomics of cancer. Cell 128, 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 42
    • 67649451962 scopus 로고    scopus 로고
    • Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with dox-orubicin, a synthetic chenodeoxy-cholic acid derivative, or lactacystin
    • Kim, T. H., Yoo, Y. H., Kang, D. Y., Suh, H., Park, M. K., Park, K. J., and Kim, S. H. (2009). Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with dox-orubicin, a synthetic chenodeoxy-cholic acid derivative, or lactacystin. Int.J. Oncol. 34,1353-1362.
    • (2009) Int. J. Oncol. , vol.34 , pp. 1353-1362
    • Kim, T.H.1    Yoo, Y.H.2    Kang, D.Y.3    Suh, H.4    Park, M.K.5    Park, K.J.6    Kim, S.H.7
  • 43
    • 0037974533 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor FR901228 (desipep-tide) restores expression and function of pseudo-null p53
    • Kitazono, M., Bates, S., Fok, P., Fojo, T., and Blagosklonny, M. V. (2002). The histone deacetylase inhibitor FR901228 (desipep-tide) restores expression and function of pseudo-null p53. Cancer Biol. Ther. 1, 665-668.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 665-668
    • Kitazono, M.1    Bates, S.2    Fok, P.3    Fojo, T.4    Blagosklonny, M.V.5
  • 44
    • 0034913856 scopus 로고    scopus 로고
    • Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells
    • Kitazono, M.,Robey, R.,Zhan,Z.,Sarlis, N. J., Skarulis, M. C., Aikou, T., Bates, S., and Fojo, T. (2001). Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells. J. Clin. Endocrinol. Metab. 86, 3430-3435.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3430-3435
    • Kitazono, M.1    Robey, R.2    Zhan, Z.3    Sarlis, N.J.4    Skarulis, M.C.5    Aikou, T.6    Bates, S.7    Fojo, T.8
  • 45
    • 79960381628 scopus 로고    scopus 로고
    • Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling
    • Knauf, J. A., Sartor, M. A., Medve-dovic, M., Lundsmith, E., Ryder, M., Salzano, M., Nikiforov, Y E., Giordano, T. J., Ghossein, R. A., and Fagin, J. A. (2011). Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. Oncogene 30, 3153-3162.
    • (2011) Oncogene , vol.30 , pp. 3153-3162
    • Knauf, J.A.1    Sartor, M.A.2    Medve-dovic, M.3    Lundsmith, E.4    Ryder, M.5    Salzano, M.6    Nikiforov, Y.E.7    Giordano, T.J.8    Ghossein, R.A.9    Fagin, J.A.10
  • 48
    • 0032142918 scopus 로고    scopus 로고
    • Roles of histone acetyltransferases and deacetylases in gene regulation
    • Kuo, M. H., and Allis, C. D. (1998). Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20, 615-626.
    • (1998) Bioessays , vol.20 , pp. 615-626
    • Kuo, M.H.1    Allis, C.D.2
  • 49
    • 52949144622 scopus 로고    scopus 로고
    • DNA methylation: its role in cancer development and therapy
    • Kurkjian, C., Kummar, S., and Murgo, A. J. (2008). DNA methylation: its role in cancer development and therapy. Curr. Probl. Cancer 32, 187-235.
    • (2008) Curr. Probl. Cancer , vol.32 , pp. 187-235
    • Kurkjian, C.1    Kummar, S.2    Murgo, A.J.3
  • 50
    • 0035034282 scopus 로고    scopus 로고
    • Intensity of vascular endothelial growth factor expression is associated with increased risk of recurrence and decreased disease-free survival in papillary thyroid cancer
    • Lennard, C. M., Patel, A., Wilson, J., Reinhardt, B., Tuman, C., Fenton, C., Blair, E., Francis, G. L., and Tuttle, R. M. (2001). Intensity of vascular endothelial growth factor expression is associated with increased risk of recurrence and decreased disease-free survival in papillary thyroid cancer. Surgery 129, 552-558.
    • (2001) Surgery , vol.129 , pp. 552-558
    • Lennard, C.M.1    Patel, A.2    Wilson, J.3    Reinhardt, B.4    Tuman, C.5    Fenton, C.6    Blair, E.7    Francis, G.L.8    Tuttle, R.M.9
  • 51
    • 33749331568 scopus 로고    scopus 로고
    • Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo
    • Luong, Q. T., O'Kelly, J., Braunstein, G. D., Hershman, J. M., and Koeffler, H. P. (2006). Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo. Clin. Cancer Res. 12,5570-5577.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5570-5577
    • Luong, Q.T.1    O'Kelly, J.2    Braunstein, G.D.3    Hershman, J.M.4    Koeffler, H.P.5
  • 53
    • 56349137374 scopus 로고    scopus 로고
    • Retinoic acid receptor beta2 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2'-deoxycytidine treatment
    • Miasaki, F. Y., Vivaldi, A., Ciampi, R., Agate, L., Collecchi, P., Capo-danno, A., Pinchera, A., and Elisei, R. (2008). Retinoic acid receptor beta2 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2'-deoxycytidine treatment. J. Endocrinol. Invest. 31, 724-730.
    • (2008) J. Endocrinol. Invest. , vol.31 , pp. 724-730
    • Miasaki, F.Y.1    Vivaldi, A.2    Ciampi, R.3    Agate, L.4    Collecchi, P.5    Capo-danno, A.6    Pinchera, A.7    Elisei, R.8
  • 58
    • 43049180764 scopus 로고    scopus 로고
    • MicroRNA expression profiling of thyroid tumors: biological significance and 550 diagnostic utility
    • Nikiforova, M. N., Tseng, G. C., Steward, D., Diorio, D., and Nikiforov, Y. E. (2008). MicroRNA expression profiling of thyroid tumors: biological significance and 550 diagnostic utility. J. Clin. Endocrinol. Metab. 93, 1600-1608.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 1600-1608
    • Nikiforova, M.N.1    Tseng, G.C.2    Steward, D.3    Diorio, D.4    Nikiforov, Y.E.5
  • 59
    • 66849128440 scopus 로고    scopus 로고
    • Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery
    • Noguchi, H., Yamashita, H., Murakami, T., Hirai, K., Noguchi, Y., Maruta, J., Yokoi, T., and Noguchi, S. (2009). Successful treatment of anaplastic thyroid carcinoma with a combination of oral valproic acid, chemotherapy, radiation and surgery. Endocr. J. 56, 245-249.
    • (2009) Endocr. J. , vol.56 , pp. 245-249
    • Noguchi, H.1    Yamashita, H.2    Murakami, T.3    Hirai, K.4    Noguchi, Y.5    Maruta, J.6    Yokoi, T.7    Noguchi, S.8
  • 60
    • 79953312648 scopus 로고    scopus 로고
    • BRAF(V600E) and microen-vironment in thyroid cancer: a functional link to drive cancer progression
    • Nucera, C., Lawler, J., and Parangi, S. (2011). BRAF(V600E) and microen-vironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res. 71,2417-2422.
    • (2011) Cancer Res , vol.71 , pp. 2417-2422
    • Nucera, C.1    Lawler, J.2    Parangi, S.3
  • 62
    • 33745199172 scopus 로고    scopus 로고
    • Poorly differentiated and anaplastic thyroid cancer
    • Patel, K. N., and Shaha, A. R. (2006). Poorly differentiated and anaplastic thyroid cancer. Cancer Control 13, 119-128.
    • (2006) Cancer Control , vol.13 , pp. 119-128
    • Patel, K.N.1    Shaha, A.R.2
  • 63
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacety-lase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., and Klein, P. S. (2001). Histone deacety-lase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276, 36734-36741.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 64
    • 1642453460 scopus 로고    scopus 로고
    • Pharmaco-dynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitorPXD101
    • Plumb, J. A., Finn, P. W., Williams, R. J., Bandara, M. J., Romero, M. R., Watkins, C. J., La Thangue, N. B., and Brown, R. (2003). Pharmaco-dynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitorPXD101.Mol. CancerTher. 2,721-728.
    • (2003) Mol. CancerTher. , vol.2 , pp. 721-728
    • Plumb, J.A.1    Finn, P.W.2    Williams, R.J.3    Bandara, M.J.4    Romero, M.R.5    Watkins, C.J.6    La Thangue, N.B.7    Brown, R.8
  • 65
    • 35448983934 scopus 로고    scopus 로고
    • Increase iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC)
    • Provenzano, M. J., Fitzgerald, M. P., Krager, K., and Domann, F. E. (2007). Increase iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC). Otolaryngol. Head Neck Surg. 137, 722-728.
    • (2007) Otolaryngol. Head Neck Surg. , vol.137 , pp. 722-728
    • Provenzano, M.J.1    Fitzgerald, M.P.2    Krager, K.3    Domann, F.E.4
  • 67
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman,S., Lin, R.,andSosa,J. A. (2006). Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer 107,2134-2142.
    • (2006) Cancer , vol.107 , pp. 2134-2142
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 70
    • 49649128638 scopus 로고    scopus 로고
    • Epigenetic drivers and genetic passengers on the road to cancer
    • Sawan, C., Vaissière, T., Murr, R., and Herceg,Z. (2008). Epigenetic drivers and genetic passengers on the road to cancer. Mutat. Res. 642,1-13.
    • (2008) Mutat. Res. , vol.642 , pp. 1-13
    • Sawan, C.1    Vaissière, T.2    Murr, R.3    Herceg, Z.4
  • 71
    • 0036644895 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    • Schagdarsurengin, U., Gimm, O., Hoang-Vu, C., Dralle, H., Pfeifer, G. P., and Dammann, R. (2002). Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma. Cancer Res. 62,3698-3701.
    • (2002) Cancer Res , vol.62 , pp. 3698-3701
    • Schagdarsurengin, U.1    Gimm, O.2    Hoang-Vu, C.3    Dralle, H.4    Pfeifer, G.P.5    Dammann, R.6
  • 74
    • 29144445219 scopus 로고    scopus 로고
    • Valproic acid inhibits growth, induces apop-tosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells
    • Shen, W. T., Wong, T. S., Chung, W. Y., Wong, M. G., Kebebew, E., Duh, Q. Y., and Clark, O. H. (2005). Valproic acid inhibits growth, induces apop-tosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells. Surgery 138, 979-984.
    • (2005) Surgery , vol.138 , pp. 979-984
    • Shen, W.T.1    Wong, T.S.2    Chung, W.Y.3    Wong, M.G.4    Kebebew, E.5    Duh, Q.Y.6    Clark, O.H.7
  • 75
    • 77954762933 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy for differentiated thyroid carcinoma
    • Sherman, S. I. (2010). Cytotoxic chemotherapy for differentiated thyroid carcinoma. Clin. Oncol. (R. Coll. Radiol.) 22, 464-468.
    • (2010) Clin. Oncol. (R. Coll. Radiol. ) , vol.22 , pp. 464-468
    • Sherman, S.I.1
  • 76
    • 79953329570 scopus 로고    scopus 로고
    • Targeted therapies for thyroid tumors
    • Sherman, S. I. (2011). Targeted therapies for thyroid tumors. Mod. Pathol. 24, S44-S52.
    • (2011) Mod. Pathol. , vol.24
    • Sherman, S.I.1
  • 77
    • 65549128212 scopus 로고    scopus 로고
    • Anaplastic thyroid cancer: molecular pathogen-esis and emerging therapies
    • Smallridge, R. C., Marlow, L. A., and Copland, J. A. (2009). Anaplastic thyroid cancer: molecular pathogen-esis and emerging therapies. Endocr. Relat. Cancer 16,17-44.
    • (2009) Endocr. Relat. Cancer , vol.16 , pp. 17-44
    • Smallridge, R.C.1    Marlow, L.A.2    Copland, J.A.3
  • 78
    • 67649993396 scopus 로고    scopus 로고
    • Future of cancer incidence in the United States: burdens upon an aging, changing nation
    • Smith, B. D., Smith, G. L., Hurria, A., Hortobagyi, G. N., and Buchholz, T. A. (2009). Future of cancer incidence in the United States: burdens upon an aging, changing nation. J. Clin. Oncol. 27, 2758-2765.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2758-2765
    • Smith, B.D.1    Smith, G.L.2    Hurria, A.3    Hortobagyi, G.N.4    Buchholz, T.A.5
  • 79
    • 0034051227 scopus 로고    scopus 로고
    • Acetylation of histones and transcription-related factors
    • Sterner, D. E., and Berger, S. L. (2000). Acetylation of histones and transcription-related factors. Micro-biol. Mol. Biol. Rev. 64, 435-459.
    • (2000) Micro-biol. Mol. Biol. Rev. , vol.64 , pp. 435-459
    • Sterner, D.E.1    Berger, S.L.2
  • 81
    • 0033306106 scopus 로고    scopus 로고
    • Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human NaC/IK symporter gene methylation status
    • Venkataraman, G. M., Yatin, M., Marcinek, R., and Ain, K. B. (1999). Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human NaC/IK symporter gene methylation status. J. Clin. Endocrinol. Metab. 84, 2449-2457.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 2449-2457
    • Venkataraman, G.M.1    Yatin, M.2    Marcinek, R.3    Ain, K.B.4
  • 83
    • 0002947085 scopus 로고
    • The epigenotype
    • Waddington, C. H. (1942). The epigenotype. Endeavour 1, 18-20.
    • (1942) Endeavour , vol.1 , pp. 18-20
    • Waddington, C.H.1
  • 84
    • 33646490738 scopus 로고    scopus 로고
    • Derangement of the E-cadherin/catenin complex is involved in transformation of differentiated to anaplastic thyroid carcinoma
    • Wiseman, S. M., Masoudi, H., Niblock, P., Turbin, D., Rajput, A., Hay, J., Filipenko, D., Huntsman, D., and Gilks, B. (2006). Derangement of the E-cadherin/catenin complex is involved in transformation of differentiated to anaplastic thyroid carcinoma. Am. J. Surg. 191,581-587.
    • (2006) Am. J. Surg. , vol.191 , pp. 581-587
    • Wiseman, S.M.1    Masoudi, H.2    Niblock, P.3    Turbin, D.4    Rajput, A.5    Hay, J.6    Filipenko, D.7    Huntsman, D.8    Gilks, B.9
  • 86
    • 37449012509 scopus 로고    scopus 로고
    • Clinical impact of molecular analysis on thyroid cancer management
    • Wreesmann, V B., and Singh, B. (2008). Clinical impact of molecular analysis on thyroid cancer management. Surg. Oncol. Clin. N. Am. 17, 1-35.
    • (2008) Surg. Oncol. Clin. N. Am. , vol.17 , pp. 1-35
    • Wreesmann, V.B.1    Singh, B.2
  • 87
    • 37349131738 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications
    • Xing, M. (2007a). BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr. Rev. 28, 742-762.
    • (2007) Endocr. Rev. , vol.28 , pp. 742-762
    • Xing, M.1
  • 88
    • 33847073463 scopus 로고    scopus 로고
    • Gene methylation in thyroid tumorigenesis
    • Xing, M. (2007b). Gene methylation in thyroid tumorigenesis. Endocrinology 148, 948-953.
    • (2007) Endocrinology , vol.148 , pp. 948-953
    • Xing, M.1
  • 90
    • 0037416151 scopus 로고    scopus 로고
    • HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
    • Zhang, Y., Li, N., Caron, C., Matthias, G., Hess, D., Khochbin, S., and Matthias, P. (2003). HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 22,1168-1179.
    • (2003) EMBO J , vol.22 , pp. 1168-1179
    • Zhang, Y.1    Li, N.2    Caron, C.3    Matthias, G.4    Hess, D.5    Khochbin, S.6    Matthias, P.7


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