메뉴 건너뛰기




Volumn 130, Issue 6, 2010, Pages 1657-1667

Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 77952428054     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.26     Document Type: Article
Times cited : (66)

References (43)
  • 1
    • 33645526114 scopus 로고    scopus 로고
    • Oncogene-induced senescence: Putting the brakes on tumor development
    • Braig M, Schmitt CA (2006) Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res 66:2881-2884
    • (2006) Cancer Res , vol.66 , pp. 2881-2884
    • Braig, M.1    Schmitt, C.A.2
  • 2
    • 0016723594 scopus 로고
    • An endotoxin-induced serum factor that causes necrosis of tumors
    • Carswell EA, Old LJ, Kassel RL et al. (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72:3666-3670
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 3666-3670
    • Carswell, E.A.1    Old, L.J.2    Kassel, R.L.3
  • 3
    • 42949097515 scopus 로고    scopus 로고
    • Malignant transformation initiated by Mll-AF9: Gene dosage and critical target cells
    • Chen W, Kumar AR, Hudson WA et al. (2008) Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell 13:432-440
    • (2008) Cancer Cell , vol.13 , pp. 432-440
    • Chen, W.1    Kumar, A.R.2    Hudson, W.A.3
  • 4
    • 62449266454 scopus 로고    scopus 로고
    • TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): Phospho-Ser2481 is a marker for intact mTOR signaling complex 2
    • Copp J, Manning G, Hunter T (2009) TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res 69:1821-1827
    • (2009) Cancer Res , vol.69 , pp. 1821-1827
    • Copp, J.1    Manning, G.2    Hunter, T.3
  • 5
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti MN, Guan KL (2006) Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25: 6347-6360
    • (2006) Oncogene , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.L.2
  • 6
    • 33845292259 scopus 로고    scopus 로고
    • A negative feedback signaling network underlies oncogene-induced senescence
    • Courtois-Cox S, Williams SMG, Reczek EE et al. (2006) A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10:459-472
    • (2006) Cancer Cell , vol.10 , pp. 459-472
    • Courtois-Cox, S.1    Williams, S.M.G.2    Reczek, E.E.3
  • 7
    • 65649147543 scopus 로고    scopus 로고
    • BrafV600E cooperates with Pten loss to induce metastatic melanoma
    • Dankort D, Curley DP, Cartlidge RA et al. (2009) BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nature Genetics 41:544-552
    • (2009) Nature Genetics , vol.41 , pp. 544-552
    • Dankort, D.1    Curley, D.P.2    Cartlidge, R.A.3
  • 8
    • 33847201454 scopus 로고    scopus 로고
    • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
    • Dankort D, Filenova E, Collado M et al. (2007) A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 21:379-384
    • (2007) Genes Dev , vol.21 , pp. 379-384
    • Dankort, D.1    Filenova, E.2    Collado, M.3
  • 9
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 10
    • 0035670803 scopus 로고    scopus 로고
    • Analysis of N-and K-Ras mutations in the distinctive tumor progression phases of melanoma
    • Demunter A, Stas M, Degreef H et al. (2001) Analysis of N-and K-Ras mutations in the distinctive tumor progression phases of melanoma. J Invest Dermatol 117:1483-1489
    • (2001) J Invest Dermatol , vol.117 , pp. 1483-1489
    • Demunter, A.1    Stas, M.2    Degreef, H.3
  • 11
    • 33750284658 scopus 로고    scopus 로고
    • In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.
    • Dumaz N, Hayward R, Martin J et al. (2006) In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res 66:9483-9491
    • (2006) Cancer Res , vol.66 , pp. 9483-9491
    • Dumaz, N.1    Hayward, R.2    Martin, J.3
  • 12
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis
    • Eisen T, Ahmad T, Flaherty KT et al. (2006) Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 95:581-586
    • (2006) Br J Cancer , vol.95 , pp. 581-586
    • Eisen, T.1    Ahmad, T.2    Flaherty, K.T.3
  • 13
    • 0034971166 scopus 로고    scopus 로고
    • Expression of microtubule-associated protein 2 in benign and malignant melanocytes: Implications for differentiation and progression of cutaneous melanoma
    • Fang D, Hallman J, Sangha N et al. (2001) Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma. Am J Pathol 158:2107-2115
    • (2001) Am J Pathol , vol.158 , pp. 2107-2115
    • Fang, D.1    Hallman, J.2    Sangha, N.3
  • 14
    • 2542628931 scopus 로고    scopus 로고
    • Ras is involved in the negative control of autophagy through the class i PI3-kinase
    • Furuta S, Hidaka E, Ogata A et al. (2004) Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23:3898-3904
    • (2004) Oncogene , vol.23 , pp. 3898-3904
    • Furuta, S.1    Hidaka, E.2    Ogata, A.3
  • 15
    • 53849101410 scopus 로고    scopus 로고
    • Life, death and burial: Multifaceted impact of autophagy
    • Galluzzi L, Morselli E, Vicencio JM et al. (2008) Life, death and burial: multifaceted impact of autophagy. Biochem Soc Trans 036:786-790
    • (2008) Biochem Soc Trans , vol.36 , pp. 786-790
    • Galluzzi, L.1    Morselli, E.2    Vicencio, J.M.3
  • 16
    • 31544442670 scopus 로고    scopus 로고
    • Oncogenic BRAF is required for tumor growth and maintenance in melanoma models
    • Hoeflich KP, Gray DC, Eby MT et al. (2006) Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Cancer Res 66:999-1006
    • (2006) Cancer Res , vol.66 , pp. 999-1006
    • Hoeflich, K.P.1    Gray, D.C.2    Eby, M.T.3
  • 17
    • 48249156591 scopus 로고    scopus 로고
    • Autophagy. An emerging target for cancer therapy
    • Høyer-Hansen M, Jäättelä M (2008) Autophagy. An emerging target for cancer therapy. Autophagy 4:574-580
    • (2008) Autophagy , vol.4 , pp. 574-580
    • Høyer-Hansen, M.1    Jäättelä, M.2
  • 18
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720-5728
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 19
    • 3142757865 scopus 로고    scopus 로고
    • Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
    • Karbowniczek M, Cash T, Cheung M et al. (2004) Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem 279:29930-29937
    • (2004) J Biol Chem , vol.279 , pp. 29930-29937
    • Karbowniczek, M.1    Cash, T.2    Cheung, M.3
  • 20
    • 40649126759 scopus 로고    scopus 로고
    • MTOR is activated in the majority of malignant melanomas
    • Karbowniczek M, Spittle CS, Morrison T et al. (2009) mTOR is activated in the majority of malignant melanomas. J Invest Dermatol 128:980-987
    • (2009) J Invest Dermatol , vol.128 , pp. 980-987
    • Karbowniczek, M.1    Spittle, C.S.2    Morrison, T.3
  • 21
    • 70449123573 scopus 로고    scopus 로고
    • C-Raf inhibits MAPK activation and transformation by B-RafV600E
    • Karreth FA, DeNicola GM, Winter SP et al. (2009) C-Raf inhibits MAPK activation and transformation by B-RafV600E. Mol Cell 36:477-486
    • (2009) Mol Cell , vol.36 , pp. 477-486
    • Karreth, F.A.1    Denicola, G.M.2    Winter, S.P.3
  • 22
    • 18044381192 scopus 로고    scopus 로고
    • Rheb binds and regulates the mTOR kinase
    • Long X, Lin Y, Ortiz-Vega S et al. (2005) Rheb binds and regulates the mTOR kinase. Curr Biol 15:702-713
    • (2005) Curr Biol , vol.15 , pp. 702-713
    • Long, X.1    Lin, Y.2    Ortiz-Vega, S.3
  • 24
    • 57649184088 scopus 로고    scopus 로고
    • Control of autophagy by oncogenes and tumor suppressor genes
    • Maiuri MC, Tasdemir E, Criollo A et al. (2008) Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ 16:87-93
    • (2008) Cell Death Differ , vol.16 , pp. 87-93
    • Maiuri, M.C.1    Tasdemir, E.2    Criollo, A.3
  • 25
    • 23244447037 scopus 로고    scopus 로고
    • BRAFE600-associated senescence-like cell cycle arrest of human naevi
    • Michaloglou C, Vredeveld LC, Soengas WMS et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720-724
    • (2005) Nature , vol.436 , pp. 720-724
    • Michaloglou, C.1    Vredeveld, L.C.2    Soengas, W.M.S.3
  • 26
    • 56849093474 scopus 로고    scopus 로고
    • Distinct thresholds govern Myc's biological output in vivo
    • Murphy DJ, Junttila MR, Pouyet L et al. (2008) Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14:447-457
    • (2008) Cancer Cell , vol.14 , pp. 447-457
    • Murphy, D.J.1    Junttila, M.R.2    Pouyet, L.3
  • 27
    • 0038269032 scopus 로고    scopus 로고
    • Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
    • Pattingre S, Bauvy C, Codogno P (2003) Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 278: 16667-16674
    • (2003) J Biol Chem , vol.278 , pp. 16667-16674
    • Pattingre, S.1    Bauvy, C.2    Codogno, P.3
  • 28
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL et al. (2005) BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15:249-254
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3
  • 29
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot A, Ogier-Denis E, Blommaart EFC et al. (2000) Distinct classes of phosphatidylinositol 3-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 275: 992-998
    • (2000) J Biol Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.C.3
  • 30
    • 33746162101 scopus 로고    scopus 로고
    • Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity
    • Petti C, Molla A, Vegetti C et al. (2006) Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity. Cancer Res 66: 6503-6511
    • (2006) Cancer Res , vol.66 , pp. 6503-6511
    • Petti, C.1    Molla, A.2    Vegetti, C.3
  • 31
    • 41549149451 scopus 로고    scopus 로고
    • Cellular senescence in vivo: A barrier to tumorigenesis
    • Prieur A, Peeper DS (2008) Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 20:150-155
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 150-155
    • Prieur, A.1    Peeper, D.S.2
  • 32
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G et al. (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112:1809-1820
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 33
    • 3042852748 scopus 로고    scopus 로고
    • Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable
    • Romanko MJ, Rothstein RP, Levison SW (2004) Neural stem cells in the subventricular zone are resilient to hypoxia/ischemia whereas progenitors are vulnerable. J Cerebral Blood Flow Metab 24:814-825
    • (2004) J Cerebral Blood Flow Metab , vol.24 , pp. 814-825
    • Romanko, M.J.1    Rothstein, R.P.2    Levison, S.W.3
  • 34
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigen-esis
    • Sarkisian CJ, Keister BA, Stairs DB et al. (2007) Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigen-esis. Nat Cell Biol 9:493-505
    • (2007) Nat Cell Biol , vol.9 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3
  • 35
    • 67649500009 scopus 로고    scopus 로고
    • GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
    • Scott KL, Kabbarah O, Liang M-C et al. (2009) GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 459: 1085-1090
    • (2009) Nature , vol.459 , pp. 1085-1090
    • Scott, K.L.1    Kabbarah, O.2    Liang, M.-C.3
  • 36
    • 33745018419 scopus 로고    scopus 로고
    • Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma
    • Sensi M, Nicolini G, Petti C et al. (2006) Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma. Oncogene 25:3357-3364
    • (2006) Oncogene , vol.25 , pp. 3357-3364
    • Sensi, M.1    Nicolini, G.2    Petti, C.3
  • 37
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3
  • 38
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit DB, Garraway LA, Pratilas CA et al. (2006) BRAF mutation predicts sensitivity to MEK inhibition. Nature 439:358-362
    • (2006) Nature , vol.439 , pp. 358-362
    • Solit, D.B.1    Garraway, L.A.2    Pratilas, C.A.3
  • 39
    • 45849147350 scopus 로고    scopus 로고
    • A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
    • Turcotte S, Chan DA, Sutphin PD et al. (2008) A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 14:90-102
    • (2008) Cancer Cell , vol.14 , pp. 90-102
    • Turcotte, S.1    Chan, D.A.2    Sutphin, P.D.3
  • 40
    • 33644775655 scopus 로고    scopus 로고
    • Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
    • Uribe P, Andrade L, Gonzalez S (2006) Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi. J Invest Dermatol 126:161-166
    • (2006) J Invest Dermatol , vol.126 , pp. 161-166
    • Uribe, P.1    Andrade, L.2    Gonzalez, S.3
  • 41
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapeyee N, Serra RW, Zhu X et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132:363-374
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3
  • 42
    • 58749104425 scopus 로고    scopus 로고
    • Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: A tissue microarray and automated quantitative analysis
    • Warren M, Twohig M, Pier T et al. (2009) Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: a tissue microarray and automated quantitative analysis. Appl Immunohistochem Mol Morphol 17:23-30
    • (2009) Appl Immunohistochem Mol Morphol , vol.17 , pp. 23-30
    • Warren, M.1    Twohig, M.2    Pier, T.3
  • 43
    • 1942506706 scopus 로고    scopus 로고
    • V599EB-RAF is an oncogene in melanocytes
    • Wellbrock C, Ogilvie L, Hedley D et al. (2004) V599EB-RAF is an oncogene in melanocytes. Cancer Res 64:2338-2342
    • (2004) Cancer Res , vol.64 , pp. 2338-2342
    • Wellbrock, C.1    Ogilvie, L.2    Hedley, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.