Inhibition of Growth in Medullary Thyroid Cancer Cells with Histone Deacetylase Inhibitors and Lithium Chloride

Journal of Surgical Research

Volumn 159, Issue 2, 2010, Pages 640-644

  Adler, Joel T ^a   Hottinger, Daniel G ^a   Kunnimalaiyaan, Muthusamy ^a   Chen, Herbert ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

combination therapy; GSK 3 ; histone deacetylase inhibitor; lithium chloride; medullary thyroid cancer; Notch1; suberoyl bis hydroxamic acid; valproic acid

Indexed keywords

CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; LITHIUM CHLORIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH1 RECEPTOR; SUBEROYL BIS HYDROXAMIC ACID; TUMOR MARKER; UNCLASSIFIED DRUG; VALPROIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; THYROID MEDULLARY CARCINOMA; WESTERN BLOTTING;

CELL DIVISION; GLYCOGEN SYNTHASE KINASE 3; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; LITHIUM CHLORIDE; RECEPTOR, NOTCH1; THYROID NEOPLASMS; TUMOR CELLS, CULTURED; UP-REGULATION; VALPROIC ACID;

EID: 77949490246     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.08.004     Document Type: Article

References (21)

1. Chen H., Roberts J.R., Ball D.W., et al. Effective long-term palliation of symptomatic, incurable metastatic medullary thyroid cancer by operative resection. Ann Surg 227 (1998) 887
2. Greenblatt D.Y., and Chen H. Palliation of advanced thyroid malignancies. Surg Oncol 16 (2007) 237
3. Udelsman R., and Chen H. The current management of thyroid cancer. Adv Surg 33 (1999) 1
4. Sippel R.S., Kunnimalaiyaan M., and Chen H. Current management of medullary thyroid cancer. Oncologist 13 (2008) 539
5. Cohen P., and Frame S. The renaissance of GSK3. Nat Rev Mol Cell Biol 2 (2001) 769
6. Cohen P., and Goedert M. GSK3 inhibitors: Development and therapeutic potential. Nature Rev Drug Discovery 3 (2004) 479
7. Kunnimalaiyaan M., Vaccaro A.M., Ndiaye M.A., and Chen H. Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. Mol Cancer Ther 6 (2007) 1151
8. Kunnimalaiyaan M., Vaccaro A.M., Ndiaye M.A., et al. Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 281 (2006) 39819
9. Ball D.W. Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer Cancer 4;204:159
10. Nakakura E.K., Sriuranpong V.R., Kunnimalaiyaan M., et al. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. J Clin Endocrinol Metab 90 (2005) 4350
11. Sriuranpong V., Borges M.W., Ravi R.K., et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 61 (2001) 3200
12. Ning L., Greenblatt D.Y., Kunnimalaiyaan M., et al. Suberoyl bis-hydroxamic acid activates notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist 13 (2008) 98
13. Greenblatt D.Y., Cayo M.A., Adler J.T., et al. Valproic acid activates notch1 signaling and induces apoptosis in medullary thyroid cancer cells. Ann Surg 247 (2008) 1036
14. Ning L., Jaskula-Sztul R., Kunnimalaiyaan M., et al. Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann Surg Onc 15 (2008) 2600
15. Sippel R.S., Carpenter J.E., Kunnimalaiyaan M., et al. Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol 285 (2003) G245
16. Kappes A., Vaccaro A., Kunnimalaiyaan M., et al. Lithium ions: A novel treatment for pheochromocytomas and paragangliomas. Surgery 141 (2007) 161
17. Greenblatt D.Y., Cayo M., Ning L., et al. Suberoyl bishydroxamic acid inhibits cellular proliferation by inducing cell cycle arrest in carcinoid cancer cells. J Gastrointest Surg 11 (2007) 1515
18. Greenblatt D.Y., Vaccaro A.M., Jaskula-Sztul R., et al. Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells. Oncologist 12 (2007) 942
19. Platta C.S., Greenblatt D.Y., Kunnimalaiyaan M., et al. Valproic acid activates the notch1 signaling pathway and inhibits growth in small cell lung cancer cells. J Surg Res 148 (2008) 31
20. Kunnimalaiyaan M., and Chen H. Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 12 (2007) 535
21. Adler J.T., Hottinger D.G., Kunnimalaiyaan M., Chen H., et al. Histone deacetylase inhibitors upregulate notch1 and inhibit growth in pheochromocytoma cells. Surgery 144 (2008) 956