-
1
-
-
0036581222
-
The GDNF family: Signalling, biological functions and therapeutic value
-
(doi:10.1038/nrn812)
-
Airaksinen MS & Saarma M 2002 The GDNF family: signalling, biological functions and therapeutic value. Nature Reviews. Neuroscience 3 383-394. (doi:10.1038/nrn812)
-
(2002)
Nature Reviews. Neuroscience
, vol.3
, pp. 383-394
-
-
Airaksinen, M.S.1
Saarma, M.2
-
2
-
-
34547100555
-
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells
-
(doi:10.1158/0008-5472. CAN-06-4605)
-
Akeno-Stuart N, Croyle M, Knauf JA, Malaguarnera R, Vitagliano D, Santoro M, Stephan C, Grosios K, Wartmann M, Cozens R et al. 2007 The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer Research 67 6956-6964. (doi:10.1158/0008-5472. CAN-06-4605)
-
(2007)
Cancer Research
, vol.67
, pp. 6956-6964
-
-
Akeno-Stuart, N.1
Croyle, M.2
Knauf, J.A.3
Malaguarnera, R.4
Vitagliano, D.5
Santoro, M.6
Stephan, C.7
Grosios, K.8
Wartmann, M.9
Cozens, R.10
-
3
-
-
36849031817
-
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244
-
(doi:10.1210/jc.2007-1184)
-
Ball DW, Jin N, Rosen DM, Dackiw A, Sidransky D, Xing M & Nelkin BD 2007 Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244. Journal of Clinical Endocrinology and Metabolism 92 4712-4718. (doi:10.1210/jc.2007-1184)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, pp. 4712-4718
-
-
Ball, D.W.1
Jin, N.2
Rosen, D.M.3
Dackiw, A.4
Sidransky, D.5
Xing, M.6
Nelkin, B.D.7
-
5
-
-
79251481858
-
Targeting the PI3K/mTOR pathway in murine endocrine cell lines: In vitro and in vivo effects on tumor cell growth
-
(doi:10.1016/j.ajpath.2010.11.023)
-
Couderc C, Poncet G, Villaume K, Blanc M, Gadot N, Walter T, Lepinasse F, Hervieu V, Cordier-Bussat M, Scoazec JY et al. 2011 Targeting the PI3K/mTOR pathway in murine endocrine cell lines: in vitro and in vivo effects on tumor cell growth. American Journal of Pathology 178 336-344. (doi:10.1016/j.ajpath. 2010.11.023)
-
(2011)
American Journal of Pathology
, vol.178
, pp. 336-344
-
-
Couderc, C.1
Poncet, G.2
Villaume, K.3
Blanc, M.4
Gadot, N.5
Walter, T.6
Lepinasse, F.7
Hervieu, V.8
Cordier-Bussat, M.9
Scoazec, J.Y.10
-
6
-
-
84874833803
-
Misidentification of putative medullary thyroid cancer cell lines RO-H85-1 and RO-D81-1
-
(doi:10.1210/jc.2012-4181)
-
Dadon T, Ball D & Nelkin BD 2013 Misidentification of putative medullary thyroid cancer cell lines RO-H85-1 and RO-D81-1. Journal of Clinical Endocrinology and Metabolism 98 954-955. (doi:10.1210/jc.2012-4181)
-
(2013)
Journal of Clinical Endocrinology and Metabolism
, vol.98
, pp. 954-955
-
-
Dadon, T.1
Ball, D.2
Nelkin, B.D.3
-
7
-
-
33747080744
-
RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors
-
(doi:10.1210/er.2006-0017)
-
de Groot JW, Links TP, Plukker JT, Lips CJ & Hofstra RM 2006 RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. Endocrine Reviews 27 535-560. (doi:10.1210/er.2006-0017)
-
(2006)
Endocrine Reviews
, vol.27
, pp. 535-560
-
-
De Groot, J.W.1
Links, T.P.2
Plukker, J.T.3
Lips, C.J.4
Hofstra, R.M.5
-
8
-
-
71849090738
-
The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells
-
(doi:10.1016/j.mce.2009.09.027)
-
Grozinsky-Glasberg S, Rubinfeld H, Nordenberg Y, Gorshtein A, Praiss M, Kendler E, Feinmesser R, Grossman AB & Shimon I 2010 The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells. Molecular and Cellular Endocrinology 315 87-94. (doi:10.1016/j.mce.2009.09.027)
-
(2010)
Molecular and Cellular Endocrinology
, vol.315
, pp. 87-94
-
-
Grozinsky-Glasberg, S.1
Rubinfeld, H.2
Nordenberg, Y.3
Gorshtein, A.4
Praiss, M.5
Kendler, E.6
Feinmesser, R.7
Grossman, A.B.8
Shimon, I.9
-
9
-
-
80054118460
-
Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
-
(doi:10.1158/1078-0432.CCR- 11-0933)
-
Jin N, Jiang T, Rosen DM, Nelkin BD & Ball DW 2011 Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer. Clinical Cancer Research 17 6482-6489. (doi:10.1158/1078-0432.CCR- 11-0933)
-
(2011)
Clinical Cancer Research
, vol.17
, pp. 6482-6489
-
-
Jin, N.1
Jiang, T.2
Rosen, D.M.3
Nelkin, B.D.4
Ball, D.W.5
-
10
-
-
84860380245
-
Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro
-
(doi:10.1530/ERC-11-0155)
-
Koh YW, Shah MH, Agarwal K, McCarty SK, Koo BS, Brendel VJ, Wang C, Porter K, Jarjoura D, Saji M et al. 2012 Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro. Endocrine-Related Cancer 19 29-38. (doi:10.1530/ERC-11-0155)
-
(2012)
Endocrine-Related Cancer
, vol.19
, pp. 29-38
-
-
Koh, Y.W.1
Shah, M.H.2
Agarwal, K.3
McCarty, S.K.4
Koo, B.S.5
Brendel, V.J.6
Wang, C.7
Porter, K.8
Jarjoura, D.9
Saji, M.10
-
11
-
-
33845626635
-
Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
-
(discussion 1014-1005) (doi:10.1016/j.surg.2006.06.040)
-
Kunnimalaiyaan M, Ndiaye M & Chen H 2006 Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 140 1009-1014 (discussion 1014-1005) (doi:10.1016/j.surg.2006.06.040)
-
(2006)
Surgery
, vol.140
, pp. 1009-1014
-
-
Kunnimalaiyaan, M.1
Ndiaye, M.2
Chen, H.3
-
12
-
-
79959936054
-
Activity of XL184 (Cabozantinib) , an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
-
(doi:10.1200/JCO.2010.32.4145)
-
Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, Pfister DG, Cohen EE, Janisch L, Nauling F et al. 2011 Activity of XL184 (Cabozantinib) , an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. Journal of Clinical Oncology 29 2660-2666. (doi:10.1200/JCO. 2010.32.4145)
-
(2011)
Journal of Clinical Oncology
, vol.29
, pp. 2660-2666
-
-
Kurzrock, R.1
Sherman, S.I.2
Ball, D.W.3
Forastiere, A.A.4
Cohen, R.B.5
Mehra, R.6
Pfister, D.G.7
Cohen, E.E.8
Janisch, L.9
Nauling, F.10
-
13
-
-
77952468875
-
Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
-
(doi:10.1200/JCO.2009.25.0068)
-
Lam ET, Ringel MD, Kloos RT, Prior TW, Knopp MV, Liang J, Sammet S, Hall NC, Wakely PE Jr, Vasko VV et al. 2010 Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. Journal of Clinical Oncology 28 2323-2330. (doi:10.1200/JCO.2009.25.0068)
-
(2010)
Journal of Clinical Oncology
, vol.28
, pp. 2323-2330
-
-
Lam, E.T.1
Ringel, M.D.2
Kloos, R.T.3
Prior, T.W.4
Knopp, M.V.5
Liang, J.6
Sammet, S.7
Hall, N.C.8
Wakely Jr., P.E.9
Vasko, V.V.10
-
14
-
-
45149098960
-
BRAFV600E mutation is associated with preferential sensitivity to mitogenactivated protein kinase kinase inhibition in thyroid cancer cell lines
-
(doi:10.1210/jc.2007-2825)
-
Leboeuf R, Baumgartner JE, Benezra M, Malaguarnera R, Solit D, Pratilas CA, Rosen N, Knauf JA & Fagin JA 2008 BRAFV600E mutation is associated with preferential sensitivity to mitogenactivated protein kinase kinase inhibition in thyroid cancer cell lines. Journal of Clinical Endocrinology and Metabolism 93 2194-2201. (doi:10.1210/jc.2007-2825)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, pp. 2194-2201
-
-
Leboeuf, R.1
Baumgartner, J.E.2
Benezra, M.3
Malaguarnera, R.4
Solit, D.5
Pratilas, C.A.6
Rosen, N.7
Knauf, J.A.8
Fagin, J.A.9
-
15
-
-
84255197263
-
Defining the role of TORC1/2 in multiple myeloma
-
(doi:10.1182/blood-2011-03-342394)
-
Maiso P, Liu Y, Morgan B, Azab AK, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A, Ngo H et al. 2011 Defining the role of TORC1/2 in multiple myeloma. Blood 118 6860-6870. (doi:10.1182/blood-2011-03-342394)
-
(2011)
Blood
, vol.118
, pp. 6860-6870
-
-
Maiso, P.1
Liu, Y.2
Morgan, B.3
Azab, A.K.4
Ren, P.5
Martin, M.B.6
Zhang, Y.7
Liu, Y.8
Sacco, A.9
Ngo, H.10
-
16
-
-
74949122343
-
Pancreatic endocrine tumors: Expression profiling evidences a role for AKT-mTOR pathway
-
(doi:10.1200/JCO.2008.21.5988)
-
Missiaglia E, Dalai I, Barbi S, Beghelli S, Falconi M, della Peruta M, Piemonti L, Capurso G, Di Florio A, delle Fave G et al. 2010 Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. Journal of Clinical Oncology 28 245-255. (doi:10.1200/JCO.2008.21.5988)
-
(2010)
Journal of Clinical Oncology
, vol.28
, pp. 245-255
-
-
Missiaglia, E.1
Dalai, I.2
Barbi, S.3
Beghelli, S.4
Falconi, M.5
Della Peruta, M.6
Piemonti, L.7
Capurso, G.8
Di Florio, A.9
Delle Fave, G.10
-
17
-
-
3643067689
-
The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids
-
Powell DJ Jr, Russell J, Nibu K, Li G, Rhee E, Liao M, Goldstein M, Keane WM, Santoro M, Fusco A et al. 1998 The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Research 58 5523-5528.
-
(1998)
Cancer Research
, vol.58
, pp. 5523-5528
-
-
Powell Jr., D.J.1
Russell, J.2
Nibu, K.3
Li, G.4
Rhee, E.5
Liao, M.6
Goldstein, M.7
Keane, W.M.8
Santoro, M.9
Fusco, A.10
-
18
-
-
79960094269
-
Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
-
(doi:10.1210/jc.2010-2655)
-
Rapa I, Saggiorato E, Giachino D, Palestini N, Orlandi F, Papotti M & Volante M 2011 Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 96 2146-2153. (doi:10.1210/jc.2010-2655)
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, pp. 2146-2153
-
-
Rapa, I.1
Saggiorato, E.2
Giachino, D.3
Palestini, N.4
Orlandi, F.5
Papotti, M.6
Volante, M.7
-
19
-
-
77954478933
-
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
-
(doi:10.1210/jc.2009-2461)
-
Robinson BG, Paz-Ares L, Krebs A, Vasselli J & Haddad R 2010 Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. Journal of Clinical Endocrinology and Metabolism 95 2664-2671. (doi:10.1210/jc.2009-2461)
-
(2010)
Journal of Clinical Endocrinology and Metabolism
, vol.95
, pp. 2664-2671
-
-
Robinson, B.G.1
Paz-Ares, L.2
Krebs, A.3
Vasselli, J.4
Haddad, R.5
-
20
-
-
84869425597
-
Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway
-
(doi:10.1016/j.surg.2012.08.031)
-
Samadi AK, Bazzill J, Zhang X, Gallagher R, Zhang H, Gollapudi R, Kindscher K, Timmermann B & Cohen MS 2012 Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway. Surgery 152 1238-1247. (doi:10.1016/j.surg.2012.08.031)
-
(2012)
Surgery
, vol.152
, pp. 1238-1247
-
-
Samadi, A.K.1
Bazzill, J.2
Zhang, X.3
Gallagher, R.4
Zhang, H.5
Gollapudi, R.6
Kindscher, K.7
Timmermann, B.8
Cohen, M.S.9
-
21
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
(doi:10.1126/science.1106148)
-
Sarbassov DD, Guertin DA, Ali SM & Sabatini DM 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 1098-1101. (doi:10.1126/science.1106148)
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
22
-
-
57349103343
-
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification
-
(doi:10.1210/jc.2008-1102)
-
Schweppe RE, Klopper JP, Korch C, Pugazhenthi U, Benezra M, Knauf JA, Fagin JA, Marlow LA, Copland JA, Smallridge RC et al. 2008 Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. Journal of Clinical Endocrinology and Metabolism 93 4331-4341. (doi:10.1210/jc.2008-1102)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, pp. 4331-4341
-
-
Schweppe, R.E.1
Klopper, J.P.2
Korch, C.3
Pugazhenthi, U.4
Benezra, M.5
Knauf, J.A.6
Fagin, J.A.7
Marlow, L.A.8
Copland, J.A.9
Smallridge, R.C.10
-
23
-
-
84655175698
-
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
-
(doi:10.1200/JCO.2011.35.5040)
-
Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, Baudin E, Elisei R, Jarzab B, Vasselli JR et al. 2012 Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. Journal of Clinical Oncology 30 134-141. (doi:10.1200/JCO.2011.35.5040)
-
(2012)
Journal of Clinical Oncology
, vol.30
, pp. 134-141
-
-
Wells Jr., S.A.1
Robinson, B.G.2
Gagel, R.F.3
Dralle, H.4
Fagin, J.A.5
Santoro, M.6
Baudin, E.7
Elisei, R.8
Jarzab, B.9
Vasselli, J.R.10
-
24
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
(doi:10.1056/NEJMoa1009290)
-
Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG et al. 2011 Everolimus for advanced pancreatic neuroendocrine tumors. New England Journal of Medicine 364 514-523. (doi:10.1056/NEJMoa1009290)
-
(2011)
New England Journal of Medicine
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
Bohas, C.L.4
Wolin, E.M.5
Van Cutsem, E.6
Hobday, T.J.7
Okusaka, T.8
Capdevila, J.9
De Vries, E.G.10
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