-
1
-
-
40849094269
-
Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: A 10-year follow-up study
-
Elisei R, Cosci B, Romei C, Bottici V, Renzini G, Molinaro E, et al. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. J Clin Endocrinol Metab 2008;93:682-7.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 682-687
-
-
Elisei, R.1
Cosci, B.2
Romei, C.3
Bottici, V.4
Renzini, G.5
Molinaro, E.6
-
2
-
-
77952468875
-
Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
-
Lam ET, Ringel MD, Kloos RT, Prior TW, Knopp MV, Liang J, et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 2010;28:2323-30.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2323-2330
-
-
Lam, E.T.1
Ringel, M.D.2
Kloos, R.T.3
Prior, T.W.4
Knopp, M.V.5
Liang, J.6
-
3
-
-
78650346128
-
Phase II trial of sunitinib in medullary thyroid cancer
-
de Souza JA, Busaidy N, Zimrin A, Seiwert TY, Vilaflor VM, Poluru KM, et al. Phase II trial of sunitinib in medullary thyroid cancer. J Clin Oncol (Meeting Abstracts) 2010;28:5504.
-
(2010)
J Clin Oncol (Meeting Abstracts)
, vol.28
, pp. 5504
-
-
De Souza, J.A.1
Busaidy, N.2
Zimrin, A.3
Seiwert, T.Y.4
Vilaflor, V.M.5
Poluru, K.M.6
-
4
-
-
68949108390
-
Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
-
Schlumberger MJ, Elisei R, Bastholt L, Wirth LJ, Martins RG, Locati LD, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009;27:3794-801.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3794-3801
-
-
Schlumberger, M.J.1
Elisei, R.2
Bastholt, L.3
Wirth, L.J.4
Martins, R.G.5
Locati, L.D.6
-
5
-
-
50649095801
-
Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
-
Cohen EE, Rosen LS, Vokes EE, Kies MS, Forastiere AA, Worden FP, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 2008;26:4708-13.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4708-4713
-
-
Cohen, E.E.1
Rosen, L.S.2
Vokes, E.E.3
Kies, M.S.4
Forastiere, A.A.5
Worden, F.P.6
-
6
-
-
84866761175
-
A phase II trial of the multitargeted kinase inhibitor lenvatinib (E7080) in advanced medullary thyroid cancer (MTC)
-
Schlumberger M, Jarzab B, Cabanillas ME, Robinson BG, Pacini F, Ball DW, et al. A phase II trial of the multitargeted kinase inhibitor lenvatinib (E7080) in advanced medullary thyroid cancer (MTC). J Clin Oncol (Meeting Abstracts) 2012;30:5591.
-
(2012)
J Clin Oncol (Meeting Abstracts)
, vol.30
, pp. 5591
-
-
Schlumberger, M.1
Jarzab, B.2
Cabanillas, M.E.3
Robinson, B.G.4
Pacini, F.5
Ball, D.W.6
-
7
-
-
79959936054
-
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
-
Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol 2011;29: 2660-6.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2660-2666
-
-
Kurzrock, R.1
Sherman, S.I.2
Ball, D.W.3
Forastiere, A.A.4
Cohen, R.B.5
Mehra, R.6
-
8
-
-
77649214078
-
Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
-
Wells SA Jr, Gosnell JE, Gagel RF, Moley J, Pfister D, Sosa JA, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 2010;28: 767-72.
-
(2010)
J Clin Oncol
, vol.28
, pp. 767-772
-
-
Wells Jr., S.A.1
Gosnell, J.E.2
Gagel, R.F.3
Moley, J.4
Pfister, D.5
Sosa, J.A.6
-
9
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55.
-
(2002)
Cancer Res
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
Kendrew, J.4
Chester, R.5
Jackson, J.A.6
-
10
-
-
0037115405
-
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
-
Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002;62:7284-90.
-
(2002)
Cancer Res
, vol.62
, pp. 7284-7290
-
-
Carlomagno, F.1
Vitagliano, D.2
Guida, T.3
Ciardiello, F.4
Tortora, G.5
Vecchio, G.6
-
11
-
-
23844544081
-
Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
-
Holden SN, Eckhardt SG, Basser R, de Boer R, Rischin D, Green M, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol 2005;16:1391-7.
-
(2005)
Ann Oncol
, vol.16
, pp. 1391-1397
-
-
Holden, S.N.1
Eckhardt, S.G.2
Basser, R.3
De Boer, R.4
Rischin, D.5
Green, M.6
-
12
-
-
33846844387
-
A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
-
Tamura T, Minami H, Yamada Y, Yamamoto N, Shimoyama T, Murakami H, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thorac Oncol 2006;1:1002-9.
-
(2006)
J Thorac Oncol
, vol.1
, pp. 1002-1009
-
-
Tamura, T.1
Minami, H.2
Yamada, Y.3
Yamamoto, N.4
Shimoyama, T.5
Murakami, H.6
-
13
-
-
79956029711
-
Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: An open-label, phase I, rising multiple-dose study
-
Zhang L, Li S, Zhang Y, Zhan J, Zou BY, Smith R, et al. Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: an open-label, phase I, rising multiple-dose study. Clin Ther 2011;33:315-27.
-
(2011)
Clin Ther
, vol.33
, pp. 315-327
-
-
Zhang, L.1
Li, S.2
Zhang, Y.3
Zhan, J.4
Zou, B.Y.5
Smith, R.6
-
14
-
-
77954478933
-
Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
-
Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2010;95:2664-71.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2664-2671
-
-
Robinson, B.G.1
Paz-Ares, L.2
Krebs, A.3
Vasselli, J.4
Haddad, R.5
-
15
-
-
84655175698
-
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind Phase III trial
-
Wells SA Jr, Robinson BG, Gagel RF, Dralle H, Fagin JA, Santoro M, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind Phase III trial. J Clin Oncol 2012;30:134-41.
-
(2012)
J Clin Oncol
, vol.30
, pp. 134-141
-
-
Wells Jr., S.A.1
Robinson, B.G.2
Gagel, R.F.3
Dralle, H.4
Fagin, J.A.5
Santoro, M.6
-
16
-
-
84055207676
-
Vandetanib for the treatment of thyroid cancer
-
Langmuir PB, Yver A. Vandetanib for the treatment of thyroid cancer. Clin Pharmacol Ther 2012;91:71-80.
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 71-80
-
-
Langmuir, P.B.1
Yver, A.2
-
17
-
-
84873398111
-
Medullary thyroid cancer: Advances in treatment and management of common adverse events associated with therapy
-
Haddad RI, Costello R. Medullary thyroid cancer: advances in treatment and management of common adverse events associated with therapy. Commun Oncol 2012;9:188-97.
-
(2012)
Commun Oncol
, vol.9
, pp. 188-197
-
-
Haddad, R.I.1
Costello, R.2
-
18
-
-
84867754481
-
An international, double-blind, randomized, placebo-controlled phase III trial (EXAM) of cabozantinib (XL-184) in medullary thyroid carcinoma patients with documented RECIST progression at baseline
-
Schoffski P, Ellisei R, Miuller S, Brose MS, Shah MH, Licitra L, et al. An international, double-blind, randomized, placebo-controlled phase III trial (EXAM) of cabozantinib (XL-184) in medullary thyroid carcinoma patients with documented RECIST progression at baseline. J Clin Oncol (Meeting Abstracts) 2012;30:5508.
-
(2012)
J Clin Oncol (Meeting Abstracts)
, vol.30
, pp. 5508
-
-
Schoffski, P.1
Ellisei, R.2
Miuller, S.3
Brose, M.S.4
Shah, M.H.5
Licitra, L.6
-
19
-
-
79956290905
-
The effects offour different tyrosine kinase inhibitorson medullary and papillary thyroid cancer cells
-
Verbeek HH, Alves MM, de Groot JW, Osinga J, Plukker JT, Links TP, et al. The effects offour different tyrosine kinase inhibitorson medullary and papillary thyroid cancer cells. J Clin Endocrinol Metab 2011;96: E991-5.
-
(2011)
J Clin Endocrinol Metab
, vol.96
-
-
Verbeek, H.H.1
Alves, M.M.2
De Groot, J.W.3
Osinga, J.4
Plukker, J.T.5
Links, T.P.6
-
20
-
-
4444273158
-
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
-
Carlomagno F, Guida T, Anaganti S, Vecchio G, Fusco A, Ryan AJ, et al. Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors. Oncogene 2004;23:6056-63.
-
(2004)
Oncogene
, vol.23
, pp. 6056-6063
-
-
Carlomagno, F.1
Guida, T.2
Anaganti, S.3
Vecchio, G.4
Fusco, A.5
Ryan, A.J.6
-
21
-
-
33644747449
-
BAY 43-9006 inhibition of oncogenic RET mutants
-
Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, et al. BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 2006;98:326-34.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 326-334
-
-
Carlomagno, F.1
Anaganti, S.2
Guida, T.3
Salvatore, G.4
Troncone, G.5
Wilhelm, S.M.6
-
22
-
-
79955669404
-
High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas
-
Moura MM, Cavaco BM, Pinto AE, Leite V. High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab 2011;96:E863-8.
-
(2011)
J Clin Endocrinol Metab
, vol.96
-
-
Moura, M.M.1
Cavaco, B.M.2
Pinto, A.E.3
Leite, V.4
-
23
-
-
83055198376
-
Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors
-
Morgillo F, Martinelli E, Troiani T, Orditura M, De Vita F, Ciardiello F. Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors. PLoS One 2011;6:e28841.
-
(2011)
PLoS One
, vol.6
-
-
Morgillo, F.1
Martinelli, E.2
Troiani, T.3
Orditura, M.4
De Vita, F.5
Ciardiello, F.6
-
24
-
-
79251531655
-
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells
-
Vitagliano D, De Falco V, Tamburrino A, Coluzzi S, Troncone G, Chiappetta G, et al. The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. Endocr Relat Cancer 2011;18:1-11.
-
(2011)
Endocr Relat Cancer
, vol.18
, pp. 1-11
-
-
Vitagliano, D.1
De Falco, V.2
Tamburrino, A.3
Coluzzi, S.4
Troncone, G.5
Chiappetta, G.6
-
25
-
-
40949130884
-
A phase II study of gefitinib in patients with advanced thyroid cancer
-
Pennell NA, Daniels GH, Haddad RI, Ross DS, Evans T, Wirth LJ, et al. A phase II study of gefitinib in patients with advanced thyroid cancer. Thyroid 2008;18:317-23.
-
(2008)
Thyroid
, vol.18
, pp. 317-323
-
-
Pennell, N.A.1
Daniels, G.H.2
Haddad, R.I.3
Ross, D.S.4
Evans, T.5
Wirth, L.J.6
|