Supraspinal metabotropic glutamate receptors: A target for pain relief and beyond

European Journal of Neuroscience

Volumn 39, Issue 3, 2014, Pages 444-454

  Palazzo, Enza ^a   Marabese, Ida ^a   de Novellis, Vito ^a   Rossi, Francesco ^a   Maione, Sabatino ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Antinociceptive descending pathway; Brain; Chronic pain; Metabotropic glutamate receptors; Psychiatric and neurological disorders

Indexed keywords

METABOTROPIC RECEPTOR; VANILLOID RECEPTOR 1;

ALLOSTERISM; AMYGDALOID NUCLEUS; ANALGESIA; ARTICLE; BRAIN REGION; BRAIN STEM; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM DISEASE; CENTRAL NUCLEUS (AMYGDALA); NEUROMODULATION; NONHUMAN; PAIN; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSTRAL VENTROMEDIAL MEDULLA; SIGNAL TRANSDUCTION; SOLITARY TRACT NUCLEUS; THALAMUS RETICULAR NUCLEUS; THALAMUS VENTRAL NUCLEUS;

ANTINOCICEPTIVE DESCENDING PATHWAY; BRAIN; CHRONIC PAIN; METABOTROPIC GLUTAMATE RECEPTORS; PSYCHIATRIC AND NEUROLOGICAL DISORDERS;

ANIMALS; CENTRAL NERVOUS SYSTEM; EXCITATORY AMINO ACID AGENTS; HUMANS; ORGAN SPECIFICITY; PAIN; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 84893419220     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12398     Document Type: Article

References (135)

1. Aggleton, J.P., Vann, S.D., Oswald, C.J. & Good, M. (2000) Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer. Hippocampus, 10, 466-474.
2. Ansah, O.B., Gonçalves, L., Almeida, A. & Pertovaara, A. (2009) Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals. Exp. Neurol., 216, 66-74.
3. Banik, R.K. & Brennan, T.J. (2004) Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision. Pain, 112, 204-213.
4. Banik, R.K. & Brennan, T.J. (2008) Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation. Pain, 138, 380-391.
5. Behbehani, M.M. (1995) Functional characteristics of the midbrain periaqueductal gray. Prog. Neurobiol., 46, 575-605.
6. Behbehani, M.M. & Fields, H.L. (1979) Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res., 170, 85-93.
7. Bernard, J.F. & Bandler, R. (1998) Parallel circuits for emotional coping behaviour: new pieces in the puzzle. J. Comp. Neurol., 401, 429-436.
8. Berrino, L., Oliva, P., Rossi, F., Palazzo, E., Nobili, B. & Maione, S. (2001) Interaction between metabotropic and NMDA glutamate receptors in the periaqueductal grey pain modulatory system. N.-S. Arch. Pharmacol., 364, 437-443.
9. Bhave, G., Karim, F., Carlton, S.M. & Gereau, R.W. (2001) Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat. Neurosci., 4, 417-423.
10. Bleakman, D. & Lodge, D. (1998) Neuropharmacology of AMPA and kainate receptors. Neuropharmacology, 37, 1187-1204.
11. Byrnes, K.R., Stoica, B., Loane, D.J., Riccio, A., Davis, M.I. & Faden, A.I. (2009) Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia, 57, 550-560.
12. Carlton, S.M., Hargett, G.L. & Coggeshall, R.E. (1995) Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci. Lett., 197, 25-28.
13. Carlton, S.M., Du, J. & Zhou, S. (2009a) Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function. Brain Res., 1248, 86-95.
14. Carlton, S.M., Du, J., Tan, H.Y., Nesic, O., Hargett, G.L., Bopp, A.C., Yamani, A., Lin, Q., Willis, W.D. & Hulsebosch, C.E. (2009b) Peripheral and central sensitization in remote spinal cord regions contribute to central neuropathic pain after spinal cord injury. Pain, 147, 265-276.
15. Carlton, S.M., Zhou, S., Govea, R. & Du, J. (2011) Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors. J. Neurosci., 31, 12727-12737.
16. Cartmell, J. & Schoepp, D.D. (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J. Neurochem., 75, 889-907.
17. Catania, M.V., De Socarraz, H., Penney, J.B. & Young, A.B. (1994) Metabotropic glutamate receptor heterogeneity in rat brain. Mol. Pharmacol., 45, 626-636.
18. Caterina, M.J. (2007) Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am. J. Physiol-Reg. I., 292, 64-76.
19. Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I. & Julius, D. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 288, 306-313.
20. Chen, S.R. & Pan, H.L. (2005) Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured rats. J. Pharmacol. Exp. Ther., 312, 120-126.
21. Chiechio, S., Zammataro, M., Morales, M.E., Busceti, C.L., Drago, F., Gereau, R.W. IV., Copani, A. & Nicoletti, F. (2009) Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Mol. Pharmacol., 75, 1014-1020.
22. Conn, P.J. & Pin, J.P. (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol., 37, 205-237.
23. Crock, L.W., Stemler, K.M., Song, D.G., Abbosh, P., Vogt, S.K., Qiu, C.S., Lai, H.H., Mysorekar, I.U. & Gereau, R.W. (2012) Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol. Pain, 26, 8-20.
24. D'Antoni, S., Berretta, A., Bonaccorso, C.M., Bruno, V., Aronica, E., Nicoletti, F. & Catania, M.V. (2008) Metabotropic glutamate receptors in glial cells. Neurochem. Res., 33, 2436-2443.
25. De Petrocellis, L., Chu, C.J., Moriello, A.S., Kellner, J.C., Walker, J.M. & Di Marzo, V. (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Brit. J. Pharmacol., 143, 251-256.
26. Doherty, J. & Dingledine, R. (2003) Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system. Curr. Opin. Pharmacol., 3, 46-53.
27. Dolan, S. & Nolan, A.M. (2000) Behavioural evidence supporting a differential role for group I and II metabotropic glutamate receptors in spinal nociceptive transmission. Neuropharmacology, 39, 1132-1138.
28. Dolan, S., Gunn, M.D., Biddlestone, L. & Nolan, A.M. (2009) The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. Behav. Pharmacol., 20, 596-604.
29. Dolan, S., Gunn, M.D., Crossan, C. & Nolan, A.M. (2011) Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. Behav. Pharmacol., 22, 582-588.
30. Drew, G.M. & Vaughan, C.W. (2004) Multiple metabotropic glutamate receptor subtypes modulate GABAergic neurotransmission in rat periaqueductal grey neurons in vitro. Neuropharmacology, 46, 927-934.
31. Du, J., Zhou, S., Coggeshall, R.E. & Carlton, S.M. (2003) N-methyl-D-aspartate induced excitation and sensitization of normal and inflamed nociceptors. Neuroscience, 118, 547-562.
32. Du, J., Zhou, S. & Carlton, S.M. (2006) Kainate-induced excitation and sensitization of nociceptors in normal and inflamed rat glabrous skin. Neuroscience, 137, 999-1013.
33. Ferraguti, F. & Shigemoto, R. (2006) Metabotropic glutamate receptors. Cell Tissue Res., 326, 483-504.
34. Fields, H.L. (2004) State-dependent opioid control of pain. Nat. Rev. Neurosci., 5, 565-575.
35. Fields, H.L. & Basbaum, A.I. (1999) Central nervous system mechanisms of pain modulation. In Wall, P.D. & Melzack, R. (Eds), Textbook of Pain. Churchill Livingstone, New York, pp. 243-257.
36. Fields, H.L., Bry, J., Hentall, I. & Zorman, G. (1983) The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J. Neurosci., 3, 2545-2552.
37. Fundytus, M.E., Osborne, M.G., Henry, J.L., Coderre, T.J. & Dray, A. (2002) Antisense oligonucleotide knockdown of mGluR1 alleviates hyperalgesia and allodynia associated with chronic inflammation. Pharmacol. Biochem. Be., 73, 401-410.
38. Garcia, R., Vouimba, R.M., Baudry, M. & Thompson, R.F. (1999) The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature, 402, 294-296.
39. Gerber, G., Zhong, J., Youn, D. & Randic, M. (2000) Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience, 100, 393-406.
40. Goudet, C., Chapuy, E., Alloui, A., Acher, F., Pin, J.P. & Eschalier, A. (2008) Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain, 137, 112-124.
41. Guo, W., Wei, F., Zou, S., Robbins, M.T., Sugiyo, S., Ikeda, T., Tu, J.C., Worley, P.F., Dubner, R. & Ren, K. (2004) Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. J. Neurosci., 24, 9161-9173.
42. Han, J.S. & Neugebauer, V. (2005) mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain. Pain, 113, 211-222.
43. Han, J.S., Bird, G.C. & Neugebauer, V. (2004) Enhanced group III mGluR-mediated inhibition of pain-related synaptic plasticity in the amygdala. Neuropharmacology, 46, 918-926.
44. Heinricher, M.M. & Tortorici, V. (1994) Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation. Neuroscience, 63, 533-546.
45. Heinricher, M.M., Barbaro, N.M. & Fields, H.L. (1989) Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of on- and off-cells is related to nociceptive responsiveness. Somatosens. Mot. Res., 6, 427-439.
46. Helton, D.R., Tizzano, J.P., Monn, J.A., Schoepp, D.D. & Kallman, M.J. (1998) Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J. Pharmacol. Exp. Ther., 284, 651-660.
47. Hu, H.J., Bhave, G. & Gereau, R.W. (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. J. Neurosci., 22, 7444-7452.
48. Hu, H.J., Alter, B.J., Carrasquillo, Y., Qiu, C.S. & Gereau, R.W. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J. Neurosci., 27, 13181-13191.
49. Jang, J.H., Kim, D.W., Sang Nam, T., Se Paik, K. & Leem, J.W. (2004) Peripheral glutamate receptors contribute to mechanical hyperalgesia in a neuropathic pain model of the rat. Neuroscience, 128, 169-176.
50. Ji, G. & Neugebauer, V. (2010) Reactive oxygen species are involved in group I mGluR-mediated facilitation of nociceptive processing in amygdala neurons. J. Neurophysiol., 104, 218-229.
51. Ji, G. & Neugebauer, V. (2011) Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J. Neurophysiol., 106, 2642-2652.
52. Ji, G., Zhou, S., Kochukov, M.Y., Westlund, K.N. & Carlton, S.M. (2007) Plasticity in intact A delta- and C-fibers contributes to cold hypersensitivity in neuropathic rats. Neuroscience, 150, 182-193.
53. Ji, G., Zhou, S. & Carlton, S.M. (2008) Intact A delta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience, 154, 1054-1066.
54. Ji, G., Sun, H., Fu, Y., Li, Z., Pais-Vieira, M., Galhardo, V. & Neugebauer, V. (2010) Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J. Neurosci., 30, 5451-5464.
55. Jin, Y.H., Yamaki, F., Takemura, M., Koike, Y., Furuyama, A. & Yonehara, N. (2009) Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers. J. Pharmacol. Sci., 109, 233-241.
56. Jones, C.K., Eberle, E.L., Peters, S.C., Monn, J.A. & Shannon, H.E. (2005) Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Neuropharmacology, 49, 1206-1218.
57. Karim, F., Wang, C.C. & Gereau, R.W. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci., 21, 3771-3779.
58. Kim, H., Cui, L., Kim, J. & Kim, S.J. (2009) Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn. Neuroscience, 160, 508-516.
59. Kolber, B.J., Montana, M.C., Carrasquillo, Y., Xu, J., Heinemann, S.F., Muglia, L.J. & Gereau, R.W. (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. J. Neurosci., 30, 8203-8213.
60. Latremoliere, A. & Woolf, C.J. (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J. Pain, 10, 895-926.
61. Leyva, J., Maione, S., Pallotta, M., Berrino, L. & Rossi, F. (1995) Metabotropic and ionotropic glutamate receptors mediate opposite effects on periaqueductal gray matter. Eur. J. Pharmacol., 285, 123-126.
62. Li, W. & Neugebauer, V. (2004) Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. J. Neurophysiol., 91, 13-24.
63. Li, W. & Neugebauer, V. (2006) Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain. J. Neurophysiol., 96, 1803-1815.
64. Li, Z., Ji, G. & Neugebauer, V. (2011) Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. J. Neurosci., 31, 1114-1127.
65. Liu, X.H., Han, M., Zhu, J.X., Sun, N., Tang, J.S., Huo, F.Q., Li, J., Xu, F.Y. & Du, J.Q. (2012) Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius. Neuroscience, 220, 322-329.
66. Luongo, L., de Novellis, V., Gatta, L., Palazzo, E., Vita, D., Guida, F., Giordano, C., Siniscalco, D., Marabese, I., De Chiaro, M., Boccella, S., Rossi, F. & Maione, S. (2013) Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology, 66, 317-329.
67. Maione, S., Palazzo, E., de Novellis, V., Stella, L., Leyva, J. & Rossi, F. (1998a) Metabotropic glutamate receptors modulate serotonin release in the rat periaqueductal gray matter. N.-S. Arch. Pharmacol., 358, 411-417.
68. Maione, S., Marabese, I., Leyva, J., Palazzo, E., de Novellis, V. & Rossi, F. (1998b) Characterisation of mGluRs which modulate nociception in the PAG of the mouse. Neuropharmacology, 37, 1475-1483.
69. Maione, S., Oliva, P., Marabese, I., Palazzo, E., Rossi, F., Berrino, L. & Filippelli, A. (2000) Periaqueductal gray matter metabotropic glutamate receptors modulate formalin-induced nociception. Pain, 85, 183-189.
70. Marabese, I., de Novellis, V., Palazzo, E., Scafuro, M.A., Vita, D., Rossi, F. & Maione, S. (2007a) Effects of (S)-3, 4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology, 52, 253-262.
71. Marabese, I., Rossi, F., Palazzo, E., de Novellis, V., Starowicz, K., Cristino, L., Vita, D., Gatta, L., Guida, F., Di Marzo, V., Rossi, F. & Maione, S. (2007b) Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception. J. Neurophysiol., 98, 43-53.
72. McGaraughty, S. & Heinricher, M.M. (2002) Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity. Pain, 96, 153-162.
73. Meng, I.D., Manning, B.H., Martin, W.J. & Fields, H.L. (1998) An analgesia circuit activated by cannabinoids. Nature, 395, 381-383.
74. Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O., Lukic, S., Stoehr, N., Mombereau, C., Kuhn, R., McAllister, K.H., van der Putten, H., Cryan, J.F. & Flor, P.J. (2005) A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc. Natl. Acad. Sci. USA, 102, 18712-18717.
75. Moghaddam, B. & Adams, B.W. (1998) Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science, 281, 349-352.
76. Monhemius, R., Green, D.L., Roberts, M.H. & Azami, J. (2001) Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain. Neurosci. Lett., 298, 70-74.
77. Montana, M.C. & Gereau, R.W. (2011) Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation. Curr. Pharm. Biotechno., 12, 1681-1688.
78. Nakamura, M., Kurihara, H., Suzuki, G., Mitsuya, M., Ohkubo, M. & Ohta, H. (2010) Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. Bioorg. Med. Chem. Lett., 20, 726-729.
79. Neto, F.L. & Castro-Lopes, J.M. (2000) Antinociceptive effect of a group II metabotropic glutamate receptor antagonist in the thalamus of monoarthritic rats. Neurosci. Lett., 296, 25-28.
80. Neugebauer, V. (2001) Peripheral metabotropic glutamate receptors: fight the pain where it hurts. Trends Neurosci., 24, 550-552.
81. Neugebauer, V. & Carlton, S.M. (2002) Peripheral metabotropic glutamate receptors as drug targets for pain relief. Expert Opin. Ther. Tar., 6, 349-361.
82. Neugebauer, V. & Li, W. (2002) Processing of nociceptive mechanical and thermal information in central amygdala neurons with knee-joint input. J. Neurophysiol., 87, 103-112.
83. Neugebauer, V., Li, W., Bird, G.C., Bhave, G. & Gereau, R.W. (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J. Neurosci., 23, 52-63.
84. Noda, K., Anzai, T., Ogata, M., Akita, H., Ogura, T. & Saji, M. (2003) Antisense knockdown of spinal-mGluR1 reduces the sustained phase of formalin-induced nociceptive responses. Brain Res., 987, 194-200.
85. de Novellis, V., Mariani, L., Palazzo, E., Vita, D., Marabese, I., Scafuro, M., Rossi, F. & Maione, S. (2005) Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat. Neuroscience, 134, 269-281.
86. O'Connor, R.M. & Cryan, J.F. (2010) Role of metabotropic glutamate receptors in CNS disorders. In Siehler, S. & Milligan, G. (Eds), G Protein-Coupled Receptors. Structure, Signaling and Physiology. Cambridge University Press, Cambridge, pp. 321-379.
87. Palazzo, E., Marabese, I., de Novellis, V., Oliva, P., Rossi, F., Berrino, L., Rossi, F. & Maione, S. (2001) Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception. Neuropharmacology, 40, 319-326.
88. Palazzo, E., de Novellis, V., Marabese, I., Cuomo, D., Rossi, F., Berrino, L., Rossi, F. & Maione, S. (2002) Interaction between vanilloid and glutamate receptors in the central modulation of nociception. Eur. J. Pharmacol., 439, 69-75.
89. Palazzo, E., Genovese, R., Mariani, L., Siniscalco, D., Marabese, I., De Novellis, V., Rossi, F. & Maione, S. (2004) Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat. Eur. J. Pharmacol., 492, 169-176.
90. Palazzo, E., Fu, Y., Ji, G., Maione, S. & Neugebauer, V. (2008) Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors. Neuropharmacology, 55, 537-545.
91. Palazzo, E., Marabese, I., Soukupova, M., Luongo, L., Boccella, S., Giordano, C., de Novellis, V., Rossi, F. & Maione, S. (2011) Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain. J. Neurosci., 31, 4687-4697.
92. Palazzo, E., Luongo, L., de Novellis, V., Rossi, F., Marabese, I. & Maione, S. (2012a) Transient receptor potential vanilloid type 1 and pain development. Curr. Opin. Pharmacol., 12, 9-17.
93. Palazzo, E., Luongo, L., Bellini, G., Guida, F., Marabese, I., Boccella, S., Rossi, F., Maione, S. & de Novellis, V. (2012b) Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model. CNS Neurol. Disord.-Dr., 11, 148-161.
94. Palazzo, E., Marabese, I., Luongo, L., Boccella, S., Bellini, G., Giordano, M.E., Rossi, F., Scafuro, M., de Novellis, V. & Maione, S. (2013) Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol. Pain, 9, 44-55.
95. Palucha, A., Klak, K., Branski, P., van der Putten, H., Flor, P.J. & Pilc, A. (2007) Activation of the mGlu7 receptor elicits antidepressant-like effects in mice. Psychopharmacology, 194, 555-562.
96. Park, Y.K., Galik, J., Ryu, P.D. & Randic, M. (2004) Activation of presynaptic group I metabotropic glutamate receptors enhances glutamate release in the rat spinal cord substantia gelatinosa. Neurosci. Lett., 361, 220-224.
97. Pertovaara, A., Kontinen, V.K. & Kalso, E.A. (1997) Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat. Exp. Neurol., 147, 428-436.
98. Piomelli, D., Beltramo, M., Giuffrida, A. & Stella, N. (1998) Endogenous cannabinoid signaling. Neurobiol. Dis., 5, 462-473.
99. Pitcher, M.H., Ribeiro-da-Silva, A. & Coderre, T.J. (2007) Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. J. Comp. Neurol., 505, 412-423.
100. Prieto, G.J., Cannon, J.T. & Liebeskind, J.C. (1983) N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat. Brain Res., 261, 53-57.
101. Ren, W. & Neugebauer, V. (2010) Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1. Mol. Pain, 6, 93-106.
102. Ren, W., Palazzo, E., Maione, S. & Neugebauer, V. (2011) Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala. Neuropharmacology, 61, 1334-1344.
103. Reynolds, D.V. (1969) Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science, 164, 444-445.
104. Roozendaal, B., McReynolds, J.R., Van der Zee, E.A., Lee, S., McGaugh, J.L. & McIntyre, C.K. (2009) Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala. J. Neurosci., 29, 14299-14308.
105. Saab, C.Y., Wang, J., Gu, C., Garner, K.N. & Al-Chaer, E.D. (2007) Microglia: a newly discovered role in visceral hypersensitivity? Neuron Glia Biol., 2, 271-277.
106. Salling, M.C., Faccidomo, S. & Hodge, C.W. (2008) Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082. Pharmacol. Biochem. Be., 91, 14-20.
107. Salt, T.E. & Binns, K.E. (2000) Contributions of mGlu1 and mGlu5 receptors to interactions with N-methyl-D-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurons. Neuroscience, 100, 375-380.
108. Salt, T.E. & Eaton, S.A. (1995) Modulation of sensory neurone excitatory and inhibitory responses in the ventrobasal thalamus by activation of metabotropic excitatory amino acid receptors. Neuropharmacology, 34, 1043-1051.
109. Salt, T.E. & Turner, J.P. (1998) Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R, 4R-aminopyrrolidine-2, 4-dicarboxylate. Exp. Brain Res., 121, 181-185.
110. Sasamura, T., Sasaki, M., Tohda, C. & Kuraishi, Y. (1998) Existence of capsaicin-sensitive glutamatergic terminals in rat hypothalamus. NeuroReport, 9, 2045-2048.
111. Schouenborg, J. & Dickenson, A. (1985) Effects of a distant noxious stimulation on A and C fibre-evoked flexion reflexes and neuronal activity in the dorsal horn of the rat. Brain Res., 328, 23-32.
112. Shim, B., Kim, D.W., Kim, B.H., Nam, T.S., Leem, J.W. & Chung, J.M. (2005) Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. Neuroscience, 132, 193-201.
113. Soliman, A.C., Yu, J.S. & Coderre, T.J. (2005) mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity. Neuropharmacology, 48, 325-332.
114. Sukoff Rizzo, S.J., Leonard, S.K., Gilbert, A., Dollings, P., Smith, D.L., Zhang, M.Y., Di, L., Platt, B.J., Neal, S., Dwyer, J.M., Bender, C.N., Zhang, J., Lock, T., Kowal, D., Kramer, A., Randall, A., Huselton, C., Vishwanathan, K., Tse, S.Y., Butera, J., Ring, R.H., Rosenzweig-Lipson, S., Hughes, Z.A. & Dunlop, J. (2011) The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? J. Pharmacol. Exp. Ther., 338, 345-352.
115. Sun, H. & Neugebauer, V. (2011) mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making. J. Neurophysiol., 106, 960-973.
116. Suzuki, G., Tsukamoto, N., Fushiki, H., Kawagishi, A., Nakamura, M., Kurihara, H., Mitsuya, M., Ohkubo, M. & Ohta, H. (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J. Pharmacol. Exp. Ther., 323, 147-156.
117. Thomas, N.K., Wright, R.A., Howson, P.A., Kingston, A.E., Schoepp, D.D. & Jane, D.E. (2001) (S)-3, 4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology, 40, 311-318.
118. Turner, J.P. & Salt, T.E. (1999) Group III metabotropic glutamate receptors control corticothalamic synaptic transmission in the rat thalamus in vitro. J. Physiol., 519, 481-491.
119. Urban, M.O. & Gebhart, G.F. (1999) Supraspinal contributions to hyperalgesia. Proc. Natl. Acad. Sci. USA, 96, 7687-7692.
120. Valerio, A., Paterlini, M., Boifava, M., Memo, M. & Spano, P. (1997) Metabotropic glutamate receptor mRNA expression in rat spinal cord. NeuroReport, 8, 2695-2699.
121. Valtschanoff, J.G., Rustioni, A., Guo, A. & Hwang, S.J. (2001) Vanilloid receptor VR1 is both presynaptic and postsynaptic in the superficial laminae of the rat dorsal horn. J. Comp. Neurol., 436, 225-235.
122. Vardi, N., Duvoisin, R., Wu, G. & Sterling, P. (2000) Localization of mGluR6 to dendrites of ON bipolar cells in primate retina. J. Comp. Neurol., 423, 402-412.
123. Varney, M.A. & Gereau, R.W. IV. (2002) Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics. Curr. Drug Targets CNS Neurol. Disord., 1, 283-296.
124. Walker, K., Reeve, A., Bowes, M., Winter, J., Wotherspoon, G., Davis, A., Schmid, P., Gasparini, F., Kuhn, R. & Urban, L. (2001) mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurons mediate inflammatory hyperalgesia. Neuropharmacology, 40, 10-19.
125. Wang, Y.J. & Tseng, G.F. (2004) Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons. J. Neurotraum., 21, 479-489.
126. Wang, H., Jiang, W., Yang, R. & Li, Y. (2011) Metabotropic glutamate receptor 4 is involved in neuropathic pain. NeuroReport, 22, 244-248.
127. Yamada, T., Zuo, D., Yamamoto, T., Olszewski, R.T., Bzdega, T., Moffett, J.R. & Neale, J.H. (2012) Peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model inflammation. Mol. Pain, 12, 8-67.
128. Yamakura, T. & Shimoji, K. (1999) Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog. Neurobiol., 59, 279-298.
129. Yamamoto, T., Kozikowski, A., Zhou, J. & Neale, J.H. (2008) Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain. Mol. Pain, 1, 4-31.
130. Yang, D. & Gereau, R.W. IV. (2002) Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. J. Neurosci., 22, 6388-6393.
131. Yang, D. & Gereau, R.W. IV. (2003) Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation. Pain, 106, 411-417.
132. Young, M.R., Fleetwood-Walker, S.M., Mitchell, R. & Munro, F.E. (1994) Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons. Neuropharmacology, 33, 141-144.
133. Zammataro, M., Chiechio, S., Montana, M.C., Traficante, A., Copani, A., Nicoletti, F. & Gereau, R.W. IV. (2011) mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists. Mol. Pain, 14, 6-11.
134. Zhang, H.M., Chen, S.R. & Pan, H.L. (2009) Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience, 158, 875-884.
135. Zhou, S., Komak, S., Du, J. & Carlton, S.M. (2001) Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception. Brain Res., 913, 18-26.