Peripheral metabotropic glutamate receptors: Fight the pain where it hurts

Trends in Neurosciences

Volumn 24, Issue 10, 2001, Pages 550-552

  Neugebauer, Volker ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 HYDROXYPHENYLGLYCINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; 4 CARBOXY 2 METHYLPHENYLGLYCINE; 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CARBOXYLATE ETHYL ESTER; CALCIUM; CARBOXYLIC ACID DERIVATIVE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; IONOTROPIC RECEPTOR; LIGAND; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPASE C; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANALGESIA; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG TARGETING; INFLAMMATION; MUSCLE SPINDLE AFFERENT NERVE; NERVE ENDING; NOCICEPTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; SHORT SURVEY; THERMAL STIMULATION;

EID: 0035478759     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)02007-5     Document Type: Review

References (20)

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4. Knockdown of spinal metabotropic glutamate receptors 1 (mGluR1) alleviates pain and restores opioid efficacy after nerve injury in rats
5. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
6. Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells
7. Contributions of mGluR1 and mGluR5 receptors to interactions with N-methyl-D-aspartate receptor-mediated responses and nociceptive sensory responses of rat thalamic neurons
8. Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission
9. Peripheral excitatory amino acids
10. Peripheral group I metabotropic glutamate receptors modulate nociception in mice
11. Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons
12. The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neurons
13. Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons
14. Involvement of mGluR5 on acute nociceptive transmission
15. Metabotropic glutamate receptors: Novel targets for pain relief? Preclinical and clinical aspects
16. mGlu5 receptors and nociceptive function II. MGlu5 receptors functionally expressed on peripheral sensory neurons mediate inflammatory hyperalgesia
17. Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input
18. Formalin-evoked activity in identified primary afferent fibers: Systemic lidocaine suppresses phase-2 activity
19. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGluR5) antagonist, in experimental neuropathic pain in rats
20. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain