Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain

Neuroscience Letters

Volumn 298, Issue 1, 2001, Pages 70-74

  Monhemius, R ^a,c   Green, D L ^a   Roberts, M H T ^a   Azami, J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Central sensitisation; Descending inhibition; Nociception; Pain

Indexed keywords

4 AMINOBUTYRIC ACID; FORMALDEHYDE; HOMOCYSTEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; MALE; MICROINJECTION; NERVE LIGATION; NEUROPATHY; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SENSITIZATION;

ANIMALS; GAMMA-AMINOBUTYRIC ACID; HOMOCYSTEINE; LIGATION; MALE; MICROINJECTIONS; NEURAL INHIBITION; PAIN; PAIN MEASUREMENT; PERIAQUEDUCTAL GRAY; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; SCIATIC NERVE;

EID: 0035951675     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01627-X     Document Type: Article

References (22)

1. Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla
2. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
3. Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurones
4. NK1, NMDA, 5HT1a, and 5HT2 receptor binding sites in the rat lumbar spinal cord: Modulation following sciatic nerve crush
5. Plasticity in the spinal cord sensory map following peripheral nerve injury in rats
6. Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. II. Effects on medullary dorsal horn nociceptive and nonnociceptive neurons
7. The formalin test: A quantative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
8. Central nervous system mechanisms of pain modulation
9. Neurotransmitters in nociceptivemodulatory circuits
10. Brain-stem areas tonically inhibiting dorsal horn neurones: Studies with microinjection of the GABA analogue piperidine-4-sulphonic acid
11. Medullary raphe lesions do not reduce descending inhibition of dorsal horn neurones of the cat
12. The location of brainstem neurones tonically inhibiting dorsal horn neurones of the cat
13. Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: Behavioural observations and inhibitory effects on spinal cord interneurons
14. Supraspinal inhibition of nociceptive dorsal horn neurones in the anaesthetized rat: Tonic or dynamic?
15. Somatotopic redistribution of c-fos expressing neurons in the superficial dorsal horn after peripheral nerve injury
16. Surgery in the rat during electrical analgesia induced by focal brain stimulation
17. Effects of lesions in the anterolateral columns and dorsolateral funiculi on self-mutilation behaviour in rats
18. A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
19. Differential actions of the blockade of spinal opioid, adrenergic and serotonergic receptors on the tail-flick inhibition induced by morphine microinjected into dorsal raphe and central gray in rats
20. Evidence for a central component of post-injury pain hypersensitivity
21. The pathophysiology of chronic pain-increased sensitivity to low threshold A beta-fibre inputs