Antisense oligonucleotide knockdown of mGluR 1 alleviates hyperalgesia and allodynia associated with chronic inflammation

Pharmacology Biochemistry and Behavior

Volumn 73, Issue 2, 2002, Pages 401-410

  Fundytus, Marian E ^a,b,c,e   Osborne, Michael G ^c   Henry, James L ^a   Coderre, Terence J ^a,c,d   Dray, Andy ^b  

^a MCGILL UNIVERSITY   (Canada)

^b ASTRAZENECA   (United Kingdom)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e PURDUE PHARMA L P   (United States)

Author keywords

Allodynia; Antisense oligonucleotide; Hyperalgesia; Inflammation; Metabotropic glutamate receptor

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FREUND ADJUVANT; METABOTROPIC RECEPTOR; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE MODEL; DOSE TIME EFFECT RELATION; DRUG EFFECT; HYPERALGESIA; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; TIME; ANIMAL; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; DRUG ANTAGONISM; HEAT; INFLAMMATION; METABOLISM; PATHOLOGY; SPINAL CORD; STIMULATION; WESTERN BLOTTING; WISTAR RAT;

ANIMAL; BLOTTING, WESTERN; CHRONIC DISEASE; FREUND'S ADJUVANT; HEAT; HYPERALGESIA; INFLAMMATION; MALE; OLIGONUCLEOTIDES, ANTISENSE; PHYSICAL STIMULATION; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD; SUPPORT, NON-U.S. GOV'T; ANIMALS;

CELL FUSING AGENT VIRUS;

EID: 0035996507     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)00831-6     Document Type: Article

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