A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 51, 2005, Pages 18712-18717

  Mitsukawa, Kayo ^a   Yamamoto, Rina ^a   Ofner, Silvio ^a   Nozulak, Joachim ^a   Pescott, Oliver ^a   Lukic, Snezana ^a   Stoehr, Natacha ^a   Mombereau, Cedric ^a   Kuhn, Rainer ^a   McAllister, Kevin H ^a   Van Der Putten, Herman ^a   Cryan, John F ^a,b   Flor, Peter J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

G protein; mGluR

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 AMINO 4 METHYL 5 PHOSPHONO 3 PENTENOIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; AMN 082; CHIMERIC RECEPTOR; CORTICOSTERONE; CORTICOTROPIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 7 AGONIST; METABOTROPIC RECEPTOR 8; METABOTROPIC RECEPTOR AGONIST; N,N' DIBENZHYDRYLETHANE 1,2 DIAMINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; CHIMERA; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENETIC CONSERVATION; IN VIVO STUDY; MOLECULAR RECOGNITION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; BENZHYDRYL COMPOUNDS; CHO CELLS; CRICETINAE; HORMONES; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; STRESS;

ANIMALIA; MAMMALIA;

EID: 29444435620     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0508063102     Document Type: Article

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