Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain

NeuroReport

Volumn 22, Issue 5, 2011, Pages 244-248

  Wang, Hua ^a,b   Jiang, Wei ^a   Yang, Rui ^b   Li, Yong ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

AMN082; metabotropic glutamate receptor 4; metabotropic glutamate receptor 7; neuropathic pain; VU0155041

Indexed keywords

2 [((3,5 DICHLOROPHENYL)AMINO)CARBONYL]CYCLOHEXANEC ARBOXYLIC ACID SODIUM SALT; AMN 082; ANTINOCICEPTIVE AGENT; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR AGONIST; N,N' BIS(DIPHENYLMETHYL) 1,2 ETHANEDIAMINE DIHYDROCHLORIDE; UNCLASSIFIED DRUG; VU 0155041;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION;

ANILIDES; ANIMALS; BLOTTING, WESTERN; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; NEURALGIA; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 79952994442     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283453843     Document Type: Article

References (22)

1. Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999;353:1959-1964.
2. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999;83:389-400.
3. 2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain. Pain 1996;68:85-96. (Pubitemid 126407760)
4. Dougherty PM, Palecek J, Paleckova V, Sorkin LS, Willis WD. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. J Neurosci 1992;12:3025-3041.
5. Lavreysen H, Dautzenberg FM. Therapeutic potential of group III metabotropic glutamate receptors. Curr Med Chem 2008;15:671-684. (Pubitemid 351516803)
6. Schoepp DD, Jane DE, Monn JA. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999;38:1431-1476. (Pubitemid 29457728)
7. Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience 2009;158:875-884.
8. Goudet C, Chapuy E, Alloui A, Acher F, Pin JP, Eschalier A. Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain. Pain 2008;137:112-124. (Pubitemid 351802243)
9. Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured rats. J Pharmacol Exp Ther 2005;312:120-126.
10. Valerio A, Paterlini M, Boifava M, Memo M, Spano P. Metabotropic glutamate receptor mRNA expression in rat spinal cord. Neuroreport 1997;8:2695-2699. (Pubitemid 27373515)
11. Vardi N, Duvoisin R, Wu G, Sterling P. Localization of mGluR6 to dendrites of ON bipolar cells in primate retina. J Comp Neurol 2000;423:402-412. (Pubitemid 30451674)
12. Azkue JJ, Murga M, Fernandez-Capetillo O, Mateos JM, Elezgarai I, Benitez R, et al. Immunoreactivity for the group III metabotropic glutamate receptor subtype mGluR4a in the superficial laminae of the rat spinal dorsal horn. J Comp Neurol 2001;430:448-457. (Pubitemid 32105762)
13. Li JL, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, et al. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Neurosci Lett 1996;204:9-12. (Pubitemid 26053665)
14. Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A 2005;102:18712-18717. (Pubitemid 43011291)
15. Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, et al. Discovery, characterization, and anti-Parkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol 2008;74:1345-1358.
16. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992;50:355-363.
17. Mestre C, Pelissier T, Fialip J, Wilcox G, Eschalier A. A method to perform direct transcutaneous intrathecal injection in rats. J Pharmacol Toxicol Methods 1994;32:197-200.
18. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994;53:55-63. (Pubitemid 24238751)
19. Hargreaves K, Dubner R, Brown F, Flores C, Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988;32:77-88.
20. Schoepp DD. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 2001;299:12-20. (Pubitemid 32905113)
21. Chavis P, Mollard P, Bockaert J, Manzoni O. Visualization of cyclic AMP-regulated presynaptic activity at cerebellar granule cells. Neuron 1998;20:773-781. (Pubitemid 28199055)
22. Dolan S, Gunn MD, Biddlestone L, Nolan AM. The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. Behav Pharmacol 2009;20:596-604.