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Volumn 545, Issue , 2014, Pages 100-107

The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes

(5) Jang, Hyun Hee a Davydov, Dmitri R a Lee, Ga Young b Yun, Chul Ho b Halpert, James R a

a UNIVERSITY OF CALIFORNIA SAN DIEGO (United States)

b Chonnam National University (South Korea)

Author keywords

Amlodipine; Cytochrome P450 2B4 and 2B6; Spectral titrations; Substrate access channel 2f and 2a

Indexed keywords

7 ETHOXY 4 (TRIFLUOROMETHYL)COUMARIN; AMLODIPINE; BENZYLOXYRESORUFIN; COUMARIN; CYTOCHROME P450 2B4; CYTOCHROME P450 2B6; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; LIGAND BINDING; OXIDATION; PRIORITY JOURNAL; SPECTROSCOPY; STEADY STATE; TITRIMETRY;

AMLODIPINE; CYTOCHROME P450 2B4 AND 2B6; SPECTRAL TITRATIONS; SUBSTRATE ACCESS CHANNEL 2F AND 2A;

AMLODIPINE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CATALYTIC DOMAIN; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; RABBITS;

EID: 84893328615 PISSN: 00039861 EISSN: 10960384 Source Type: Journal
DOI: 10.1016/j.abb.2014.01.008 Document Type: Article

Times cited : (14)

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