Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules

Biochemistry

Volumn 51, Issue 37, 2012, Pages 7225-7238

  Shah, Manish B ^a   Wilderman, P Ross ^a   Pascual, Jaime ^b   Zhang, Qinghai ^b   Stout, C David ^b   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMLODIPINE; BINDING CAVITY; CALCIUM CHANNEL BLOCKERS; CONFORMATIONAL STATE; CYTOCHROME P450; DRUG MOLECULES; HUMAN CYTOCHROME; IN-SILICO; ITRACONAZOLE; KEY RESIDUES; PROTEIN SURFACE;

MOLECULES; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

CONFORMATIONS;

AMLODIPINE BESYLATE; CYTOCHROME P450 2B4; CYTOCHROME P450 2B6; IMIDAZOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BETA SHEET; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; HUMAN; HUMAN CELL; MOLECULE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMLODIPINE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CALCIUM CHANNEL BLOCKERS; CRYSTALLOGRAPHY, X-RAY; HUMANS; OXIDOREDUCTASES, N-DEMETHYLATING; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RABBITS; SUBSTRATE SPECIFICITY;

ORYCTOLAGUS CUNICULUS;

EID: 84866389270     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300894z     Document Type: Article

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