Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6797-6809

  Davydov, Dmitri R ^a   Rumfeldt, Jessica A O ^a   Sineva, Elena V ^a   Fernando, Harshica ^b   Davydova, Nadezhda Y ^a   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERY; CONFORMATIONAL TRANSITIONS; COOPERATIVITY; CYTOCHROME P450-3A4; CYTOCHROMES P450; DRUG-METABOLIZING ENZYMES; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-AFFINITY BINDING SITES; LASER DYES; LIGAND BINDING; LIGAND-BINDING SITES; MODEL SUBSTRATES; SHIFT-AND; SPATIAL LOCALIZATION;

BINDING SITES; ENZYMES; FLUORESCENCE; LIGANDS; PROBES;

ENERGY TRANSFER;

CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN MODIFICATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BINDING SITES; CATALYTIC DOMAIN; CYSTEINE; CYTOCHROME P-450 CYP3A; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; ISOQUINOLINES; LIGANDS; MODELS, CHEMICAL; MUTAGENESIS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TITRIMETRY;

EID: 84857473710     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.325654     Document Type: Article

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