Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis

Biochemistry

Volumn 52, Issue 2, 2013, Pages 355-364

  Zhang, Haoming ^a   Gay, Sean C ^b,d   Shah, Manish ^b   Foroozesh, Maryam ^c   Liu, Jiawang ^c   Osawa, Yoichi ^a   Zhang, Qinghai ^d   Stout, C David ^d   Halpert, James R ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c XAVIER UNIVERSITY OF LOUISIANA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC MODULATION; ALLOSTERIC SITE; CATALYTIC SITES; COVALENT MODIFICATIONS; CYTOCHROME P450; ENZYME INACTIVATION; ESTER BONDS; HIGH-AFFINITY SITES; HILL COEFFICIENT; HOMOTROPIC COOPERATIVITY; MOLECULAR DYNAMICS SIMULATIONS; PARTITION RATIOS; PROTEIN MODIFICATIONS;

ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PIGMENTS; X RAY CRYSTALLOGRAPHY;

PROTEINS;

9 ETHYNYLPHENANTHRENE; CYTOCHROME P450 2B4; PHENANTHRENE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIBODY COMBINING SITE; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; COVALENT BOND; ELECTROSPRAY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME PURIFICATION; ENZYME STRUCTURE; HILL REACTION; MASS FRAGMENTOGRAPHY; MODULATION; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN MODIFICATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; KINETICS; MOLECULAR DOCKING SIMULATION; PHENANTHRENES; PROTEIN BINDING; PROTEIN CONFORMATION; RABBITS;

EID: 84872526198     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301567z     Document Type: Article

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