Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10613-10622

  Zhao, Bin ^a   Lei, Li ^a   Kagawa, Norio ^b   Sundaramoorthy, Munirathinam ^a   Banerjee, Surajit ^a   Nagy, Leslie D ^a   Guengerich, F Peter ^a   Waterman, Michael R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

17-HYDROXYPROGESTERONE; ACTIVE SITE; CLINICAL DATA; CONGENITAL ADRENAL HYPERPLASIAS; CYTOCHROME P450; EFFECTS OF AMINO ACIDS; METABOLIC DISORDERS; MOLECULAR BASIS; STRUCTURE/FUNCTION RELATIONSHIPS; SUBSTRATE BINDING; SUBSTRATE RECOGNITION; THREE-DIMENSIONAL STRUCTURE;

AMINO ACIDS; ENZYMES; FEATURE EXTRACTION; PORPHYRINS;

SUBSTRATES;

ALDOSTERONE; ANDROGEN; ENZYME VARIANT; HYDROCORTISONE; HYDROXYPROGESTERONE; STEROID 21 MONOOXYGENASE;

ANDROGEN SYNTHESIS; ARTICLE; BINDING AFFINITY; CONGENITAL ADRENAL HYPERPLASIA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME LOCALIZATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RESIDUE ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

17-ALPHA-HYDROXYPROGESTERONE; ADRENAL HYPERPLASIA, CONGENITAL; ANIMALS; BINDING SITES; CATTLE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTATION; STEROID 21-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 84858976886     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323501     Document Type: Article

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