Mapping of cytochrome P450 2B4 substrate binding sites by photolabile probe 3-azidiamantane: Identification of putative substrate access regions

Archives of Biochemistry and Biophysics

Volumn 468, Issue 1, 2007, Pages 82-91

  Hodek, Petr ^a   Karabec, Martin ^a   Šulc, Miroslav ^a,b   Sopko, Bruno ^c   Smrček, Stanislav ^a   Martínek, Václav ^a   Hudeček, Jiří ^a   Stiborová, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^c CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

Author keywords

Access channel; CYP2B4; Diamantane; Enzyme structure; Photoaffinity labeling

Indexed keywords

3 AZIDIAMANTANE; AMANTADINE DERIVATIVE; ARGININE; CYTOCHROME P450 2B4; HEME; LEUCINE; LYSINE; PHENYLALANINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHIMERA; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; RABBIT; SIMULATION;

ADAMANTANE; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; COMPUTER SIMULATION; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOTOCHEMISTRY; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

ORYCTOLAGUS CUNICULUS;

EID: 36048953952     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.09.017     Document Type: Article

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