Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target

Nucleic Acids Research

Volumn 42, Issue 2, 2014, Pages 1270-1290

  Tomecki, Rafal ^a,b   Drazkowska, Karolina ^a,b   Kucinski, Iwo ^a,b   Stodus, Krystian ^a,b   Szczesny, Roman J ^a,b   Gruchota, Jakub ^a,b,c   Owczarek, Ewelina P ^a,b   Kalisiak, Katarzyna ^a,b   Dziembowski, Andrzej ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

^c INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR RNA; NUCLEASE; PROTEIN HDIS3L; PROTEIN HRRP6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL PROLIFERATION; CELL SURVIVAL; CHICKEN; CONTROLLED STUDY; EMBRYO; EXOSOME; GENE; GENE MUTATION; HDIS3 GENE; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA METABOLISM; YEAST CELL;

ANIMALS; CATALYTIC DOMAIN; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX; HEK293 CELLS; HUMANS; MULTIPLE MYELOMA; MUTATION; PHENOTYPE; RNA; RNA STABILITY; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84893317824     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt930     Document Type: Article

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