A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Pils, Dietmar ^a,b   Tong, Dan ^a   Hager, Gudrun ^a   Obermayr, Eva ^a   Aust, Stefanie ^a   Heinze, Georg ^c   Kohl, Maria ^c   Schuster, Eva ^a   Wolf, Andrea ^a   Sehouli, Jalid ^d   Braicu, Ioana ^d   Vergote, Ignace ^e   Van Gorp, Toon ^e,f   Mahner, Sven ^g   Concin, Nicole ^h   Speiser, Paul ^a   Zeillinger, Robert ^a,b  

^a UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^g UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^h INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Biomarker; Diagnosis; Ovarian cancer; Peripheral blood leukocytes; Plasma protein; Transcriptomics

Indexed keywords

CA 125 ANTIGEN; LEPTIN; MACROPHAGE MIGRATION INHIBITION FACTOR; OSTEOPONTIN; PLASMA PROTEIN; PROLACTIN; SOMATOMEDIN B;

ADULT; AGED; AP2A1 GENE; ARTICLE; B4GALT1 GENE; BC037918 GENE; BLOOD ANALYSIS; C1ORF63 GENE; CANCER GRADING; CCR2 GENE; CFP GENE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTADENOMA; DIS3 GENE; EARLY DIAGNOSIS; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; NEAT1 GENE; NOXA1 GENE; OSM GENE; OVARY CARCINOMA; PAPOLG GENE; PRIC285 GENE; PROTEIN ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; ZNF419 GENE;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; AREA UNDER CURVE; BLOOD PROTEINS; CA-125 ANTIGEN; CASE-CONTROL STUDIES; CYSTADENOMA; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INSULIN-LIKE GROWTH FACTOR II; INTRAMOLECULAR OXIDOREDUCTASES; LEPTIN; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOPONTIN; OVARIAN NEOPLASMS; PROLACTIN; RETROSPECTIVE STUDIES; ROC CURVE; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84875662614     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-178     Document Type: Article

References (21)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009, 59(4):225-249. 10.3322/caac.20006, 19474385.
2. Heintz AP, Odicino F, Maisonneuve P, Quinn MA, Benedet JL, Creasman WT, Ngan HY, Pecorelli S, Beller U. Carcinoma of the ovary. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet 2006, 95(Suppl 1):S161-S192.
3. Bast RC, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 1981, 68(5):1331-1337. 10.1172/JCI110380, 370929, 7028788.
4. Jacobs IJ, Menon U. Progress and challenges in screening for early detection of ovarian cancer. Mol Cell Proteomics 2004, 3(4):355-366. 10.1074/mcp.R400006-MCP200, 14764655.
5. Moore RG, Maclaughlan S. Current clinical use of biomarkers for epithelial ovarian cancer. Curr Opin Oncol 2010, 22(5):492-497. 10.1097/CCO.0b013e32833c3351, 20613519.
6. Mabuchi S, Kimura T. Treatment of ovarian cancer by monoclonal antibodies. Discov Med 2010, 9(46):197-203.
7. Zhang Z, Bast RC, Yu Y, Li J, Sokoll LJ, Rai AJ, Rosenzweig JM, Cameron B, Wang YY, Meng XY. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res 2004, 64(16):5882-5890. 10.1158/0008-5472.CAN-04-0746, 15313933.
8. Ueland FR, Desimone CP, Seamon LG, Miller RA, Goodrich S, Podzielinski I, Sokoll L, Smith A, van Nagell JR, Jr Zhang Z. Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors. Obstet Gynecol 2011, 117(6):1289-1297. 10.1097/AOG.0b013e31821b5118, 21606739.
9. Ware Miller R, Smith A, DeSimone CP, Seamon L, Goodrich S, Podzielinski I, Sokoll L, van Nagell JR, Jr Zhang Z, Ueland FR. Performance of the American college of obstetricians and gynecologists' ovarian tumor referral guidelines with a multivariate index assay. Obstet Gynecol 2011, 117(6):1298-1306. 10.1097/AOG.0b013e31821b1d80, 21555961.
10. Mor G, Visintin I, Lai Y, Zhao H, Schwartz P, Rutherford T, Yue L, Bray-Ward P, Ward DC. Serum protein markers for early detection of ovarian cancer. Proc Natl Acad Sci USA 2005, 102(21):7677-7682. 10.1073/pnas.0502178102, 1140439, 15890779.
11. Visintin I, Feng Z, Longton G, Ward DC, Alvero AB, Lai Y, Tenthorey J, Leiser A, Flores-Saaib R, Yu H. Diagnostic markers for early detection of ovarian cancer. Clin Cancer Res 2008, 14(4):1065-1072. 10.1158/1078-0432.CCR-07-1569, 18258665.
12. Yurkovetsky Z, Skates S, Lomakin A, Nolen B, Pulsipher T, Modugno F, Marks J, Godwin A, Gorelik E, Jacobs I. Development of a multimarker assay for early detection of ovarian cancer. J Clin Oncol 2010, 28(13):2159-2166. 10.1200/JCO.2008.19.2484, 2860434, 20368574.
13. Sharma P, Sahni NS, Tibshirani R, Skaane P, Urdal P, Berghagen H, Jensen M, Kristiansen L, Moen C, Zaka A. Early detection of breast cancer based on gene-expression patterns in peripheral blood cells. Breast Cancer Res 2005, 7(5):R634-R644. 10.1186/bcr1203, 1242124, 16168108.
14. Aaroe J, Lindahl T, Dumeaux V, Saebo S, Tobin D, Hagen N, Skaane P, Lonneborg A, Sharma P, Borresen-Dale AL. Gene expression profiling of peripheral blood cells for early detection of breast cancer. Breast Cancer Res 2010, 12(1):R7. 10.1186/bcr2472, 2880427, 20078854.
15. Brandt B, Griwatz C. Two-layer buoyant density centrifugation gradient for enrichment of prostate-derived cells and cell clusters from peripheral blood. Clin Chem 1996, 42(11):1881-1882.
16. Yeung KY, Bumgarner RE. Multiclass classification of microarray data with repeated measurements: application to cancer. Genome Biol 2003, 4(12):R83. 10.1186/gb-2003-4-12-r83, 329422, 14659020.
17. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, Howe EA, Li J, Thiagarajan M, White JA, Quackenbush J. TM4 microarray software suite. Methods Enzymol 2006, 411:134-193.
18. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001, 98(9):5116-5121. 10.1073/pnas.091062498, 33173, 11309499.
19. Park MY, Hastie T. L-1-regularization path algorithm for generalized linear models. J Roy Stat Soc B 2007, 69:659-677.
20. Efron B, Tibshirani R. Improvements on cross-validation: The.632+ bootstrap method. J Am Stat Assoc 1997, 92(438):548-560.
21. Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003, 3(11):900-911. 10.1038/nri1226, 14668806.