Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma

PLoS Neglected Tropical Diseases

Volumn 5, Issue 5, 2011, Pages

  Hobbie, Sven N ^a,d   Kaiser, Marcel ^b,c   Schmidt, Sebastian ^a,e   Shcherbakov, Dmitri ^a   Janusic, Tanja ^a   Brun, Reto ^b,c   Böttger, Erik C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^e Roche Diagnostics Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NEOMYCIN; PAROMOMYCIN; RNA 16S; TOBRAMYCIN; ANTIPROTOZOAL AGENT; BACTERIAL RNA; PROTOZOAL RNA; RIBOSOME RNA;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFICACY; DRUG TARGETING; FEMALE; GENETIC ANALYSIS; IN VITRO STUDY; LEISHMANIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; RIBOSOME; RNA SEQUENCE; RNA STRUCTURE; SEQUENCE ANALYSIS; TRYPANOSOMA BRUCEI; ANIMAL; DISEASE MODEL; DRUG EFFECT; DRUG SENSITIVITY; GENETIC RECOMBINATION; GENETICS; METABOLISM; PARASITOLOGY; PROTEIN SYNTHESIS; RODENT DISEASE;

ANIMALS; ANTIPROTOZOAL AGENTS; DISEASE MODELS, ANIMAL; FEMALE; LEISHMANIA; MICE; PARASITIC SENSITIVITY TESTS; PAROMOMYCIN; PROTEIN BIOSYNTHESIS; RECOMBINATION, GENETIC; RNA, BACTERIAL; RNA, PROTOZOAN; RNA, RIBOSOMAL; RODENT DISEASES; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 79958007665     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001161     Document Type: Article

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