Aminoglycoside antibiotics

Audiology and Neuro-Otology

Volumn 5, Issue 1, 2000, Pages 3-22

  Forge, Andrew ^a   Schacht, Jochen ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Aminoglycosides; Mechanism of action; Ototoxicity; Pharmacokinetics; Prevention; Reactive oxygen species

Indexed keywords

ACETYLSALICYLIC ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANALGESIC AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ARSPHENAMINE; CISPLATIN; DIHYDROSTREPTOMYCIN; EFLORNITHINE; ETACRYNIC ACID; FUROSEMIDE; GENTAMICIN; LOOP DIURETIC AGENT; ORGANOTIN COMPOUND; QUININE; SALICYLIC ACID; STREPTOMYCIN; TOLUENE; VANCOMYCIN; VIOMYCIN;

ANTIBIOTIC SENSITIVITY; ANTIOXIDANT ACTIVITY; GENE MUTATION; HEARING LOSS; HUMAN; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PATHOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; TUBERCULOSIS; VESTIBULAR DISORDER;

EID: 0033965367     PISSN: 14203030     EISSN: None     Source Type: Journal    
DOI: 10.1159/000013861     Document Type: Review

References (193)

1. Aran JM, Darrouzet J: Observation of click-evoked compound VIII nerve responses before, during, and over seven months after kanamycin treatment in the guinea pig. Acta Otolaryngol (Stockh) 1975;79:24-32.
2. Aran JM, Dulon D, Hiel H, Erre JP, Aurousseau C: L'ototoxicité d'aminosides: résultats récents sur la captation et la clairance de la gentamicine par les cellules sensorielles du limacon osseux. Rev Laryngol Otol Rhinol (Bord) 1993; 114:125-128.
3. Aruoma OI, Kaur H, Halliwell B: Oxygen free radicals and human diseases. J R Soc Health 1991; 111:172-177.
4. Balogh K, Hiraide F, Ishii D: Distribution of radioactive dihydrostreptomycin in the cochlea. Ann Otol Rhinol 1970;79:641-652.
5. Barber DA, Harris SR: Oxygen free radicals and antioxidants: A review. Am Pharm 1994;NS34: 26-35.
6. Barton-Davis ER, Cordier L, Shoturma DI, Leland SE, Sweeney HL: Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J Clin Invest 1999;375-381.
7. Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P: N-Methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nat Med 1996;12:1338-1343.
8. Bernard PA: Freedom from ototoxicity in aminoglycoside treated neonates: A mistaken notion. Laryngoscope 1981;91:1985-1994.
9. Bernard PA, Péchèrc JC, Hébert R: Altered objective audiometry in aminoglycosides-treated human neonates. Arch Otorhinolaryngol 1980; 228:205-210.
10. Blakley BW: Clinical forum: A review of intratympanic therapy. Am J Otol 1997;18:520-526.
11. Blanchard SC, Fourmy D, Eason RG, Puglisi JD: rRNA chemical groups required for aminoglycoside binding. Biochemistry 1998;37:7716-7724.
12. Bock GR, Yates GK, Miller JJ, Moorjani P: Effects of N-acetylcysteine on kanamycin ototoxicity in the guinea pig. Hear Res 1983;9:255-262.
13. Brouet G, Marche J, Chevallier J, Liot F, Le Meur G, Bergogne Mme: Étude expérimentale et clinique de la kanamycine dans l'infection tuberculeuse. Rev Tub Pneum 1959;23:949-988.
14. Brown AM, McDowell B, Forge A: Acoustic distortion products can be used to monitor the effects of chronic gentamicin treatment. Hear Res 1989;42:143-156.
15. Brown JJ, Brummen RE, Fox KE, Bendrick TW: Combined effects of noise and kanamycin: Cochlear pathology and pharmacology. Arch Otolaryngol 1980;106:744-750.
16. Brummet RE, Fox KE: Studies of aminoglycoside ototoxicity in animal models; in Welton A, Neu HC (eds): The Aminoglycosides. Microbiology, Clinical Use and Toxicology. New York, Marcel Dekker Inc., 1982, pp 419-451.
17. Capps MJ, Duvall AJ: Ototoxicity and the olivo-cochlear bundle. Laryngoscope 1977;87:1100-1108.
18. Caussé R, Gondet I, Vallancien B: Action de la streptomycine sur les cellules cilićes des organes vestibulaires de la souris. C R Soc Biol 1949;143:619-620.
19. Chernov MV, Stark GR: The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate. Oncogene 1997;14: 2503-2510.
20. Clerici WJ, Hensley K, DiMartino DL, Butterfield DA: Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996;98:116-124.
21. Conlon BJ, Aran J-M, Erre J-P. Smith, DW: Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant α-lipoic acid. Hear Res 1999;128:40-44.
22. Conlon BJ, Smith DW: Attenuation of neomycin ototoxicity by iron chelation. Laryngoscope 1998a;108:284-287.
23. Conlon BJ, Smith DW: Supplemental iron exacerbates aminoglycoside ototoxicity in vivo. Hear Res 1998b;115:1-5.
24. Corrado AP, de Morais IP, Prado WA: Aminoglycoside antibiotics as a tool for the study of the biological role of calcium ions: Historical overview. Acta Physiol Pharmacol Latinoam 1989; 39:419-430.
25. Crann SA, Huang MY, McLaren JD, Schacht J: Formation of a toxic metabolite from gentamicin by a hepatic cytosolic fraction. Biochem Pharmacol 1992;43:1835-1839.
26. Darrouzet J, Guilhaume A: Ototoxicité de la kanamycine au jour le jour: Étude expérimentale en microscopic électronique. Rev Laryngol (Bord) 1974;95:601-621.
27. Davis BD: Mechanism of bactericidal action of aminoglycosides. Microbiol Rev 1987;51:341-350.
28. Davis H, Deatherage BH, Ronsenblut B, Fernández C, Kimura R, Smith CA: Modification of cochlear potentials produced by streptomycin poisoning and by extensive venous obstruction. Laryngoscope 1958;68:596-627.
29. De Groot JC, Meeuwsen F, Ruizendaal WE, Veldman JE: Ultrastructural localization of gentamicin in cochlea, Hear Res 1990;50:35-42.
30. Dinis TC, Maderia VM, Almeida LM: Action of phenolic derivatives (acetaminophen, salicylatc, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys 1994;315:161-169.
31. Duckert LG, Rubel EW: Morphological correlates of functional recovery in the chicken inner car after gentamicin treatment. J Comp Neurol 1993;331:75-96.
32. Dulon D, Aran JM, Zajic G, Schacht J: Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrob Agents Chemother 1986;30:96-100.
33. Dulon D, Aurousseau C, Erre JP, Aran JM: Relationship between the nephrotoxicity and ototoxicity induced by gentamicin in the guinea pig. Acta Otolaryngol 1988;106:219-225.
34. Dulon D, Zajic G, Aran J-M, Schacht J: Aminoglycoside antibiotics impair calcium-entry but not viability and motility of cochlcar outer hair cells. J Neurosci Res 1989;24:338-346.
35. Edson RS, Terrell CL: The aminoglycosides. Mayo Clin Proc 1999;74:519-528.
36. Edwards J: Species Differences in Susceptibility to Aminoglycoside Ototoxicity; MSc thesis University College London, 1997.
37. Ernfors P, Duan ML, El Shamy WM. Canlon B: Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Nat Med 1996;2:463-467.
38. Fausti SA, Rappaport BZ, Schechter MA, Frey RH, War TT, Brummett RE: Detection of aminoglycoside ototoxicity by high freqency auditory evaluation: Selected case studies. Am J Otolaryngol 1984;5:177-182.
39. Fee WE: Aminoglycoside ototoxicity in the human. Laryngoscope 1980;40:1-19.
40. Forge A: Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment. Hear Res 1985;19:171-182.
41. Forge A. Fradis M: Structural abnormalities in the stria vascularis following chronic gentamicin treatment. Hear Res 1985;20:233-244.
42. Forge A, Li L: Apoptotic death of hair cells in the mammalian vestibular sensory epithelia. Hear Res 2000;139:97-115.
43. Forge A, Li L, Corwin JT, Nevill G: Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science 1993;259:1616-1619.
44. Forge A, Li L, Nevill G: Hair cell recovery in the vestibular sensory epithelia of mature guinea pigs. J Comp Neurol 1998;397:69-88.
45. Forge A, Richardson G: Freeze-fracture analysis of apical membranes in cochlear cultures: Differences between basal and apical-coil outer hair cells and effects of neomycin. J Neurocytol 1993;22:854-867.
46. Forge A, Wright A, Davies SJ: Analysis of structural changes in the stria vascularis following chronic gentamicin treatment. Hear Res 1987; 31:253-266.
47. Gao WQ: Therapeutic potential of neurotrophins for treatment of hearing loss. Mol Neurobiol 1998;17:17-31.
48. Garetz SL, Altschuler RA, Schacht J: Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear Res 1994a;77:81-87.
49. Garetz SL, Rhee DJ, Schacht J: Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear Res 1994b;77:75-80.
50. Garetz SL, Schacht J: Ototoxicity: Of mice and men; in Van De Water TR, Fay RR, Popper AN (eds): Clinical Aspects of Hearing. Handbook of Auditory Research. New York, Springer, 1996, vol VII, pp 116-154.
51. Gitter AH, Oliver D, Thurm U: Streptomycin inhibits discharge in Hydra vulgaris by blockage of mechanosensitivity. Naturwissenschaften 1993;80:273-276.
52. Hashino E, Shero M, Salvi RJ: Lysosomal targetting and accumulation of aminoglycoside antibiotics in sensory hair cells. Brain Res 1997; 777:75-85.
53. Hashino E, Tanaka Y, Sokabe: Hair cell damage and recovery following chronic application of kanamycin in the chick cochlea. Hear Res 1991;52:356-368.
54. Hawkins JE: Cochlcar signs of streptomycin intoxication. J Pharmacol Exp Ther 1950;100:38-44.
55. Hawkins JE: Ototoxic mechanisms: A working hypothesis. Audiology 1973;12:383-393.
56. Hawkins JE: Drug otoloxicity; in Keidel WD, Neff WD (eds): Handbook of Sensory Physiology. Berlin, Springer, 1976, vol 5, part 3, pp 707-748.
57. Hawkins JE, Beger V, Aran J-M: Antibiotic insults to Corti's organ: in Graham AB (ed): Sensorineural Hearing Processes and Disorders. Boston, Little Brown, 1967, pp 411-425.
58. Hawkins JE, Johnsson L-G: Histopathology of cochlear and vestibular ototoxicity in laboratory animals: in Lerner SA, Matz GJ, Hawkins JE Jr (eds): Aminoglycoside Ototoxicity. Boston, Little Brown, 1981, pp 175-195.
59. Hawkins JE, Stebbins WC, Johnsson L-G, Moody DB, Muraski A: The patas monkey as a model for dihydrostreptomycin ototoxicity. Acta Otolaryngol 1977;83:123-129.
60. Hayashida T, Hiel H, Dulon D, Erre J-P, Guilhaume A, Aran J-M: Dynamic changes following combined treatment with gentamicin and ethacrynic acid with and without acoustic stimulation: Cellular uptake and functional correlates. Acta Otolaryngol 1989;108:404-413.
61. Hayashida T, Nomura Y, Iwamori M, Nagai Y, Kurata T: Distribution of gentamicin by immunofluorescence in the guinea pig inner ear. Arch Otorhinolaryngol 1985;242:257-264.
62. Henley ChM, Gerhardt HJ, Schacht J: Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Res Bull 1987;19:695-698.
63. Henley ChM, Schacht J: Pharmacokinetics of aminoglycoside antibiotics in blood, inner ear fluids and tissues and their relationship to ototoxicity. Audiology 1988;27:137-146.
64. Hennebert PE: Traitement par le BAL de l'intoxication labyrinthique par la streptomycine. Ann Otolaryngol (Paris) 1951;68:507-508.
65. Henry KR, Choie RA, McGinn MD, Frush DP: Increased ototoxicity in both young and old mice. Arch Otolaryngol 1981;107:92-95.
66. Hershko C: Iron chelators in medicine. Mol Aspects Med 1992;13:113-165.
67. Hiel H, Erre J, Aurousseau C, Bouali R, Dulon D, Aran JM: Gentamicin uptake by cochlear hair cells precedes hearing impairment during chronic treatment. Audiology 1993;32:78-87.
68. Hiel H, Schamel A, Erre JP, Hayashida T, Dulon D and Aran J-M: Cellular and subcellular localisation of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid. Hearing Res 1992;57:157-165.
69. Hinojosa R, Lerner SA: Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. J Infect Dis 1987; 156:449-555.
70. Hinshaw HC, Feldman WH: Streptomycin in treatment of clinical tuberculosis: A preliminary report. Proc Mayo Clin 1945;20:313-318.
71. Hirose K, Hockenberry DN, Rubel EW: Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 1997;104:1-14.
72. Hoffman DW, Whitworth CA, Jones-King KL, Rybak LP: Potentiation of ototoxicity by glutathione depletion. Ann Otol Rhinol Laryngol 1988;97:36-41.
73. Howard M, Frizzell RA, Bedwell DM: Aminoglycoside antibiotics restore CFTR function by overcoming premature stop codons. Nat Med 1996;2:467-469.
74. Huang MY, Schacht J: Formation of a cytotoxic metabolite from gentamicin by liver. Biochem Pharmacol 1990;40:R11-R14.
75. Hughes RA, O'Leary PD: Neurotrophic factors and the development of drugs to promote motoneuron survival. Clin Exp Pharmacol Physiol 1996;23:965-969.
76. Janas JD, Cotanche DA, Rubel EW: Avian cochlear hair cell regeneration: Stereological analyses of damage and recovery from a single high dose of gentamicin. Hear Res 1995;92:17-29.
77. Johnsson LG, Hawkins JE, Kingsley TC, Black FO, Matz GJ: Aminoglycoside-induced cochlear pathology in man. Acta Otolaryngol 1981; S383:1-19.
78. Kanno H, Yamanobe S, Rybak LP: The ototoxicity of deferoxamine mesylate. Am J Otolaryngol 1995;16:148-152.
79. Keller H, Krüpe W, Sous H, Mückter H: Versuche zur Toxizitätsminderung basischer Streptomyces-Antibiotika. 3. Mitteilung: Zum Mechanismus der Streptomycin-Vergiftung und ihre Becinflussbarkeit durch Pantothensäure. Arzneimittel-Forschung 1956;6:379-384.
80. Knight JA: Diseases related to oxygen-derived free radicals. Ann Clin Lab Sci 1995;25:111-121.
81. Komune S, Ide M, Nakano T, Morimitsu T: Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions. ORL 1987;49:9-16.
82. Kossl M, Richardson GP, Russell IJ: Stereocilia bundle stiffness: Effects of neomycin, A23187 and concanavalin A. Hear Res 1990;44:217-230.
83. Kotecha B, Richardson GP: Ototoxicity in vitro: Effects of neomycin, gentamicin, dihydrostreptomycin, amikacin, spectinomycin, neamine, spermine and poly-L-lysine. Hear Res 1994;73: 173-184.
84. Kroese ABA, van den Bercken J: Effects of ototoxic antibiotics on sensory hair cell functioning. Hear Res 1982;6:183-197.
85. Kroese ABA, Das A, Hudspeth AJ: Blockage of the transduction channels of hair cells in the bull frog's sacculus by aminoglycoside antibiotics. Hear Res 1989;37:203-218.
86. Kuramochi H, Takahashi K, Takita T, Umezawa H: An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen. J Antibiot (Tokyo) 1981;34:576-582.
87. Lautermann J, McLaren J, Schacht J: Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear Res 1995;86: 15-24.
88. Leake PA, Hradek GT: Cochlear pathology of long term neomycin induced deafness in cats. Hear Res 1988;33:11-33.
89. Leonova EV, Raphael Y: Organization of cell junctions and the cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of Corti. Hear Res 1997;113:14-28.
90. Lerner SA, Schmitt BA, Seligsohn R, Matz GJ: Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Am J Med 1986;80:98-104.
91. Lewin GR, Barde YA: Physiology of the neurotrophins. Annu Rev Neurosci 1996;19:289-317.
92. Li L, Forge A: Cultured explants of the vestibular sensory epithelia from adult guinea pigs and effects of gentamicin: A model for examination of hair cell loss and epithelial repair mechanisms. Aud Neurosci 1995;1:111-125.
93. Li L, Forge A, Nevill G: Apoptotic death of hair cells (abstract 445). Assoc Res Otolaryngol 1997;20.
94. Li L, Nevill G, Forge A: Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig. J Comp Neurol 1995;355:405-417.
95. Liberman MC, Dodds LW, Pierce S: Afferent and efferent innervation of the cat cochlea: Quantitative analysis with light and electron microscopy. J Comp Neurol 1990;301:443-460.
96. Lim D: Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. Am J Otolaryngol 1986;7:73-99.
97. Lin WS, Song XZ: Clinical and experimental research on a kidney-tonifying prescription in preventing and treating children's hearing loss induced by aminoglycoside antibiotic ototoxicity (in Chinese). Chin J Mod Devel Trad Med 1989;9:402-404.
98. Lindemann HH: Regional differences in sensitivity of the vestibular sensory epithelia to ototoxic antibiotics. Acta Otolaryngol 1969;67:177-189.
99. Lodhi S, Weiner ND, Mechigian I, Schacht J: Ototoxicity of aminoglycosides correlated with their action on monomolecular films of polyphosphoinositides. Biochem Pharmacol 1980; 29:597-601.
100. Low W, Dazert S, Baird A, Ryan AF: Basic fibroblast growth factor (FGF-2) protects rat cochlear hair cells in organotypical culture from aminoglycoside injury. J Cell Physiol 1996;167: 443-450.
101. Lu YF: Cause of 611 deaf mutes in schools for deaf children in Shanghai. Shanghai Med J 1987;10: 159.
102. Lyght ChE, Hawkins JE: Streptomycin and dihydrostreptomycin in the treatment of tuberculosis: A comparative study. Transactions 12th Conf on Chemother Tuberculosis. Washington, Veterans Administration, 1953, pp 125-133.
103. Marchionni MA, Grinspan JB, Canoll PD, Mahanthappa NK, Salzer JL, Scherer SS: Neuregulins as potential neuroprotective agents. Ann NY Acad Sci 1997;825:348-365.
104. Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E Jr, Murphy CA, Bartlett BA, Finn JP, Angeles T, Matsuda Y, Neff NT, Dionne CA: Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998; 18:104-111.
105. Marot M, Uziel A, Romand R: Ototoxicity of kanamycin in developing rats: Relationship with the onset of the auditory function. Hear Res 1980; 2:111-113.
106. Mathog RH, Klein WJ Jr: Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia. N Engl J Med 1969;280:1223-1224.
107. Meitles L, Raphael Y: Scar formation in the vestibular sensory epithelium after aminoglycoside toxicity. Hear Res 1994;79:26-38.
108. Mizuta K, Saito A, Watanabe T, Nagure M, Arakawa K, Shimizu F, Hishino T: Ultrastructural localization of megalin in the cochlear duct. Hear Res 1999;129:83-91.
109. Moestrup SK, Cui S, Vorum H, Bregengard C, Bjorn SE, Norris K, Gliemann J, Christensen EI: Evidence that epithelial glycoprotein 330/ megalin mediates uptake of polybasic drugs. J Clin Invest 1995;96:1404-1413.
110. Moore RD, Smith CR, Lietman PS: Risk factors for the development of auditory toxicity in patients receiving aminoglycosides. J Infect Dis 1984;149:23-30.
111. Mulheran M, Degg C: Comparison of distortion product OAE generation between a patient group requiring frequent gentamicin therapy and control subjects. BrJ Audiol 1997;31:5-9.
112. Mulherin D, Fahy J, Grant W, Keogan M, Kavanagh B, Fitzgerald M: Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Ir J Med Sci 1991;160:173-175.
113. Nadol JB Jr: Patterns of neural degeneration in the human cochlea and auditory nerve: Implications for cochlear implantation. Otolaryngol Head Neck Surg 1997;117:220-228.
114. Nakagawa T, Yamane H, Takayama M, Sunami K, Nakai Y: Apoptosis of guinea pig cochlear hair cells following aminoglycoside treatment. Eur Arch Otorhinolaryngol 1998;255:127-131.
115. Nakajima T, Hishida A, Kato A: Mechanisms for protective effects of free radical scavengers on gentamicin-mediated nephropathy in rats. Am J Physiol 1994;266:F425-F431.
116. Niwa Y, Miyachi Y: Antioxidant action of natural health products and Chinese herbs. Inflammation 1986;10:79-91.
117. Ohtsuki K, Ohtani I, Aikawa T, Sato Y, Anzai T, Ouchi J, Saito J: The ototoxicity and the accumulation in the inner ear fluids of the various aminoglycoside antibiotics. Ear Res Jpn 1982; 13:85-87.
118. Oppenheim RW: Related mechanisms of action of growth factors and antioxidants in apoptosis: An overview. Adv Neurol 1997;72:69-78.
119. Peterson CM, Graziano JH, Grady RW, Jones RL, Markenson A, Lavi U, Canale V, Gray GF, Cerami A, Miller DR: Chelation therapy in β-thalassemia major: A one-year double blind study of 2,3-dihydroxybenzoic acid. Exp Hematol 1979;7:74-80.
120. Pichler M, Wang Z, Grabner-Weiss C, Reimer D, Hering S, Grabner M, Glossmann H, Striessnig J: Block of P/Q-type calcium channels by therapeutic concentrations of aminoglycoside antibiotics. Biochemistry 1996;35:14659-14664.
121. Pierson MG, Møller AR: Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant. Hear Res 1981;4:79-87.
122. Pirvola U, Xing-Qun L, Aarnisalo AA, Saarma M, Walton KM, Ylikoski J: CEP-1347 (KT-7515) attenuates hair cell loss following traumas and promotes survival of cochlear neurons (abstract 895). Assoc Res Otolaryngol 1999;22.
123. Portmanm NM, Darriyzet HM, Ciste C: Distribution within the cochlea of dihydrostreptomycin injected into the circulation. Arch Otolaryngol 1974;100:473-475.
124. Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI: Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genetics 1993;4:289-294.
125. Prezant TR, Shohat M, Jaber L, Pressman S, Fischel-Ghodsian N: Biochemical characterization of a pedigree with mitochondrially inherited deafness. Am J Med Genet 1992;44:465-472.
126. Pritsos CA, Sartorelli AC: Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res 1986;46:3528-3532.
127. Priuska EM: The Mechanism of Free Radical Formation by Gentamicin: Implications for Ototoxicity; thesis University of Michigan, 1997.
128. Priuska EM, Clark K, Pecoraro V, Schacht J: NMR spectra of iron-gentamicin complexes and the implications for aminoglycoside toxicity. Inorg Chim Acta 1998;273:85-91.
129. Priuska EM, Schacht J: Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 1995;50:1749-1752.
130. Prosen CA, Petersen MR, Moody DB, Stebbins WC: Auditory thresholds and kanamycin-induced hearing loss in the guinea pig assessed by positive reinforcement procedures. J Acoust Soc Am 1978;63:559-566.
131. Puel JL, Pujol R, Tribillac F, Ladrech S, Eybalin M: Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity. J Comp Neurol 1994;341:241-256.
132. Pujol R: Periods of sensitivity to antibiotic treatment. Acta Otolaryngol Suppl (Stockh) 1986; 429:29-33.
133. Ramsammy LS, Josepovitz C, Ling K-Y, Lane BP, Kaloyanides GJ: Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat. Biochem Pharmacol 1987;36:2125-2132.
134. Ramsden RT, Wilson P, Gibson WP: Immediate effects of intravenous tobramycin and gentamicin on human cochlear function. J Laryngol Otol 1980;94:521-531.
135. Ramsey BW, Pepe MS, Quan JM, Otto KL, Montgomery AB, Williams-Warren J, Vasiljev-KM, Borowitz D, Bowman CM, Marshall BC, Marshall S, Smith AL: Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N Engl J Med 1999;340:23-30.
136. Raphael Y, Altschuler RA: Scar formation after drug-induced cochlear insult. Hear Res 1991; 51:173-184.
137. Raphael Y, Fein A, Nebel L: Transplacental kanamycin ototoxicity in the guinea pig. Arch Otorhinolaryngol 1983;238:45-51.
138. Raphael Y, Yagi M: Gene transfer and the inner ear. Curr Opin Otolaryngol Head Neck Surg 1998;6:311-315.
139. Rasmussen F: The ototoxic effect of streptomycin and dihydrostreptomycin on the foetus. Scand J Resp Dis 1969;50:61-67.
140. Richardson GP, Forge A, Kros CJ, Fleming J, Brown SDM, Steel KP: Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. J Neurosci 1997;17:9506-9519.
141. Richardson GP, Russell IJ: Cochlear culture as a model system for studying aminoglycoside-induced ototoxicity. Hear Res 1991;53:293-311.
142. Rüedi L, Furrer W, Graf K, Nager G, Tschirren B, Luthy F: Nouvelles constatations sur la toxicité de la streptomycine et de la quinine à l'égard de l'oreille du cobaye. Rev Laryngol (Bord) 1951; 72:238-264.
143. Rüedi L, Furrer W, Luthy F, Nager G, Tschirren B: Further observations concerning the toxic effects of streptomycin and quinine on the auditory organ of guinea pigs. Laryngoscope 1952; 62:333-357.
144. Sande MA, Mandell GL: Antimicrobial agents: The aminoglycosides; in Gilman AG, Rall TW, Nies AS, Taylor P (eds): The Pharmacological Basis of Therapeutics. New York, Pergamon Press, 1990, p 1102.
145. Satoh T, Enokido Y, Kubo T, Yamada M, Hatanaka H: Oxygen toxicity induces apoptosis in neuronal cells. Cell Mol Neurobiol 1998;18: 649-666.
146. Schacht J: Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney. Arch Otorhinolaryngol 1979;224:129-134.
147. Schatz A, Bugie E, Waksman SA: Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. Proc Soc Exp Biol Med 1944;55:66-69.
148. Shah SB, Gladstone HB, Williams H, Hradek GT, Schindler RA: An extended study: Protective effects of nerve growth factor in neomycin-induced auditory neural degeneration. Am J Otol 1995;16:310-314.
149. Sha S-H, Schacht J: Are aminoglycoside antibiotics excitotoxic? Neuroreport 1998;9:3893-3895.
150. Sha S-H, Schacht J: Formation of free radicals by aminoglycoside antibiotics. Hear Res 1999a; 128:112-118.
151. Sha S-H, Schacht J: Formation of reactive oxygen species following bioactivation of gentamicin. Free Radical Biol Med 1999b;26:341-347.
152. Sha S-H, Schacht J: Salicylate attenuates gentamicin-induced ototoxicity. Lab Invest 1999c;79: 807-813.
153. Sha S-H, Taylor R, Forge A, Schacht J: Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals (abstract 150). Assoc Res Otolaryngol 2000; 23.
154. Sha S-H, Zajic G, Schacht J: Transgenic mice overexpressing copper-zinc superoxide dismutase are protected from kanamycin-induced ototoxicity (abstract 122). Assoc Res Otolaryngol 1997;20.
155. Shafer RW, Goldberg R, Sierra M, Glatt AE: Frequency of Mycobacterium tuberculosis bacteremia in patients with tuberculosis in an area endemic for AIDS. Am Rev Respir Dis 1989; 140:1611-1613.
156. She W-D, Chen Z-H: Experimental study of antioxidation of ligustrazine on kanamycin ototoxicity. Proc Sendai Symp 1995;5:59-61.
157. Sone M, Schachern PA, Paparella MM: Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity. Hear Res 1998; 115:217-223.
158. Song B-B, Anderson DJ, Schacht J: Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo. J Pharmacol Exp Ther 1997; 282:369-377.
159. Song B-B, Schacht J: Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo. Hear Res 1996;94:87-93.
160. Song B-B, Sha S-H, Schacht J: Iron chelators protect from aminoglycoside-induced cochleo-and vestibulotoxicity in guinea pig. Free Radic Biol Med 1998;25:189-195.
161. Stebbins WC, McGinn CS, Feitosa MAG, Moody DB, Prosen CA, Serafin JV: Animal models in the study of ototoxic hearing loss; in Lerner SA, Matz GJ, Hawkins JE (eds): Aminoglycoside Ototoxicity. Boston, Little Brown, 1981, pp 5-25.
162. Stebbins WC, Miller JM, Johnsson L-G, Hawkins JE: Ototoxic hearing loss and cochlear pathology in the monkey. Ann Otol 1969;78:1007-1025.
163. Stratta P, Segoloni GP, Canavese C, Muzio G, Dogliani M, Serra A, Allemandi P, Salomone M, Caramellino C, Canuto R: Oxygen free radicals are not the main factor in experimental gentamicin ncphrotoxicity. Ren Fail 1994;16: 445-455.
164. Swan SK: Aminoglycoside nephrotoxicity. Semin Nephrol 1997;17:27-33.
165. Takada A, Schacht J: Calcium antagonism and reversibility of gentamicin-induced loss of cochlear microphonics in the guinea pig. Hear Res 1982;8:179-186.
166. Tan S, Sagara Y, Liu Y, Maher P, Schubert D: The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 1998;141:1423-1432.
167. Tanswell AK, Freeman BA: Antioxidant therapy in critical care medicine. New Horiz 1995;3:330-341.
168. Tong L, Toliver-Kinsky T, Taglialatela G, Werrbach-Perez K, Wood T, Perez-Polo R: Signal transduction in neuronal death. J Neurochem 1998;71:447-459.
169. Tran Ba Huy P, Bernard P, Schacht J: Kinetics of gentamicin uptake and release in the rat: Comparison of inner ear tissues and fluids with other organs. J Clin Invest 1986;77:1492-1500.
170. Usami S, Abe S, Tono T, Komune S, Kimberling WJ, Shinkawa H: Isepamicin sulfate-induced sensorineural hearing loss in patients with the 1555 A→G mitochondrial mutation. ORL 1998;60:164-169.
171. Usami S, Hjelle OP, Ottersen OP: Differential cellular distribution of glutathione - an endogenous amioxidant - in the guinea pig inner ear. Brain Res 1996;743:337-340.
172. Vital-Brazil O, Corrado AP: The curariform action of streptomycin. J Pharmacol Exp Ther 1957; 120:452-459.
173. Von Ilberg C, Spoendlin H, Arnold W: Autoradiographical distribution of locally applied dihydrostreptomycin in the inner ear. Acta Otolaryngol 1971;71:159-165.
174. Walker PD, Shah SV: Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 1987;253:C495-C499.
175. Walker PD, Shah SV: Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 1988;81:334-341.
176. Wang BM, Weiner ND, Takada A, Schacht J: Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing. Biochem Pharmacol 1984; 33:3257-3262.
177. Webster M, Webster DB: Spiral ganglion neuron loss following organ of Corti loss: A quantitative study. Brain Res 1981;212:17-30.
178. Wersäll J, Björkroth B, Flock A, Lundquist P-G: Experiments on ototoxic effects of antibiotics. Adv Otorhinolaryngol 1973;20:14-41.
179. Wersäll J, Flock Å: Suppression and restoration of the microphonic output from the lateral line organ after local application of streptomycin. Life Sci 1964;3:1151-1155.
180. Wersäll J, Lundquist P-G, Björkroth B: Ototoxicity of gentamicin. J Infect Dis 1969;119:410-416.
181. West BA, Brummet RE, Himes DL: Interaction of kanamycin and ethacrynic acid. Arch Otolaryngol 1973;98:32-37.
182. Williams SE, Smith DE, Schacht J: Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochem Pharmacol 1987;36:89-95.
183. Wong CH, Hendrix M, Priestley ES, Greenberg WA: Specificity of aminoglycoside antibiotics for the A-site of the decoding region of ribosomal RNA. Chem Biol 1998;5:397-406.
184. Wright T: Ototoxicity; in Ludman H, Wright T (eds): Diseases of the Ear, cd 6. London, Arnold, 1998, pp 502-515.
185. Xuan W, Dong M, Dong M: Effects of compound injection of Pyrola rotundifolia L and Astragalus membranaceus Bge on experimental guinea pigs' gentamicin ototoxicity. Ann Otol Rhinol Laryngol 1995;104:374-380.
186. Yagi M, Magal E, Sheng Z, Ang KA, Raphael Y: Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum Gene Ther 1999;10:813-823.
187. Yang CL, Du XH, Man YX: Renal cortical mitochondria are the source of oxygen free radicals enhanced by gentamicin. Ren Fail 1995;17:21-26.
188. Yin MJ, Yamamoto Y, Gaynor RB: The antiinflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998;396:77-80.
189. Ylikoski J, Pirvola U, Zhai S, Eriksson U, Solin M, Miettinen A: Aminoglycoside ototoxicity: High affinity receptors are expressed in secretory epithelia. Aud Neurosci 1997;3:415-424.
190. Zajic G, Schacht J: Immunocytochemical localization of megalin and alpha-2-macroglobulin within guinea pig cochlear tissues. Abstr Assoc Res Otolaryngol 1997;20:158.
191. Zappia JJ, Altschuler RA: Evaluation of the effect of ototopical neomycin on spiral ganglion cell density in the guinea pig. Hear Res 1989;40: 29-38.
192. Zheng JL, Gao WQ: Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures. Eur J Neurosci 1996;8:1897-1905.
193. Zheng JL, Stewart RR, Gao WQ: Neurotrophin-4/ 5, brain-derived neurotrophic factor, and neurotrophin-3 promote survival of cultured vestibular ganglion neurons and protect them against neurotoxicity of ototoxins. J Neurobiol 1995;28:330-440.