The molecular basis for A-site mutations conferring aminoglycoside resistance: Relationship between ribosomal susceptibility and X-ray crystal structures

ChemBioChem

Volumn 4, Issue 10, 2003, Pages 1078-1088

  Pfister, Peter ^a   Hobbie, Sven ^a   Vicens, Quentin ^b,c   Böttger, Erik C ^a   Westhof, Eric ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Aminoglycoside resistance; Antibiotics; Bacterial ribosomes; RNA; X ray crystal structures

Indexed keywords

ADENINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMMONIA; ANTIBIOTIC G 418; BACTERIAL RNA; CYTOSINE; GENTAMICIN; HYDROXYL GROUP; NEOMYCIN; OLIGONUCLEOTIDE; PAROMOMYCIN; RNA 16S; TOBRAMYCIN; URACIL;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BASE PAIRING; CRYSTAL STRUCTURE; DRUG STRUCTURE; GENETIC POLYMORPHISM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RIBOSOME; RNA A SITE; RNA STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE; ESCHERICHIA COLI; HEMAGGLUTININS; LECTINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PLASMIDS; POINT MUTATION; RIBOSOMES; RNA, BACTERIAL; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); INSERTION SEQUENCES;

EID: 0142075322     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300657     Document Type: Article

References (47)

1. E. F. Gale, E. Cundliffe, P. E. Reynolds, M. H. Richmond, M. J. Waring, The molecular basis of antibiotic action, 2nd ed., Wiley, London, 1981.
2. D. Moazed, H. F. Noller, Nature 1987, 327, 389-394.
3. T. Pape, W. Wintermeyer, M. V. Rodnina, Nat. Struct. Biol. 2000, 7, 104-107.
4. A. P. Carter, W. M. Clemons, D. E. Brodersen, R. J. Morgan-Warren, B. T. Wimberly, V. Ramakrishnan, Nature 2000, 407, 340-348.
5. J. M. Ogle, D. E. Brodersen, W. M. Clemons Jr., M. J. Tarry, A. P. Carter, V. Ramakrishnan, Science 2001, 292, 897-902.
6. J. M. Ogle, F. V. Murphy, M. J. Tarry, V. Ramakrishnan, Cell 2002, 111, 721-732.
7. a) B. D. Davis, L. L. Chen, P. C. Tai, Proc. Natl. Acad. Sci. USA 1986, 83, 6164-6168;
8. b) B. D. Davis, Microbiol. Rev. 1987, 51, 341-350.
9. F. Walter, Q. Vicens, E. Westhof, Curr. Opin. Chem. Biol. 1999, 3, 694-704.
10. G. D. Wright, A. M. Berghuis, S. Mobashery, Aminoglycoside Antibiotics. Structures, Functions, and Resistance in Resolving the Antibiotic Paradox: Progress in Understanding Drug Resistance and Development of New Antibiotics (Eds. B. P. Rosen, S. Mobashery), Plenum, New York, 1998, pp. 27-69.
11. D. E. Brodersen, W. M. Clemons Jr., A. P. Carter, R. J. Morgan-Warren, B. T. Wimberly, V. Ramakrishnan, Cell 2000, 103, 1143-1154.
12. Q. Vicens, E. Westhof, Structure 2001, 9, 647-658.
13. Q. Vicens, E. Westhof, Chem. Biol. 2002, 9, 747-755.
14. Q. Vicens, E. Westhof, J. Mol. Biol. 2003, 326, 1175-1188.
15. Q. Vicens, E. Westhof, Biopolymers 2003, 70, 42-57.
16. a) V. Ramakrishnan, Cell 2002, 108, 557-572;
17. b) V. Ramakrishnan, P. B. Moore, Curr. Opin. Struct. Biol. 2001, 11, 144-154.
18. P. Sander, T. Prammananan, E. C. Böttger, Mol. Microbiol. 1996, 22, 841-848.
19. M. I. Recht, J. D. Puglisi, Antimicrob. Agents Chemother. 2001, 45, 2414-2419.
20. M. I. Recht, S. Douthwaite, K. D. Dahlquist, J. D. Puglisi, J. Mol. Biol. 1999, 286, 33-43.
21. T. Prammananan, P. Sander, B. A. Brown, K. Frischkorn, G. O. Onyi, Y. Zhang, E. C. Böttger, R. J. Wallace Jr., J. Infect. Dis. 1998, 177, 1573-1581.
22. T. Asai, D. Zaporojets, C. Squires, C. L. Squires, Proc. Natl. Acad. Sci. USA 1999, 96, 1971-1976.
23. M. I. Recht, S. Douthwaite, J. D. Puglisi, EMBO J. 1999, 18, 3133-3138.
24. S. Yoshizawa, D. Fourmy, J. D. Puglisi, EMBO J. 1998, 17, 6437-6448.
25. L. P. Kotra, J. Haddad, S. Mobashery, Antimicrob. Agents Chemother. 2000, 44, 3249-3256.
26. E. DeStasio, D. Moazed, H. F. Noller, A. E. Dahlberg, EMBO J. 1989, 8, 1213-1216.
27. a) L. E. Wybenga-Groot, K. Draker, G. D. Wright, A. M. Berghuis, Structure Fold. Des. 1999, 7, 497-507;
28. b) J. Davies, G. D. Wright, Trends. Microbiol. 1997, 5, 234-240.
29. a) J. J. Cannone, S. Subramanian, M. N. Schnare, J. R. Collett, L. M. D'Souza, Y. Du, B. Feng, N. Lin, L. V Madabusi, K. M. Müller, N. Pande, Z. Shang, N. Yu, R. R. Gutell, BMC Bioinformatics 2002, 3, 2;
30. b) R. R. Gutell, Nucleic Acids Res. 1994, 22, 3502-3507.
31. J. G. Arnez, T. A. Steitz, Biochemistry 1996, 35, 14725-14733.
32. P. Auffinger, E. Westhof, J. Mol. Biol. 1999, 292, 467-483.
33. D. H. Ryu, R. R. Rando, Bioorg. Med. Chem. 2001, 9, 2601-2608.
34. M. Kaul, D. S. Pilch, Biochemistry 2002, 41, 7695-7706.
35. D. Fourmy, M. I. Recht, S. C. Blanchard, J. D. Puglisi, Science 1996, 274, 1367-1371.
36. J. Sambrook, E. F. Fischer, T. Maniatis, Molecular Cloning. A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989.
37. D. J. Lydiate, A. M. Ashby, D. J. Henderson, H. M. Kieser, D. A. Hopwood, J. Gen. Microbiol. 1989, 135, 941-955.
38. P. Sander, A. Meier, E. C. Böttger, Mol. Microbiol. 1995, 16, 991-1000.
39. P. Sander, B. Springer, E. C. Böttger, Gene Replacement in Mycobacterium tuberculosis and Mycobacterium bovis BCG using rpsL + as a Dominant Negative Selectable Marker in Mycobacterium tuberculosis Protocols, (Eds.: T. Parish, N.G. Stoker,), Humana Press, Totowa, New Jersey, 2001, pp. 93-104.
40. P. Pfister, M. Risch, D. E. Brodersen, E. C. Böttger, Antimicrob. Agents Chemother. 2003, 47, 1496-1502.
41. T. Prammananan, P. Sander, B. Springer, E. C. Böttger, Antimicrob. Agents Chemother. 1999, 43, 447-453.
42. P. Sander, T. Prammananan, A. Meier, K. Fischkorn, E. C. Böttger, Mol. Microbiol. 1997, 26, 469-480.
43. B. Masquida, C. Sauter, E. Westhof, RNA 1999, 5, 1384-1395.
44. G. J. Kleywegt, Acta Cryst. 1996, D52, 842-857.
45. C. Massire. Ph.D. thesis, Université Louis Pasteur de Strasbourg, France, 1998.
46. a) J. R. Cole, B. Chai, T. L. Marsh, R. J. Farris, Q. Wang, S. A. Kulam, S. Chandra, D. M. McGarrell, T. M. Schmidt, G. M. Garrity, J. M. Tiedje, Nucleic Acids Res. 2003, 31, 442-443;
47. b) http://rdp.cme.msu.edu.