Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity

Journal of the American Chemical Society

Volumn 128, Issue 4, 2006, Pages 1261-1271

  Kaul, Malvika ^a   Barbieri, Christopher M ^a   Pilch, Daniel S ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CONFORMATIONS; DRUG INTERACTIONS; FLUORESCENCE; PROTEINS; RNA;

AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTICS; ANTIBACTERIAL ACTIVITY; CONFORMATIONAL EQUILIBRIUM;

NUCLEIC ACIDS;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC G 418; MESSENGER RNA; NEOMYCIN; PAROMOMYCIN; RIBOSOME RNA; RIBOSTAMYCIN; RNA 16S; TRANSFER RNA;

ANISOTROPY; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BINDING AFFINITY; DRUG TARGETING; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; NONHUMAN; STEADY STATE; TIME;

2-AMINOPURINE; ADENINE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOHYDRATE SEQUENCE; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; PAROMOMYCIN; RIBOSTAMYCIN; RNA, RIBOSOMAL, 16S; SPECTROMETRY, FLUORESCENCE;

EID: 31944443056     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja056159z     Document Type: Article

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