메뉴 건너뛰기




Volumn 12, Issue 1, 2014, Pages 111-125

Investigational drugs targeting cardiac fibrosis

Author keywords

cardiac fibrosis; collagen; extracellular matrix; heart failure; hypertrophy; myocardium; myofibroblast; remodeling; TGF

Indexed keywords

AMLODIPINE; ANTIINFLAMMATORY AGENT; CARDIOVASCULAR AGENT; IVABRADINE; LISINOPRIL; LOSARTAN; OLMESARTAN;

EID: 84893103006     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2013.839942     Document Type: Review
Times cited : (56)

References (133)
  • 1
    • 0028154103 scopus 로고
    • Structural basis of end-stage failure in ischemic cardiomyopathy in humans
    • Beltrami CA, Finato N, Rocco M et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89(1), 151-163 (1994).
    • (1994) Circulation , vol.89 , Issue.1 , pp. 151-163
    • Beltrami, C.A.1    Finato, N.2    Rocco, M.3
  • 2
    • 0028911936 scopus 로고
    • Increased serum concentrations of procollagen peptides in essential hypertension. Relation to cardiac alterations
    • Diez J, Laviades C, Mayor G, Gil MJ, Monreal I. Increased serum concentrations of procollagen peptides in essential hypertension. Relation to cardiac alterations. Circulation 91(5), 1450-1456 (1995).
    • (1995) Circulation , vol.91 , Issue.5 , pp. 1450-1456
    • Diez, J.1    Laviades, C.2    Mayor, G.3    Gil, M.J.4    Monreal, I.5
  • 3
    • 0035100731 scopus 로고    scopus 로고
    • Regulation of cardiac collagen: Angiotensin and cross-talk with local growth factors
    • Dostal DE. Regulation of cardiac collagen: Angiotensin and cross-talk with local growth factors. Hypertension 37(3), 841-844 (2001).
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 841-844
    • Dostal, D.E.1
  • 4
    • 0025122007 scopus 로고
    • Diastolic dysfunction and congestive heart failure
    • Grossman W. Diastolic dysfunction and congestive heart failure. Circulation 81(2 Suppl.), III1-III7 (1990).
    • (1990) Circulation , vol.81 , Issue.2 SUPPL.
    • Grossman, W.1
  • 5
    • 84860228275 scopus 로고    scopus 로고
    • Myocardial delayed enhancement in paucisymptomatic nonischemic dilated cardiomyopathy
    • Masci PG, Barison A, Aquaro GD et al. Myocardial delayed enhancement in paucisymptomatic nonischemic dilated cardiomyopathy. Int. J. Cardiol. 157(1), 43-47 (2012).
    • (2012) Int. J. Cardiol. , vol.157 , Issue.1 , pp. 43-47
    • Masci, P.G.1    Barison, A.2    Aquaro, G.D.3
  • 6
    • 0028969496 scopus 로고
    • Dilated cardiomyopathy is associated with an increase in the type I/ type III collagen ratio: A quantitative assessment
    • Marijianowski MM, Teeling P, Mann J, Becker AE. Dilated cardiomyopathy is associated with an increase in the type I/ type III collagen ratio: a quantitative assessment. J. Am. Coll. Cardiol. 25(6), 1263-1272 (1995).
    • (1995) J. Am. Coll. Cardiol. , vol.25 , Issue.6 , pp. 1263-1272
    • Marijianowski, M.M.1    Teeling, P.2    Mann, J.3    Becker, A.E.4
  • 7
    • 69449089001 scopus 로고    scopus 로고
    • Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: Correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system
    • Blauwet LA, Ackerman MJ, Edwards WD, Riehle DL, Ommen SR. Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system. Cardiovasc. Pathol. 18(5), 262-268 (2009).
    • (2009) Cardiovasc. Pathol. , vol.18 , Issue.5 , pp. 262-268
    • Blauwet, L.A.1    Ackerman, M.J.2    Edwards, W.D.3    Riehle, D.L.4    Ommen, S.R.5
  • 8
    • 0025893212 scopus 로고
    • Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy
    • Factor SM, Butany J, Sole MJ, Wigle ED, Williams WC, Rojkind M. Pathologic fibrosis and matrix connective tissue in the subaortic myocardium of patients with hypertrophic cardiomyopathy. J. Am. Coll. Cardiol. 17(6), 1343-1351 (1991).
    • (1991) J. Am. Coll. Cardiol. , vol.17 , Issue.6 , pp. 1343-1351
    • Factor, S.M.1    Butany, J.2    Sole, M.J.3    Wigle, E.D.4    Williams, W.C.5    Rojkind, M.6
  • 9
    • 0024410697 scopus 로고
    • Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
    • Jalil JE, Doering CW, Janicki JS, Pick R, Shroff SG, Weber KT. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ. Res. 64(6), 1041-1050 (1989).
    • (1989) Circ. Res. , vol.64 , Issue.6 , pp. 1041-1050
    • Jalil, J.E.1    Doering, C.W.2    Janicki, J.S.3    Pick, R.4    Shroff, S.G.5    Weber, K.T.6
  • 10
    • 0034687149 scopus 로고    scopus 로고
    • Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
    • Brilla CG, Funck RC, Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation 102(12), 1388-1393 (2000).
    • (2000) Circulation , vol.102 , Issue.12 , pp. 1388-1393
    • Brilla, C.G.1    Funck, R.C.2    Rupp, H.3
  • 11
    • 85028118511 scopus 로고    scopus 로고
    • Atrial fibrillation and atrial fibrosis
    • Tan AY, Zimetbaum P. Atrial fibrillation and atrial fibrosis. J. Cardiovasc. Pharmacol. 57(6), 625-629 (2011).
    • (2011) J. Cardiovasc. Pharmacol. , vol.57 , Issue.6 , pp. 625-629
    • Tan, A.Y.1    Zimetbaum, P.2
  • 12
    • 34547676391 scopus 로고    scopus 로고
    • Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
    • Zeisberg EM, Tarnavski O, Zeisberg M et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13(8), 952-961 (2007).
    • (2007) Nat. Med. , vol.13 , Issue.8 , pp. 952-961
    • Zeisberg, E.M.1    Tarnavski, O.2    Zeisberg, M.3
  • 13
    • 84856259347 scopus 로고    scopus 로고
    • Targeting fibrosis for the treatment of heart failure: A role for transforming growth factor-beta
    • Edgley AJ, Krum H, Kelly DJ. Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta. Cardiovasc. Ther. 30(1), e30-40 (2012).
    • (2012) Cardiovasc. Ther. , vol.30 , Issue.1
    • Edgley, A.J.1    Krum, H.2    Kelly, D.J.3
  • 15
    • 84859073207 scopus 로고    scopus 로고
    • Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling
    • Hinz B, Phan SH, Thannickal VJ et al. Recent developments in myofibroblast biology: Paradigms for connective tissue remodeling. Am. J. Pathol. 180(4), 1340-1355 (2012).
    • (2012) Am. J. Pathol. , vol.180 , Issue.4 , pp. 1340-1355
    • Hinz, B.1    Phan, S.H.2    Thannickal, V.J.3
  • 16
    • 27744606970 scopus 로고    scopus 로고
    • Sparc regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
    • Barker TH, Baneyx G, Cardo-Vila M et al. Sparc regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. J. Biol. Chem. 280(43), 36483-36493 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.43 , pp. 36483-36493
    • Barker, T.H.1    Baneyx, G.2    Cardo-Vila, M.3
  • 17
    • 84866900231 scopus 로고    scopus 로고
    • Matrix control of transforming growth factor-beta function
    • Horiguchi M, Ota M, Rifkin DB. Matrix control of transforming growth factor-beta function. J. Biochem. 152(4), 321-329 (2012).
    • (2012) J. Biochem. , vol.152 , Issue.4 , pp. 321-329
    • Horiguchi, M.1    Ota, M.2    Rifkin, D.B.3
  • 19
    • 84859469406 scopus 로고    scopus 로고
    • Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of tgf-beta signaling
    • Wei H, Bedja D, Koitabashi N et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of tgf-beta signaling. Proc. Natl Acad. Sci. USA 109(14), E841-850 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.14
    • Wei, H.1    Bedja, D.2    Koitabashi, N.3
  • 20
    • 84886056529 scopus 로고    scopus 로고
    • Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis
    • doi:10.1093/cvr/cvt181 Epub ahead of print
    • Kazakov A, Hall R, Jagoda P et al. Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis. Cardiovasc. Res. doi:10.1093/cvr/ cvt181 (2013) (Epub ahead of print).
    • (2013) Cardiovasc. Res.
    • Kazakov, A.1    Hall, R.2    Jagoda, P.3
  • 21
    • 77954879762 scopus 로고    scopus 로고
    • Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor
    • Kanellakis P, Pomilio G, Agrotis A et al. Darbepoetin-mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor-common beta-chain heteroreceptor. Br. J. Pharmacol. 160(8), 2085-2096 (2010).
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.8 , pp. 2085-2096
    • Kanellakis, P.1    Pomilio, G.2    Agrotis, A.3
  • 22
    • 58149401216 scopus 로고    scopus 로고
    • Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension
    • Sun Y, Carretero OA, Xu J et al. Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension. Hypertension 53(1), 49-56 (2009).
    • (2009) Hypertension , vol.53 , Issue.1 , pp. 49-56
    • Sun, Y.1    Carretero, O.A.2    Xu, J.3
  • 23
    • 84879763603 scopus 로고    scopus 로고
    • Pirfenidone attenuates cardiac fibrosis in a mouse model of tac-induced left ventricular remodeling by suppressing nlrp3 inflammasome formation
    • Wang Y, Wu Y, Chen J, Zhao S, Li H. Pirfenidone attenuates cardiac fibrosis in a mouse model of tac-induced left ventricular remodeling by suppressing nlrp3 inflammasome formation. Cardiology 126(1), 1-11 (2013).
    • (2013) Cardiology , vol.126 , Issue.1 , pp. 1-11
    • Wang, Y.1    Wu, Y.2    Chen, J.3    Zhao, S.4    Li, H.5
  • 24
    • 34548414571 scopus 로고    scopus 로고
    • Myocardial fibrosis and diastolic dysfunction in patients with hypertension: Results from the swedish irbesartan left ventricular hypertrophy investigation versus atenolol (silvhia)
    • Muller-Brunotte R, Kahan T, Lopez B et al. Myocardial fibrosis and diastolic dysfunction in patients with hypertension: Results from the swedish irbesartan left ventricular hypertrophy investigation versus atenolol (silvhia). J. Hypertens. 25(9), 1958-1966 (2007).
    • (2007) J. Hypertens. , vol.25 , Issue.9 , pp. 1958-1966
    • Muller-Brunotte, R.1    Kahan, T.2    Lopez, B.3
  • 25
    • 0032508355 scopus 로고    scopus 로고
    • Abnormalities of the extracellular degradation of collagen type i in essential hypertension
    • Laviades C, Varo N, Fernandez J et al. Abnormalities of the extracellular degradation of collagen type I in essential hypertension. Circulation 98(6), 535-540 (1998).
    • (1998) Circulation , vol.98 , Issue.6 , pp. 535-540
    • Laviades, C.1    Varo, N.2    Fernandez, J.3
  • 26
    • 0025770664 scopus 로고
    • Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system
    • Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83(6), 1849-1865 (1991).
    • (1991) Circulation , vol.83 , Issue.6 , pp. 1849-1865
    • Weber, K.T.1    Brilla, C.G.2
  • 27
    • 0027417926 scopus 로고
    • Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type i collagen: A new serum marker of bone collagen degradation
    • Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L. Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: A new serum marker of bone collagen degradation. Clin. Chem. 39(4), 635-640 (1993).
    • (1993) Clin. Chem. , vol.39 , Issue.4 , pp. 635-640
    • Risteli, J.1    Elomaa, I.2    Niemi, S.3    Novamo, A.4    Risteli, L.5
  • 28
    • 84896717485 scopus 로고    scopus 로고
    • Fibrosis and heart failure
    • doi:10.1007/s10741-012-9365-4 Epub ahead of print
    • Segura AM, Frazier OH, Buja LM. Fibrosis and heart failure. Heart Fail. Rev. doi:10.1007/s10741-012-9365-4 (2012) (Epub ahead of print).
    • (2012) Heart Fail. Rev.
    • Segura, A.M.1    Frazier, O.H.2    Buja, L.M.3
  • 29
    • 41949090461 scopus 로고    scopus 로고
    • The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance
    • Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J. Am. Coll. Cardiol. 51(16), 1581-1587 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.51 , Issue.16 , pp. 1581-1587
    • Friedrich, M.G.1    Abdel-Aty, H.2    Taylor, A.3    Schulz-Menger, J.4    Messroghli, D.5    Dietz, R.6
  • 30
    • 84862838262 scopus 로고    scopus 로고
    • Patterns of myocardial late enhancement: Typical and atypical features
    • Vermes E, Carbone I, Friedrich MG, Merchant N. Patterns of myocardial late enhancement: typical and atypical features. Arch. Cardiovasc. Dis. 105(5), 300-308 (2012).
    • (2012) Arch. Cardiovasc. Dis. , vol.105 , Issue.5 , pp. 300-308
    • Vermes, E.1    Carbone, I.2    Friedrich, M.G.3    Merchant, N.4
  • 31
    • 76949091225 scopus 로고    scopus 로고
    • Mr delayed enhancement imaging findings in suspected acute myocarditis
    • Gahide G, Bertrand D, Roubille F et al. Mr delayed enhancement imaging findings in suspected acute myocarditis. Eur. Radiol. 20(1), 65-72 (2010).
    • (2010) Eur. Radiol. , vol.20 , Issue.1 , pp. 65-72
    • Gahide, G.1    Bertrand, D.2    Roubille, F.3
  • 32
    • 77649236384 scopus 로고    scopus 로고
    • Can troponin elevation predict worse prognosis in patients with acute pericarditis?
    • Machado S, Roubille F, Gahide G et al. Can troponin elevation predict worse prognosis in patients with acute pericarditis? Ann. Cardiol. Angeiol. (Paris) 59(1), 1-7 (2010).
    • (2010) Ann. Cardiol. Angeiol. (Paris) , vol.59 , Issue.1 , pp. 1-7
    • Machado, S.1    Roubille, F.2    Gahide, G.3
  • 34
    • 34547791476 scopus 로고    scopus 로고
    • Myocardial T1 mapping: Application to patients with acute and chronic myocardial infarction
    • Messroghli DR, Walters K, Plein S et al. Myocardial T1 mapping: Application to patients with acute and chronic myocardial infarction. Magn. Reson. Med. 58(1), 34-40 (2007).
    • (2007) Magn. Reson. Med. , vol.58 , Issue.1 , pp. 34-40
    • Messroghli, D.R.1    Walters, K.2    Plein, S.3
  • 35
    • 79951642225 scopus 로고    scopus 로고
    • Assessment of myocardial fibrosis with cardiovascular magnetic resonance
    • Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J. Am. Coll. Cardiol. 57(8), 891-903 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.57 , Issue.8 , pp. 891-903
    • Mewton, N.1    Liu, C.Y.2    Croisille, P.3    Bluemke, D.4    Lima, J.A.5
  • 36
    • 54349098686 scopus 로고    scopus 로고
    • Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping
    • Iles L, Pfluger H, Phrommintikul A et al. Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. J. Am. Coll. Cardiol. 52(19), 1574-1580 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.19 , pp. 1574-1580
    • Iles, L.1    Pfluger, H.2    Phrommintikul, A.3
  • 37
    • 84863649573 scopus 로고    scopus 로고
    • T1 mapping shows increased extracellular matrix size in the myocardium due to amyloid depositions
    • Robbers LF, Baars EN, Brouwer WP et al. T1 mapping shows increased extracellular matrix size in the myocardium due to amyloid depositions. Circ. Cardiovasc. Imaging 5(3), 423-426 (2012).
    • (2012) Circ. Cardiovasc. Imaging , vol.5 , Issue.3 , pp. 423-426
    • Robbers, L.F.1    Baars, E.N.2    Brouwer, W.P.3
  • 38
    • 54049149859 scopus 로고    scopus 로고
    • Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy
    • Jerosch-Herold M, Sheridan DC, Kushner JD et al. Cardiac magnetic resonance imaging of myocardial contrast uptake and blood flow in patients affected with idiopathic or familial dilated cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 295(3), H1234-H1242 (2008).
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295 , Issue.3
    • Jerosch-Herold, M.1    Sheridan, D.C.2    Kushner, J.D.3
  • 39
    • 84860917690 scopus 로고    scopus 로고
    • Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    • Ugander M, Oki AJ, Hsu LY et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur. Heart J. 33(10), 1268-1278 (2012).
    • (2012) Eur. Heart J. , vol.33 , Issue.10 , pp. 1268-1278
    • Ugander, M.1    Oki, A.J.2    Hsu, L.Y.3
  • 40
    • 84865863380 scopus 로고    scopus 로고
    • Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality
    • Wong TC, Piehler K, Meier CG et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 126(10), 1206-1216 (2012).
    • (2012) Circulation , vol.126 , Issue.10 , pp. 1206-1216
    • Wong, T.C.1    Piehler, K.2    Meier, C.G.3
  • 41
    • 84872914836 scopus 로고    scopus 로고
    • Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: Sample size considerations for clinical trials
    • Liu S, Han J, Nacif MS et al. Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials. J. Cardiovasc. Magn. Reson. 14, 90 (2012).
    • (2012) J. Cardiovasc. Magn. Reson. , vol.14 , pp. 90
    • Liu, S.1    Han, J.2    Nacif, M.S.3
  • 42
    • 84862489811 scopus 로고    scopus 로고
    • Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: A comparison to T2-weighted cardiovascular magnetic resonance
    • Ferreira VM, Piechnik SK, Dall'Armellina E et al. Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 14, 42 (2012).
    • (2012) J. Cardiovasc. Magn. Reson. , vol.14 , pp. 42
    • Ferreira, V.M.1    Piechnik, S.K.2    Dall'Armellina, E.3
  • 43
    • 67650077678 scopus 로고    scopus 로고
    • Mr elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure-volume model in a left ventricular model of the heart
    • Kolipaka A, McGee KP, Araoz PA et al. Mr elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure-volume model in a left ventricular model of the heart. Magn. Reson. Med. 62(1), 135-140 (2009).
    • (2009) Magn. Reson. Med. , vol.62 , Issue.1 , pp. 135-140
    • Kolipaka, A.1    McGee, K.P.2    Araoz, P.A.3
  • 45
    • 62649114456 scopus 로고    scopus 로고
    • Mr elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations
    • Sack I, Rump J, Elgeti T, Samani A, Braun J. Mr elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations. Magn. Reson. Med. 61(3), 668-677 (2009).
    • (2009) Magn. Reson. Med. , vol.61 , Issue.3 , pp. 668-677
    • Sack, I.1    Rump, J.2    Elgeti, T.3    Samani, A.4    Braun, J.5
  • 47
    • 84865849112 scopus 로고    scopus 로고
    • Transthyretin (TTR) cardiac amyloidosis
    • Ruberg FL, Berk JL. Transthyretin (TTR) cardiac amyloidosis. Circulation 126(10), 1286-1300 (2012).
    • (2012) Circulation , vol.126 , Issue.10 , pp. 1286-1300
    • Ruberg, F.L.1    Berk, J.L.2
  • 48
    • 64649106481 scopus 로고    scopus 로고
    • Cardiovascular magnetic resonance in myocarditis: A JACC white paper
    • Friedrich MG, Sechtem U, Schulz-Menger J et al. Cardiovascular magnetic resonance in myocarditis: A JACC white paper. J. Am. Coll. Cardiol. 53(17), 1475-1487 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , Issue.17 , pp. 1475-1487
    • Friedrich, M.G.1    Sechtem, U.2    Schulz-Menger, J.3
  • 49
    • 33644555227 scopus 로고    scopus 로고
    • Patterns of myocardial inflammation and scarring in sarcoidosis as assessed by cardiovascular magnetic resonance
    • Schulz-Menger J, Wassmuth R, Abdel-Aty H et al. Patterns of myocardial inflammation and scarring in sarcoidosis as assessed by cardiovascular magnetic resonance. Heart 92(3), 399-400 (2006).
    • (2006) Heart , vol.92 , Issue.3 , pp. 399-400
    • Schulz-Menger, J.1    Wassmuth, R.2    Abdel-Aty, H.3
  • 50
    • 84876293435 scopus 로고    scopus 로고
    • Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis
    • Won S, Davies-Venn C, Liu S, Bluemke DA. Noninvasive imaging of myocardial extracellular matrix for assessment of fibrosis. Curr. Opin. Cardiol. 28(3), 282-289 (2013).
    • (2013) Curr. Opin. Cardiol. , vol.28 , Issue.3 , pp. 282-289
    • Won, S.1    Davies-Venn, C.2    Liu, S.3    Bluemke, D.A.4
  • 51
    • 0034032577 scopus 로고    scopus 로고
    • Regression of myocardial fibrosis in hypertensive heart disease: Diverse effects of various antihypertensive drugs
    • Brilla CG. Regression of myocardial fibrosis in hypertensive heart disease: Diverse effects of various antihypertensive drugs. Cardiovasc. Res. 46(2), 324-331 (2000).
    • (2000) Cardiovasc. Res. , vol.46 , Issue.2 , pp. 324-331
    • Brilla, C.G.1
  • 52
    • 0035902457 scopus 로고    scopus 로고
    • Usefulness of serum carboxy-terminal propeptide of procollagen type i in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients
    • Lopez B, Querejeta R, Varo N et al. Usefulness of serum carboxy-terminal propeptide of procollagen type I in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients. Circulation 104(3), 286-291 (2001).
    • (2001) Circulation , vol.104 , Issue.3 , pp. 286-291
    • Lopez, B.1    Querejeta, R.2    Varo, N.3
  • 53
    • 80052821710 scopus 로고    scopus 로고
    • Targeting the ace2-ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure
    • Iwata M, Cowling RT, Yeo SJ, Greenberg B. Targeting the ace2-ang-(1-7) pathway in cardiac fibroblasts to treat cardiac remodeling and heart failure. J.Mol. Cell. Cardiol. 51(4), 542-547 (2011).
    • (2011) J.Mol. Cell. Cardiol. , vol.51 , Issue.4 , pp. 542-547
    • Iwata, M.1    Cowling, R.T.2    Yeo, S.J.3    Greenberg, B.4
  • 54
    • 0036099831 scopus 로고    scopus 로고
    • Angiotensin II as a cardiovascular risk factor
    • Gavras I, Gavras H. Angiotensin II as a cardiovascular risk factor. J. Hum. hypertens. 16(Suppl. 2), S2-6 (2002).
    • (2002) J. Hum. Hypertens. , vol.16 , Issue.SUPPL. 2
    • Gavras, I.1    Gavras, H.2
  • 55
    • 28144432331 scopus 로고    scopus 로고
    • Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects
    • Iwata M, Cowling RT, Gurantz D et al. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am. J. Physiol. Heart Circ. Physiol. 289(6), H2356-2363 (2005).
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , Issue.6
    • Iwata, M.1    Cowling, R.T.2    Gurantz, D.3
  • 56
    • 84873457180 scopus 로고    scopus 로고
    • TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis
    • Duerrschmid C, Crawford JR, Reineke E et al. TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. J. Mol. Cell. Cardiol. 57, 59-67 (2013).
    • (2013) J. Mol. Cell. Cardiol. , vol.57 , pp. 59-67
    • Duerrschmid, C.1    Crawford, J.R.2    Reineke, E.3
  • 57
    • 84875477901 scopus 로고    scopus 로고
    • Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice
    • Nakagami F, Koriyama H, Nakagami H et al. Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice. PLoS ONE 8(3), e60493 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.3
    • Nakagami, F.1    Koriyama, H.2    Nakagami, H.3
  • 58
    • 0029774377 scopus 로고    scopus 로고
    • Advanced hypertensive heart disease in spontaneously hypertensive rats. Lisinopril-mediated regression of myocardial fibrosis
    • Brilla CG, Matsubara L, Weber KT. Advanced hypertensive heart disease in spontaneously hypertensive rats. Lisinopril-mediated regression of myocardial fibrosis. Hypertension 28(2), 269-275 (1996).
    • (1996) Hypertension , vol.28 , Issue.2 , pp. 269-275
    • Brilla, C.G.1    Matsubara, L.2    Weber, K.T.3
  • 59
    • 0028261960 scopus 로고
    • Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat
    • Schieffer B, Wirger A, Meybrunn M et al. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation 89(5), 2273-2282 (1994).
    • (1994) Circulation , vol.89 , Issue.5 , pp. 2273-2282
    • Schieffer, B.1    Wirger, A.2    Meybrunn, M.3
  • 60
    • 33749826834 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction
    • Matsusaka H, Kinugawa S, Ide T et al. Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction. J. Cardiovasc. Pharmacol. 48(3), 95-102 (2006).
    • (2006) J. Cardiovasc. Pharmacol. , vol.48 , Issue.3 , pp. 95-102
    • Matsusaka, H.1    Kinugawa, S.2    Ide, T.3
  • 61
    • 77952983248 scopus 로고    scopus 로고
    • Candesartan decreases type III procollagen-n-peptide levels and inflammatory marker levels and maintains sinus rhythm in patients with atrial fibrillation
    • Kawamura M, Ito H, Onuki T et al. Candesartan decreases type III procollagen-n-peptide levels and inflammatory marker levels and maintains sinus rhythm in patients with atrial fibrillation. J. Cardiovasc. Pharmacol. 55(5), 511-517 (2010).
    • (2010) J. Cardiovasc. Pharmacol. , vol.55 , Issue.5 , pp. 511-517
    • Kawamura, M.1    Ito, H.2    Onuki, T.3
  • 62
    • 79751504524 scopus 로고    scopus 로고
    • Ace2-angiotensin-(1-7)-mas axis and oxidative stress in cardiovascular disease
    • Rabelo LA, Alenina N, Bader M. Ace2-angiotensin-(1-7)-mas axis and oxidative stress in cardiovascular disease. Hypertens. Res. 34(2), 154-160 (2011).
    • (2011) Hypertens. Res. , vol.34 , Issue.2 , pp. 154-160
    • Rabelo, L.A.1    Alenina, N.2    Bader, M.3
  • 63
    • 33846256550 scopus 로고    scopus 로고
    • Ace2 of the heart: From angiotensin i to angiotensin (1-7)
    • Keidar S, Kaplan M, Gamliel-Lazarovich A. Ace2 of the heart: From angiotensin i to angiotensin (1-7). Cardiovasc. Res. 73(3), 463-469 (2007).
    • (2007) Cardiovasc. Res. , vol.73 , Issue.3 , pp. 463-469
    • Keidar, S.1    Kaplan, M.2    Gamliel-Lazarovich, A.3
  • 64
    • 34548822986 scopus 로고    scopus 로고
    • Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in dahl salt-sensitive hypertensive rats
    • Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M. Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in dahl salt-sensitive hypertensive rats. Am. J. Hypertens. 20(10), 1119-1124 (2007).
    • (2007) Am. J. Hypertens. , vol.20 , Issue.10 , pp. 1119-1124
    • Takeda, Y.1    Zhu, A.2    Yoneda, T.3    Usukura, M.4    Takata, H.5    Yamagishi, M.6
  • 65
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme exacerbates cardiac hypertrophy and fibrosis in ren-2 hypertensive rats
    • Trask AJ, Groban L, Westwood BM et al. Inhibition of angiotensin- converting enzyme exacerbates cardiac hypertrophy and fibrosis in ren-2 hypertensive rats. Am. J. Hypertens. 23(6), 687-693 (2010).
    • (2010) Am. J. Hypertens. , vol.23 , Issue.6 , pp. 687-693
    • Trask, A.J.1    Groban, L.2    Westwood, B.M.3
  • 66
    • 84863116259 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy
    • Dong B, Yu QT, Dai HY et al. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J. Am. Coll. Cardiol. 59(8), 739-747 (2012).
    • (2012) J. Am. Coll. Cardiol. , vol.59 , Issue.8 , pp. 739-747
    • Dong, B.1    Yu, Q.T.2    Dai, H.Y.3
  • 67
    • 84861531444 scopus 로고    scopus 로고
    • Aldosterone inhibits antifibrotic factors in mouse hypertensive heart
    • Azibani F, Benard L, Schlossarek S et al. Aldosterone inhibits antifibrotic factors in mouse hypertensive heart. Hypertension 59(6), 1179-1187 (2012).
    • (2012) Hypertension , vol.59 , Issue.6 , pp. 1179-1187
    • Azibani, F.1    Benard, L.2    Schlossarek, S.3
  • 68
    • 84861614304 scopus 로고    scopus 로고
    • Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice
    • Azibani F, Devaux Y, Coutance G et al. Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice. PloS ONE 7(5), e38197 (2012).
    • (2012) PloS ONE , vol.7 , Issue.5
    • Azibani, F.1    Devaux, Y.2    Coutance, G.3
  • 69
    • 83455172574 scopus 로고    scopus 로고
    • A randomized study of the beneficial effects of aldosterone antagonism on lv function, structure, and fibrosis markers in metabolic syndrome
    • Kosmala W, Przewlocka-Kosmala M, Szczepanik-Osadnik H, Mysiak A, O'Moore-Sullivan T, Marwick TH. A randomized study of the beneficial effects of aldosterone antagonism on lv function, structure, and fibrosis markers in metabolic syndrome. JACC Cardiovasc. Imaging 4(12), 1239-1249 (2011).
    • (2011) JACC Cardiovasc. Imaging , vol.4 , Issue.12 , pp. 1239-1249
    • Kosmala, W.1    Przewlocka-Kosmala, M.2    Szczepanik-Osadnik, H.3    Mysiak, A.4    O'Moore-Sullivan, T.5    Marwick, T.H.6
  • 70
    • 84874105560 scopus 로고    scopus 로고
    • Fibrosis and cardiac function in obesity: A randomised controlled trial of aldosterone blockade
    • Kosmala W, Przewlocka-Kosmala M, Szczepanik-Osadnik H, Mysiak A, Marwick TH. Fibrosis and cardiac function in obesity: A randomised controlled trial of aldosterone blockade. Heart 99(5), 320-326 (2013).
    • (2013) Heart , vol.99 , Issue.5 , pp. 320-326
    • Kosmala, W.1    Przewlocka-Kosmala, M.2    Szczepanik-Osadnik, H.3    Mysiak, A.4    Marwick, T.H.5
  • 71
    • 70349990209 scopus 로고    scopus 로고
    • Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone
    • Mak GJ, Ledwidge MT, Watson CJ et al. Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. J. Am. Coll. Cardiol. 54(18), 1674-1682 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.54 , Issue.18 , pp. 1674-1682
    • Mak, G.J.1    Ledwidge, M.T.2    Watson, C.J.3
  • 72
    • 84877918970 scopus 로고    scopus 로고
    • New therapeutic targets in cardiology: Heart failure and arrhythmia: HCN channels
    • Roubille F, Tardif JC. New therapeutic targets in cardiology: Heart failure and arrhythmia: HCN channels. Circulation 127(19), 1986-1996 (2013).
    • (2013) Circulation , vol.127 , Issue.19 , pp. 1986-1996
    • Roubille, F.1    Tardif, J.C.2
  • 73
    • 78650921528 scopus 로고    scopus 로고
    • Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis
    • Busseuil D, Shi Y, Mecteau M et al. Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis. Cardiology 117(3), 234-242 (2010).
    • (2010) Cardiology , vol.117 , Issue.3 , pp. 234-242
    • Busseuil, D.1    Shi, Y.2    Mecteau, M.3
  • 74
    • 84860218769 scopus 로고    scopus 로고
    • Role of heart rate reduction in the prevention of experimental heart failure: Comparison between If-channel blockade and beta-receptor blockade
    • Becher PM, Lindner D, Miteva K et al. Role of heart rate reduction in the prevention of experimental heart failure: Comparison between If-channel blockade and beta-receptor blockade. Hypertension 59(5), 949-957 (2012).
    • (2012) Hypertension , vol.59 , Issue.5 , pp. 949-957
    • Becher, P.M.1    Lindner, D.2    Miteva, K.3
  • 75
    • 84865991500 scopus 로고    scopus 로고
    • Could heart rate play a role in pericardial inflammation?
    • Khoueiry Z, Roubille C, Nagot N et al. Could heart rate play a role in pericardial inflammation? Med. Hypotheses 79(4), 512-515 (2012).
    • (2012) Med. Hypotheses , vol.79 , Issue.4 , pp. 512-515
    • Khoueiry, Z.1    Roubille, C.2    Nagot, N.3
  • 76
    • 84873723928 scopus 로고    scopus 로고
    • Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis
    • Li YC, Luo Q, Ge LS et al. Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis. Biochem. Biophys. Res. Commun. 431(3), 450-455 (2013).
    • (2013) Biochem. Biophys. Res. Commun. , vol.431 , Issue.3 , pp. 450-455
    • Li, Y.C.1    Luo, Q.2    Ge, L.S.3
  • 77
    • 0024829156 scopus 로고
    • Effect of long-term treatment with beta-blocker on cardiac hypertrophy in shr
    • Ieki K, Yazaki Y, Yamaoki K et al. Effect of long-term treatment with beta-blocker on cardiac hypertrophy in shr. J. Mol. Cell. Cardiol. 21(Suppl. 5), 113-119 (1989).
    • (1989) J. Mol. Cell. Cardiol. , vol.21 , Issue.SUPPL. 5 , pp. 113-119
    • Ieki, K.1    Yazaki, Y.2    Yamaoki, K.3
  • 78
    • 4043134412 scopus 로고    scopus 로고
    • Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice
    • Liao Y, Asakura M, Takashima S et al. Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice. Circulation 110(6), 692-699 (2004).
    • (2004) Circulation , vol.110 , Issue.6 , pp. 692-699
    • Liao, Y.1    Asakura, M.2    Takashima, S.3
  • 79
    • 48849100160 scopus 로고    scopus 로고
    • Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure
    • Bartholomeu JB, Vanzelli AS, Rolim NP et al. Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. J. Mol. Cell. Cardiol. 45(2), 240-249 (2008).
    • (2008) J. Mol. Cell. Cardiol. , vol.45 , Issue.2 , pp. 240-249
    • Bartholomeu, J.B.1    Vanzelli, A.S.2    Rolim, N.P.3
  • 80
    • 84872163587 scopus 로고    scopus 로고
    • Deletion of fn14 receptor protects from right heart fibrosis and dysfunction
    • Novoyatleva T, Schymura Y, Janssen W et al. Deletion of fn14 receptor protects from right heart fibrosis and dysfunction. Basic Res. Cardiol. 108(2), 325 (2013).
    • (2013) Basic Res. Cardiol. , vol.108 , Issue.2 , pp. 325
    • Novoyatleva, T.1    Schymura, Y.2    Janssen, W.3
  • 81
    • 80855143703 scopus 로고    scopus 로고
    • The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions
    • Zhang W, Chancey AL, Tzeng HP et al. The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions. Circulation 124(19), 2106-2116 (2011).
    • (2011) Circulation , vol.124 , Issue.19 , pp. 2106-2116
    • Zhang, W.1    Chancey, A.L.2    Tzeng, H.P.3
  • 82
    • 64549087652 scopus 로고    scopus 로고
    • Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: Role of nuclear factor-kappab and inflammatory activation
    • Hamid T, Gu Y, Ortines RV et al. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappab and inflammatory activation. Circulation 119(10), 1386-1397 (2009).
    • (2009) Circulation , vol.119 , Issue.10 , pp. 1386-1397
    • Hamid, T.1    Gu, Y.2    Ortines, R.V.3
  • 83
    • 34249882513 scopus 로고    scopus 로고
    • IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
    • Sanada S, Hakuno D, Higgins LJ, Schreiter ER, McKenzie AN, Lee RT. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J. Clin. Invest. 117(6), 1538-1549 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.6 , pp. 1538-1549
    • Sanada, S.1    Hakuno, D.2    Higgins, L.J.3    Schreiter, E.R.4    McKenzie, A.N.5    Lee, R.T.6
  • 84
    • 84880507499 scopus 로고    scopus 로고
    • ST2 as a cardiovascular risk biomarker: From the bench to the bedside
    • Januzzi JL Jr. ST2 as a cardiovascular risk biomarker: From the bench to the bedside. J. Cardiovasc. Transl. Res. 6(4), 493-500 (2013).
    • (2013) J. Cardiovasc. Transl. Res. , vol.6 , Issue.4 , pp. 493-500
    • Januzzi, Jr.J.L.1
  • 85
    • 73349089976 scopus 로고    scopus 로고
    • Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways
    • Honsho S, Nishikawa S, Amano K et al. Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways. Circ. Res. 105(11), 1149-1158 (2009).
    • (2009) Circ. Res. , vol.105 , Issue.11 , pp. 1149-1158
    • Honsho, S.1    Nishikawa, S.2    Amano, K.3
  • 86
    • 84857956806 scopus 로고    scopus 로고
    • Regression of cardiac hypertrophy by granulocyte colony-stimulating factorstimulated interleukin-1beta synthesis
    • Szardien S, Nef HM, Voss S et al. Regression of cardiac hypertrophy by granulocyte colony-stimulating factorstimulated interleukin-1beta synthesis. Eur. Heart J. 33(5), 595-605 (2012).
    • (2012) Eur. Heart J. , vol.33 , Issue.5 , pp. 595-605
    • Szardien, S.1    Nef, H.M.2    Voss, S.3
  • 87
    • 46749144616 scopus 로고    scopus 로고
    • Interleukin-1 receptor Type i signaling critically regulates infarct healing and cardiac remodeling
    • Bujak M, Dobaczewski M, Chatila K et al. Interleukin-1 receptor Type I signaling critically regulates infarct healing and cardiac remodeling. Am. J. Pathol. 173(1), 57-67 (2008).
    • (2008) Am. J. Pathol. , vol.173 , Issue.1 , pp. 57-67
    • Bujak, M.1    Dobaczewski, M.2    Chatila, K.3
  • 88
    • 76649086709 scopus 로고    scopus 로고
    • Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction
    • Obana M, Maeda M, Takeda K et al. Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121(5), 684-691 (2010).
    • (2010) Circulation , vol.121 , Issue.5 , pp. 684-691
    • Obana, M.1    Maeda, M.2    Takeda, K.3
  • 89
    • 77955500182 scopus 로고    scopus 로고
    • Interleukin mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats
    • Melendez GC, McLarty JL, Levick SP, Du Y, Janicki JS, Brower GL Interleukin mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension 56(2), 225-231 (2010).
    • (2010) Hypertension , vol.56 , Issue.2 , pp. 225-231
    • Melendez, G.C.1    McLarty, J.L.2    Levick, S.P.3    Du, Y.4    Janicki, J.S.5    Brower, G.L.6
  • 91
    • 20844462878 scopus 로고    scopus 로고
    • Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction
    • Sharma UC, Pokharel S, van Brakel TJ et al. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation 110(19), 3121-3128 (2004).
    • (2004) Circulation , vol.110 , Issue.19 , pp. 3121-3128
    • Sharma, U.C.1    Pokharel, S.2    Van Brakel, T.J.3
  • 92
    • 84880253976 scopus 로고    scopus 로고
    • What is the role of erythropoietin in acute myocardial infarct? Bridging the gap between experimental models and clinical trials
    • Roubille F, Prunier F, Barrere-Lemaire S et al. What is the role of erythropoietin in acute myocardial infarct? Bridging the gap between experimental models and clinical trials. Cardiovasc. Drugs Ther. 27(4), 315-331 (2013).
    • (2013) Cardiovasc. Drugs Ther. , vol.27 , Issue.4 , pp. 315-331
    • Roubille, F.1    Prunier, F.2    Barrere-Lemaire, S.3
  • 93
    • 4444310715 scopus 로고    scopus 로고
    • Cardiac remodeling in erythropoietin-transgenic mice
    • Briest W, Homagk L, Baba HA et al. Cardiac remodeling in erythropoietin-transgenic mice. Cell. Physiol. Biochem. 14(4-6), 277-284 (2004).
    • (2004) Cell. Physiol. Biochem. , vol.14 , Issue.4-6 , pp. 277-284
    • Briest, W.1    Homagk, L.2    Baba, H.A.3
  • 94
    • 0033921549 scopus 로고    scopus 로고
    • Cyclosporin a inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats
    • Oie E, Bjornerheim R, Clausen OP, Attramadal H. Cyclosporin a inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats. Am. J. Physiol. Heart Circ. Physiol. 278(6), H2115-2123 (2000).
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.278 , Issue.6
    • Oie, E.1    Bjornerheim, R.2    Clausen, O.P.3    Attramadal, H.4
  • 95
    • 0034925479 scopus 로고    scopus 로고
    • Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis
    • Yang G, Meguro T, Hong C et al. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be due to apoptosis and fibrosis. J. Mol. Cell. Cardiol. 33(8), 1505-1514 (2001).
    • (2001) J. Mol. Cell. Cardiol. , vol.33 , Issue.8 , pp. 1505-1514
    • Yang, G.1    Meguro, T.2    Hong, C.3
  • 96
    • 0037065888 scopus 로고    scopus 로고
    • Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy
    • Takeda Y, Yoneda T, Demura M, Usukura M, Mabuchi H. Calcineurin inhibition attenuates mineralocorticoid-induced cardiac hypertrophy. Circulation 105(6), 677-679 (2002).
    • (2002) Circulation , vol.105 , Issue.6 , pp. 677-679
    • Takeda, Y.1    Yoneda, T.2    Demura, M.3    Usukura, M.4    Mabuchi, H.5
  • 97
    • 78951482658 scopus 로고    scopus 로고
    • Mitochondria-targeted cardioprotection in aldosteronism
    • Shahbaz AU, Kamalov G, Zhao W et al. Mitochondria-targeted cardioprotection in aldosteronism. J. Cardiovasc. Pharmacol. 57(1), 37-43 (2011).
    • (2011) J. Cardiovasc. Pharmacol. , vol.57 , Issue.1 , pp. 37-43
    • Shahbaz, A.U.1    Kamalov, G.2    Zhao, W.3
  • 98
    • 79959525058 scopus 로고    scopus 로고
    • Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy
    • Dai DF, Chen T, Szeto H et al. Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. J. Am. Coll. Cardiol. 58(1), 73-82 (2011).
    • (2011) J. Am. Coll. Cardiol. , vol.58 , Issue.1 , pp. 73-82
    • Dai, D.F.1    Chen, T.2    Szeto, H.3
  • 99
    • 84870064722 scopus 로고    scopus 로고
    • Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats
    • Wang ZF, Wang NP, Harmouche S et al. Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats. Basic Res. Cardiol. 108(1)
    • Basic Res. Cardiol. , vol.108 , Issue.1
    • Wang, Z.F.1    Wang, N.P.2    Harmouche, S.3
  • 100
    • 58149104494 scopus 로고    scopus 로고
    • Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload
    • Nagayama T, Hsu S, Zhang M et al. Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload. J. Am. Coll. Cardiol. 53(2), 207-215 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , Issue.2 , pp. 207-215
    • Nagayama, T.1    Hsu, S.2    Zhang, M.3
  • 101
    • 84868219699 scopus 로고    scopus 로고
    • Selective PDE5A II inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin ii-induced heart failure in vivo
    • Westermann D, Becher PM, Lindner D et al. Selective PDE5A II inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin ii-induced heart failure in vivo. Basic Res. Cardiol. 107(6)
    • Basic Res. Cardiol. , vol.107 , pp. 6
    • Westermann, D.1    Becher, P.M.2    Lindner, D.3
  • 102
    • 84864753099 scopus 로고    scopus 로고
    • Effects of sildenafil and/or muscle derived stem cells on myocardial infarction
    • Wang JS, Kovanecz I, Vernet D et al. Effects of sildenafil and/or muscle derived stem cells on myocardial infarction. J. Transl. Med. 10, 159 (2012).
    • (2012) J. Transl. Med. , vol.10 , pp. 159
    • Wang, J.S.1    Kovanecz, I.2    Vernet, D.3
  • 103
    • 84862777601 scopus 로고    scopus 로고
    • Long-term effects of sildenafil in a rat model of chronic mitral regurgitation: Benefits of ventricular remodeling and exercise capacity
    • Kim KH, Kim YJ, Ohn JH et al. Long-term effects of sildenafil in a rat model of chronic mitral regurgitation: Benefits of ventricular remodeling and exercise capacity. Circulation 125(11), 1390-1401 (2012).
    • (2012) Circulation , vol.125 , Issue.11 , pp. 1390-1401
    • Kim, K.H.1    Kim, Y.J.2    Ohn, J.H.3
  • 105
    • 84861234413 scopus 로고    scopus 로고
    • Chronic inhibition of CGMP phosphodiesterase 5a improves diabetic cardiomyopathy: A randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging
    • Giannetta E, Isidori AM, Galea N et al. Chronic inhibition of CGMP phosphodiesterase 5a improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging. Circulation 125(19), 2323-2333 (2012).
    • (2012) Circulation , vol.125 , Issue.19 , pp. 2323-2333
    • Giannetta, E.1    Isidori, A.M.2    Galea, N.3
  • 106
    • 1942484870 scopus 로고    scopus 로고
    • Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-b pathway
    • Ogata T, Miyauchi T, Sakai S, Takanashi M, Irukayama-Tomobe Y, Yamaguchi I. Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-b pathway. J. Am. Coll. Cardiol. 43(8), 1481-1488 (2004).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , Issue.8 , pp. 1481-1488
    • Ogata, T.1    Miyauchi, T.2    Sakai, S.3    Takanashi, M.4    Irukayama-Tomobe, Y.5    Yamaguchi, I.6
  • 107
    • 84871103294 scopus 로고    scopus 로고
    • Stem cell transplantation as a therapy for cardiac fibrosis
    • Elnakish MT, Kuppusamy P, Khan M. Stem cell transplantation as a therapy for cardiac fibrosis. J. Pathol. 229(2), 347-354 (2013).
    • (2013) J. Pathol. , vol.229 , Issue.2 , pp. 347-354
    • Elnakish, M.T.1    Kuppusamy, P.2    Khan, M.3
  • 108
    • 84879371157 scopus 로고    scopus 로고
    • Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts
    • Uchinaka A, Kawaguchi N, Hamada Y et al. Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts. Cardiovasc. Res. 99(1), 102-110 (2013).
    • (2013) Cardiovasc. Res. , vol.99 , Issue.1 , pp. 102-110
    • Uchinaka, A.1    Kawaguchi, N.2    Hamada, Y.3
  • 109
    • 84865273299 scopus 로고    scopus 로고
    • Cardiac fibrosis revisited by microrna therapeutics
    • Thum T, Lorenzen JM. Cardiac fibrosis revisited by microrna therapeutics. Circulation 126(7), 800-802 (2012).
    • (2012) Circulation , vol.126 , Issue.7 , pp. 800-802
    • Thum, T.1    Lorenzen, J.M.2
  • 110
    • 78650170396 scopus 로고    scopus 로고
    • Regulation of myocardial fibrosis by micrornas
    • Bauersachs J. Regulation of myocardial fibrosis by micrornas. J. Cardiovasc. Pharmacol. 56(5), 454-459 (2010).
    • (2010) J. Cardiovasc. Pharmacol. , vol.56 , Issue.5 , pp. 454-459
    • Bauersachs, J.1
  • 111
    • 84865206803 scopus 로고    scopus 로고
    • Microrna-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the fbj osteosarcoma oncogene/transforming growth factor-beta1 pathway
    • Pan Z, Sun X, Shan H et al. Microrna-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the fbj osteosarcoma oncogene/transforming growth factor-beta1 pathway. Circulation 126(7), 840-850 (2012).
    • (2012) Circulation , vol.126 , Issue.7 , pp. 840-850
    • Pan, Z.1    Sun, X.2    Shan, H.3
  • 112
    • 84859720170 scopus 로고    scopus 로고
    • Microrna-214 protects the mouse heart from ischemic injury by controlling ca(2)(+) overload and cell death
    • Aurora AB, Mahmoud AI, Luo X et al. Microrna-214 protects the mouse heart from ischemic injury by controlling ca(2)(+) overload and cell death. J. Clin. Invest. 122(4), 1222-1232 (2012).
    • (2012) J. Clin. Invest. , vol.122 , Issue.4 , pp. 1222-1232
    • Aurora, A.B.1    Mahmoud, A.I.2    Luo, X.3
  • 113
    • 79958282599 scopus 로고    scopus 로고
    • Role of micrornas in cardiac remodeling and heart failure
    • Topkara VK, Mann DL. Role of micrornas in cardiac remodeling and heart failure. Cardiovasc. Drugs Ther. 25(2), 171-182 (2011).
    • (2011) Cardiovasc. Drugs Ther. , vol.25 , Issue.2 , pp. 171-182
    • Topkara, V.K.1    Mann, D.L.2
  • 114
    • 84867733433 scopus 로고    scopus 로고
    • Mir-21: A central regulator of fibrosis not only in the broken heart
    • discussion 230-223
    • Bauersachs J. Mir-21: a central regulator of fibrosis not only in the broken heart. Cardiovasc. Res. 96(2), 227-229, discussion 230-223 (2012).
    • (2012) Cardiovasc. Res. , vol.96 , Issue.2 , pp. 227-229
    • Bauersachs, J.1
  • 115
    • 84856171521 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced endothelial-to-mesenchymal transition is partly mediated by microrna-21
    • Kumarswamy R, Volkmann I, Jazbutyte V, Dangwal S, Park DH, Thum T. Transforming growth factor-beta-induced endothelial-to-mesenchymal transition is partly mediated by microrna-21. Arterioscler. Thromb. Vasc. Biol. 32(2), 361-369 (2012).
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , Issue.2 , pp. 361-369
    • Kumarswamy, R.1    Volkmann, I.2    Jazbutyte, V.3    Dangwal, S.4    Park, D.H.5    Thum, T.6
  • 116
    • 55449100829 scopus 로고    scopus 로고
    • Toward microrna-based therapeutics for heart disease: The sense in antisense
    • van Rooij E, Marshall WS, Olson EN. Toward microrna-based therapeutics for heart disease: The sense in antisense. Circ. Res. 103(9), 919-928 (2008).
    • (2008) Circ. Res. , vol.103 , Issue.9 , pp. 919-928
    • Van Rooij, E.1    Marshall, W.S.2    Olson, E.N.3
  • 117
    • 59849114044 scopus 로고    scopus 로고
    • Searching for mir-acles in cardiac fibrosis
    • van Rooij E, Olson EN: Searching for mir-acles in cardiac fibrosis. Circ. Res. 104(2), 138-140 (2009).
    • (2009) Circ. Res. , vol.104 , Issue.2 , pp. 138-140
    • Van Rooij, E.1    Olson, E.N.2
  • 118
    • 57749168828 scopus 로고    scopus 로고
    • Microrna-21 contributes to myocardial disease by stimulating map kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J et al. Microrna-21 contributes to myocardial disease by stimulating map kinase signalling in fibroblasts. Nature 456(7224), 980-984 (2008).
    • (2008) Nature , vol.456 , Issue.7224 , pp. 980-984
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 119
    • 51349141401 scopus 로고    scopus 로고
    • Dysregulation of micrornas after myocardial infarction reveals a role of mir-29 in cardiac fibrosis
    • van Rooij E, Sutherland LB, Thatcher JE et al. Dysregulation of micrornas after myocardial infarction reveals a role of mir-29 in cardiac fibrosis. Proc. Natl Acad. Sci. USA 105(35), 13027-13032 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.35 , pp. 13027-13032
    • Van Rooij, E.1    Sutherland, L.B.2    Thatcher, J.E.3
  • 120
    • 84867903854 scopus 로고    scopus 로고
    • Therapeutic inhibition of the mir-34 family attenuates pathological cardiac remodeling and improves heart function
    • Bernardo BC, Gao XM, Winbanks CE et al. Therapeutic inhibition of the mir-34 family attenuates pathological cardiac remodeling and improves heart function. Proc. Natl Acad. Sci. USA 109(43), 17615-17620 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.43 , pp. 17615-17620
    • Bernardo, B.C.1    Gao, X.M.2    Winbanks, C.E.3
  • 121
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10(5), 927-939 (2005).
    • (2005) Apoptosis , vol.10 , Issue.5 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 122
    • 34047148354 scopus 로고    scopus 로고
    • The role of tgf-beta signaling in myocardial infarction and cardiac remodeling
    • Bujak M, Frangogiannis NG. The role of tgf-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc. Res. 74(2), 184-195 (2007).
    • (2007) Cardiovasc. Res. , vol.74 , Issue.2 , pp. 184-195
    • Bujak, M.1    Frangogiannis, N.G.2
  • 123
    • 54949128696 scopus 로고    scopus 로고
    • Fibrosis and cirrhosis reversibility -molecular mechanisms
    • xi
    • Gieling RG, Burt AD, Mann DA. Fibrosis and cirrhosis reversibility -molecular mechanisms. Clin. Liver Dis. 12(4), 915-937, xi (2008).
    • (2008) Clin. Liver Dis. , vol.12 , Issue.4 , pp. 915-937
    • Gieling, R.G.1    Burt, A.D.2    Mann, D.A.3
  • 124
    • 70349659185 scopus 로고    scopus 로고
    • Angiotensin II induces connective tissue growth factor and collagen i expression via transforming growth factor-beta-dependent and -independent smad pathways: The role of smad3
    • Yang F, Chung AC, Huang XR, Lan HY. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent smad pathways: the role of smad3. Hypertension 54(4), 877-884 (2009).
    • (2009) Hypertension , vol.54 , Issue.4 , pp. 877-884
    • Yang, F.1    Chung, A.C.2    Huang, X.R.3    Lan, H.Y.4
  • 125
    • 2542609844 scopus 로고    scopus 로고
    • Smad3 as a mediator of the fibrotic response
    • Flanders KC. Smad3 as a mediator of the fibrotic response. Int. J. Exp. Pathol. 85(2), 47-64 (2004).
    • (2004) Int. J. Exp. Pathol. , vol.85 , Issue.2 , pp. 47-64
    • Flanders, K.C.1
  • 126
    • 2442481893 scopus 로고    scopus 로고
    • Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone
    • Xavier S, Piek E, Fujii M et al. Amelioration of radiation-induced fibrosis: Inhibition of transforming growth factor-beta signaling by halofuginone. J. Biol. Chem. 279(15), 15167-15176 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.15 , pp. 15167-15176
    • Xavier, S.1    Piek, E.2    Fujii, M.3
  • 127
    • 11244292291 scopus 로고    scopus 로고
    • Imatinib mesylate blocks a non-smad TGF-beta pathway and reduces renal fibrogenesis in vivo
    • Wang S, Wilkes MC, Leof EB, Hirschberg R. Imatinib mesylate blocks a non-smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J. 19(1), 1-11 (2005).
    • (2005) FASEB J , vol.19 , Issue.1 , pp. 1-11
    • Wang, S.1    Wilkes, M.C.2    Leof, E.B.3    Hirschberg, R.4
  • 128
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • Daniels CE, Wilkes MC, Edens M et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J. Clin. Invest. 114(9), 1308-1316 (2004).
    • (2004) J. Clin. Invest. , vol.114 , Issue.9 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3
  • 130
    • 84875329507 scopus 로고    scopus 로고
    • Salvianolic acid a, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats
    • Jiang B, Li D, Deng Y et al. Salvianolic acid a, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats. PLoS ONE 8(3), e59621 (2013).
    • (2013) PLoS ONE , vol.8 , Issue.3
    • Jiang, B.1    Li, D.2    Deng, Y.3
  • 131
    • 84869389745 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice
    • Chiao YA, Ramirez TA, Zamilpa R et al. Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice. Cardiovasc. Res. 96(3), 444-455 (2012).
    • (2012) Cardiovasc. Res. , vol.96 , Issue.3 , pp. 444-455
    • Chiao, Y.A.1    Ramirez, T.A.2    Zamilpa, R.3
  • 132
    • 80054912866 scopus 로고    scopus 로고
    • Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8
    • Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S: Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. Am. J. Physiol. Cell Physiol. 301(5), C1046-C1056 (2011).
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301 , Issue.5
    • Georgescu, S.P.1    Aronovitz, M.J.2    Iovanna, J.L.3    Patten, R.D.4    Kyriakis, J.M.5    Goruppi, S.6
  • 133
    • 80053144553 scopus 로고    scopus 로고
    • Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion
    • Oyamada S, Bianchi C, Takai S, Chu LM, Sellke FW. Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion. J. Pharmacol. Exp. Ther. 339(1), 143-151 (2011).
    • (2011) J. Pharmacol. Exp. Ther. , vol.339 , Issue.1 , pp. 143-151
    • Oyamada, S.1    Bianchi, C.2    Takai, S.3    Chu, L.M.4    Sellke, F.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.