MiR-21: A central regulator of fibrosis not only in the broken heart

Cardiovascular Research

Volumn 96, Issue 2, 2012, Pages 227-229

  Bauersachs, Johann ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CYTOKINE; MICRORNA 21; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SPROUTY 1 PROTEIN; SPROUTY PROTEIN; STROMELYSIN; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; CELL DIFFERENTIATION; COLLAGEN SYNTHESIS; DISEASE ASSOCIATION; EDITORIAL; ENZYME ACTIVATION; ENZYME REGULATION; EXTRACELLULAR MATRIX; FIBROBLAST; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART VENTRICLE OVERLOAD; INFLAMMATORY CELL; LUNG FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; UPREGULATION; WOUND HEALING;

ANIMALS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MATRIX METALLOPROTEINASE 2; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PTEN PHOSPHOHYDROLASE;

EID: 84867733433     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs200     Document Type: Editorial

References (16)

1. Fraccarollo D, Galuppo P, Bauersachs J. Novel therapeutic approaches to postinfarction remodelling. Cardiovasc Res 2012;94:293-303.
2. Bauersachs J. Regulation of myocardial fibrosis by MicroRNAs. J Cardiovasc Pharmacol 2010;56:454-459.
3. Thum T, Catalucci D, Bauersachs J. MicroRNAs: novel regulators in cardiac development and disease. Cardiovasc Res 2008;79:562-570.
4. Small EM, Olson EN. Pervasive roles of microRNAs in cardiovascular biology. Nature 2011;469:336-342.
5. Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C et al. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res 2009;82:21-29.
6. Souders CA, Bowers SL, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res 2009;105:1164-1176.
7. Frantz S, Bauersachs J, Ertl G. Post-infarct remodelling: contribution of wound healing and inflammation. Cardiovasc Res 2009;81:474-481.
8. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456:980-984.
9. Dong S, Cheng Y, Yang J, Li J, Liu X, Wang X et al. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem 2009;284:29514-29525.
10. Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, Thannickal VJ et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010; 207:1589-1597.
11. Nielsen BS, Jorgensen S, Fog JU, Sokilde R, Christensen IJ, Hansen U et al. High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clin Exp Metastasis 2011;28: 27-38.
12. Kumarswamy R, Volkmann I, Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biology 2011;8:1-8.
13. Kumarswamy R, Volkmann I, Jazbutyte V, Dangwal S, Park DH, Thum T. Transforming growth factor-beta-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21. Arterioscler Thromb Vasc Biol 2012;32:361-369.
14. Tijsen AJ, Pinto YM, Creemers EE. Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res 2012;93:573-582.
15. Bauersachs J, Thum T. Biogenesis and regulation of cardiovascular microRNAs. Circ Res 2011;109:334-347.
16. Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q et al. Asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21 dependent mechanism. Circ Res 2010;107: 138-193.