메뉴 건너뛰기




Volumn 92, Issue 5, 2012, Pages 613-621

The TGF-β pathway as an emerging target for chagas disease therapy

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTISENSE OLIGONUCLEOTIDE; AP 11014; BENZNIDAZOLE; BIOLOGICAL MARKER; CYTOKINE; DIGITALIS; DISITERTIDE; DIURETIC AGENT; FRESOLIMUMAB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN; INTERLEUKIN 6; LERDELIMUMAB; LY 2157299; LY 2382770; METELIMUMAB; NIFURTIMOX; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRABEDERSEN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG; VASODILATOR AGENT;

EID: 84867885135     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.102     Document Type: Review
Times cited : (44)

References (75)
  • 1
    • 84872601225 scopus 로고    scopus 로고
    • World Health Organization. First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases
    • World Health Organization. First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases http://www.gsk.com/media/downloads/WHO-report-on-NTD.PDF (2011).
    • (2011)
  • 4
    • 68949212150 scopus 로고    scopus 로고
    • Chagas heart disease: Pathophysiologic mechanisms, prognostic factors and risk stratification
    • Rassi Jr, A., Rassi, A. & Marin-Neto, J.A. Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 152-158 (2009).
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , Issue.SUPPL. 1 , pp. 152-158
    • Rassi Jr., A.1    Rassi, A.2    Marin-Neto, J.A.3
  • 5
    • 33947597320 scopus 로고    scopus 로고
    • Pathogenesis of chronic Chagas heart disease
    • DOI 10.1161/CIRCULATIONAHA.106.624296, PII 0000301720070306000009
    • Marin-Neto, J.A., Cunha-Neto, E., Maciel, B.C. & Simöes, M.V. Pathogenesis of chronic Chagas heart disease. Circulation 115, 1109-1123 (2007). (Pubitemid 46679556)
    • (2007) Circulation , vol.115 , Issue.9 , pp. 1109-1123
    • Marin-Neto, J.A.1    Cunha-Neto, E.2    Maciel, B.C.3    Simoes, M.V.4
  • 6
    • 79959793199 scopus 로고    scopus 로고
    • Antitrypanosomal therapy for chronic Chagas' disease
    • Bern, C. Antitrypanosomal therapy for chronic Chagas' disease. N. Engl. J. Med. 364, 2527-2534 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2527-2534
    • Bern, C.1
  • 7
    • 68949220484 scopus 로고    scopus 로고
    • The BENEFIT trial: Testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease
    • Marin-Neto, J.A. et al. The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 319-324 (2009).
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , Issue.SUPPL. 1 , pp. 319-324
    • Marin-Neto, J.A.1
  • 10
    • 80052819014 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-? signaling in cardiac remodeling
    • Dobaczewski, M., Chen, W. & Frangogiannis, N.G. Transforming growth factor (TGF)-? signaling in cardiac remodeling. J. Mol. Cell. Cardiol. 51, 600-606 (2011).
    • (2011) J. Mol. Cell. Cardiol. , vol.51 , pp. 600-606
    • Dobaczewski, M.1    Chen, W.2    Frangogiannis, N.G.3
  • 11
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massagué, J. & Gomis, R.R. The logic of TGFbeta signaling. FEBS Lett. 580, 2811-2820 (2006).
    • (2006) FEBS Lett. , vol.580 , pp. 2811-2820
    • Massagué, J.1    Gomis, R.R.2
  • 12
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas, A. & Heldin, C.H. Non-Smad TGF-beta signals. J. Cell. Sci. 118, 3573-3584 (2005).
    • (2005) J. Cell. Sci. , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 13
    • 79951602633 scopus 로고    scopus 로고
    • Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
    • Bogdahn, U., Hau, P., Stockhammer, G., Venkataramana, N.K., Mahapatra, A.K., Suri, A. Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro. Oncol. 13, 132-142 (2011).
    • (2011) Neuro. Oncol. , vol.13 , pp. 132-142
    • Bogdahn, U.1    Hau, P.2    Stockhammer, G.3    Venkataramana, N.K.4    Mahapatra, A.K.5    Suri, A.6
  • 15
    • 33645665682 scopus 로고    scopus 로고
    • Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N- (tetrahydro-2H-pyran-4-yl)benzamide (GW788388): A potent, selective, and orally active transforming growth factor-beta type i receptor inhibitor
    • Gellibert, F. et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl] pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. J. Med. Chem. 49, 2210-2221 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 2210-2221
    • Gellibert, F.1
  • 18
    • 80053585761 scopus 로고    scopus 로고
    • Induction of heart valve lesions by small-molecule ALK5 inhibitors
    • Anderton, M.J. et al. Induction of heart valve lesions by small-molecule ALK5 inhibitors. Toxicol. Pathol. 39, 916-924 (2011).
    • (2011) Toxicol. Pathol. , vol.39 , pp. 916-924
    • Anderton, M.J.1
  • 19
    • 35348940144 scopus 로고    scopus 로고
    • Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
    • Prud'homme, G.J. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 87, 1077-1091 (2007).
    • (2007) Lab. Invest. , vol.87 , pp. 1077-1091
    • Prud'Homme, G.J.1
  • 20
    • 56949093019 scopus 로고    scopus 로고
    • Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy
    • Araújo-Jorge, T.C., Waghabi, M.C., Soeiro, M.d.e.N., Keramidas, M., Bailly, S. & Feige, J.J. Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine Growth Factor Rev. 19, 405-413 (2008).
    • (2008) Cytokine Growth Factor Rev. , vol.19 , pp. 405-413
    • Araújo-Jorge, T.C.1    Waghabi, M.C.2    De Soeiro, M.N.3    Keramidas, M.4    Bailly, S.5    Feige, J.J.6
  • 21
    • 0025741792 scopus 로고
    • Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta)
    • Silva, J.S., Twardzik, D.R. & Reed, S.G. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta). J. Exp. Med. 174, 539-545 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 539-545
    • Silva, J.S.1    Twardzik, D.R.2    Reed, S.G.3
  • 24
    • 79958004980 scopus 로고    scopus 로고
    • Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease
    • Pérez, A.R. et al. Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. J. Neuroimmunol. 235, 84-90 (2011).
    • (2011) J. Neuroimmunol. , vol.235 , pp. 84-90
    • Pérez, A.R.1
  • 25
    • 0034328991 scopus 로고    scopus 로고
    • Growth factors in the myocardium of patients with chronic chagasic cardiomyopathy
    • Reis, M.M., Higuchi, M.d.e.L., Aiello, V.D. & Benvenuti, L.A. [Growth factors in the myocardium of patients with chronic chagasic cardiomyopathy]. Rev. Soc. Bras. Med. Trop. 33, 509-518 (2000).
    • (2000) Rev. Soc. Bras. Med. Trop. , vol.33 , pp. 509-518
    • Reis, M.M.1    De Higuchi, M.L.2    Aiello, V.D.3    Benvenuti, L.A.4
  • 26
    • 72449171585 scopus 로고    scopus 로고
    • Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection
    • Waghabi, M.C. et al. Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection. Mem. Inst. Oswaldo Cruz 104, 1083-1090 (2009).
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , pp. 1083-1090
    • Waghabi, M.C.1
  • 27
    • 68949219809 scopus 로고    scopus 로고
    • The effects of nitric oxide on the immune system during Trypanosoma cruzi infection
    • Gutierrez, F.R., Mineo, T.W., Pavanelli, W.R., Guedes, P.M. & Silva, J.S. The effects of nitric oxide on the immune system during Trypanosoma cruzi infection. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 236-245 (2009).
    • (2009) Mem. Inst. Oswaldo Cruz , vol.104 , Issue.SUPPL. 1 , pp. 236-245
    • Gutierrez, F.R.1    Mineo, T.W.2    Pavanelli, W.R.3    Guedes, P.M.4    Silva, J.S.5
  • 28
    • 79960364782 scopus 로고    scopus 로고
    • Exploring anti-TGF-? therapies in cancer and fibrosis
    • Hawinkels, L.J. & Ten Dijke, P. Exploring anti-TGF-? therapies in cancer and fibrosis. Growth Factors 29, 140-152 (2011).
    • (2011) Growth Factors , vol.29 , pp. 140-152
    • Hawinkels, L.J.1    Ten Dijke, P.2
  • 29
    • 79961139550 scopus 로고    scopus 로고
    • TGF-?/TGF-? receptor system and its role in physiological and pathological conditions
    • Santibañez, J.F., Quintanilla, M. & Bernabeu, C. TGF-?/TGF-? receptor system and its role in physiological and pathological conditions. Clin. Sci. 121, 233-251 (2011).
    • (2011) Clin. Sci. , vol.121 , pp. 233-251
    • Santibañez, J.F.1    Quintanilla, M.2    Bernabeu, C.3
  • 30
    • 0036719851 scopus 로고    scopus 로고
    • Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin
    • Waghabi, M.C. et al. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. Infect. Immun. 70, 5115-5123 (2002).
    • (2002) Infect. Immun. , vol.70 , pp. 5115-5123
    • Waghabi, M.C.1
  • 31
    • 70350307193 scopus 로고    scopus 로고
    • Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease
    • Waghabi, M.C. et al. Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease. Antimicrob. Agents Chemother. 53, 4694-4701 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4694-4701
    • Waghabi, M.C.1
  • 33
    • 0028987602 scopus 로고
    • The TGF beta superfamily in myocardium: Ligands, receptors, transduction, and function
    • Brand, T. & Schneider, M.D. The TGF beta superfamily in myocardium: ligands, receptors, transduction, and function. J. Mol. Cell. Cardiol. 27, 5-18 (1995).
    • (1995) J. Mol. Cell. Cardiol. , vol.27 , pp. 5-18
    • Brand, T.1    Schneider, M.D.2
  • 34
    • 33751259883 scopus 로고    scopus 로고
    • Upregulation of expression of sarcoplasmic reticulum by TGF-beta 1 in cultured rat cardiac myocytes
    • Kimura, H., Takemura, H., Imoto, K., Ohshika, H. & Mochizuki, Y. Upregulation of expression of sarcoplasmic reticulum by TGF-beta 1 in cultured rat cardiac myocytes. Am. J. Physiol. 272, H2639-H2644 (1997).
    • (1997) Am. J. Physiol. , vol.272
    • Kimura, H.1    Takemura, H.2    Imoto, K.3    Ohshika, H.4    Mochizuki, Y.5
  • 35
    • 0026475715 scopus 로고
    • Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1
    • Roberts, A.B., Roche, N.S., Winokur, T.S., Burmester, J.K. & Sporn, M.B. Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1. J. Clin. Invest. 90, 2056-2062 (1992).
    • (1992) J. Clin. Invest. , vol.90 , pp. 2056-2062
    • Roberts, A.B.1    Roche, N.S.2    Winokur, T.S.3    Burmester, J.K.4    Sporn, M.B.5
  • 36
    • 33645806742 scopus 로고    scopus 로고
    • Fibrosis in heart disease: Understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
    • Khan, R. & Sheppard, R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118, 10-24 (2006).
    • (2006) Immunology , vol.118 , pp. 10-24
    • Khan, R.1    Sheppard, R.2
  • 37
    • 0033813219 scopus 로고    scopus 로고
    • Induction of cardiac fibrosis by transforming growth factor-beta(1)
    • Lijnen, P.J., Petrov, V.V. & Fagard, R.H. Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol. Genet. Metab. 71, 418-435 (2000).
    • (2000) Mol. Genet. Metab. , vol.71 , pp. 418-435
    • Lijnen, P.J.1    Petrov, V.V.2    Fagard, R.H.3
  • 38
    • 33750490112 scopus 로고    scopus 로고
    • Angiotensin II stimulates apoptosis via TGF-beta1 signaling in ventricular cardiomyocytes of rat
    • DOI 10.1007/s00109-006-0090-0
    • Schröder, D., Heger, J., Piper, H.M. & Euler, G. Angiotensin II stimulates apoptosis via TGF-beta1 signaling in ventricular cardiomyocytes of rat. J. Mol. Med. 84, 975-983 (2006). (Pubitemid 44655875)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.11 , pp. 975-983
    • Schroder, D.1    Heger, J.2    Piper, H.M.3    Euler, G.4
  • 39
    • 0028783296 scopus 로고
    • Induction of hypertrophic responsiveness to isoproterenol by TGF-beta in adult rat cardiomyocytes
    • Schlüter, K.D., Zhou, X.J. & Piper, H.M. Induction of hypertrophic responsiveness to isoproterenol by TGF-beta in adult rat cardiomyocytes. Am. J. Physiol. 269, C1311-C1316 (1995). (Pubitemid 3005892)
    • (1995) The American journal of physiology , vol.269 , Issue.51
    • Schluter, K.D.1    Zhou Xi-Juan2    Piper, H.M.3
  • 40
    • 0037023644 scopus 로고    scopus 로고
    • Autocrine regulation of myocyte Cx43 expression by VEGF
    • DOI 10.1161/01.RES.0000014823.75393.4D
    • Pimentel, R.C., Yamada, K.A., Kléber, A.G. & Saffitz, J.E. Autocrine regulation of myocyte Cx43 expression by VEGF. Circ. Res. 90, 671-677 (2002). (Pubitemid 34640885)
    • (2002) Circulation Research , vol.90 , Issue.6 , pp. 671-677
    • Pimentel, R.C.1    Yamada, K.A.2    Kleber, A.G.3    Saffitz, J.E.4
  • 43
    • 77956627158 scopus 로고    scopus 로고
    • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
    • Dobaczewski, M. et al. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ. Res. 107, 418-428 (2010).
    • (2010) Circ. Res. , vol.107 , pp. 418-428
    • Dobaczewski, M.1
  • 44
    • 79951471956 scopus 로고    scopus 로고
    • Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
    • DosReis, G.A. Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease. Braz. J. Med. Biol. Res. 44, 84-90 (2011).
    • (2011) Braz. J. Med. Biol. Res. , vol.44 , pp. 84-90
    • Dosreis, G.A.1
  • 46
    • 35348907342 scopus 로고    scopus 로고
    • + T cell dysfunction during experimental Trypanosoma cruzi infection
    • DOI 10.1002/eji.200737033
    • Martin, D.L., Postan, M., Lucas, P., Gress, R. & Tarleton, R.L. TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection. Eur. J. Immunol. 37, 2764-2771 (2007). (Pubitemid 47578295)
    • (2007) European Journal of Immunology , vol.37 , Issue.10 , pp. 2764-2771
    • Martin, D.L.1    Postan, M.2    Lucas, P.3    Gress, R.4    Tarleton, R.L.5
  • 47
    • 0030048074 scopus 로고    scopus 로고
    • Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: Lack of association between susceptibility and type 2 cytokine production
    • Zhang, L. & Tarleton, R.L. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur. J. Immunol. 26, 102-109 (1996).
    • (1996) Eur. J. Immunol. , vol.26 , pp. 102-109
    • Zhang, L.1    Tarleton, R.L.2
  • 48
    • 84863669381 scopus 로고    scopus 로고
    • Oral administration of GW788388, an inhibitor of transforming growth factor-beta signaling, prevents heart fibrosis in Chagas disease
    • de Oliveira, F., Araújo-Jorge, T., de Souza, E., de Oliveira, G., Degrave, W., Feige, J. Oral administration of GW788388, an inhibitor of transforming growth factor-beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl. Trop. Dis. 6, e1696 (2012).
    • (2012) PLoS Negl. Trop. Dis. , vol.6
    • De Oliveira, F.1    Araújo-Jorge, T.2    De Souza, E.3    De Oliveira, G.4    Degrave, W.5    Feige, J.6
  • 49
    • 0036596094 scopus 로고    scopus 로고
    • Effects of immunomodulators on acute Trypanosoma cruzi infection in mice
    • Oz, H.S., Hughes, W.T., Thomas, E.K. & McClain, C.J. Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice. Med. Sci. Monit. 8, BR208-BR211 (2002). (Pubitemid 34694641)
    • (2002) Medical Science Monitor , vol.8 , Issue.6
    • Oz, H.S.1    Hughes, W.T.2    Thomas, E.K.3    McClain, C.J.4
  • 50
    • 61449103434 scopus 로고    scopus 로고
    • Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage
    • Medeiros, G.A. et al. Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage. Microbes Infect. 11, 264-273 (2009).
    • (2009) Microbes Infect. , vol.11 , pp. 264-273
    • Medeiros, G.A.1
  • 51
    • 67650650681 scopus 로고    scopus 로고
    • Short treatment with the tumour necrosis factor-alpha blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation
    • Pérez, A.R., Fontanella, G.H., Nocito, A.L., Revelli, S. & Bottasso, O.A. Short treatment with the tumour necrosis factor-alpha blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation. Clin. Exp. Immunol. 157, 291-299 (2009).
    • (2009) Clin. Exp. Immunol. , vol.157 , pp. 291-299
    • Pérez, A.R.1    Fontanella, G.H.2    Nocito, A.L.3    Revelli, S.4    Bottasso, O.A.5
  • 52
    • 84860396946 scopus 로고    scopus 로고
    • Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection
    • Cutrullis, R.A., Poklépovich, T.J., Postan, M., Freilij, H.L. & Petray, P.B. Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection. Int. Immunopharmacol. 11, 1024-1031 (2011).
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 1024-1031
    • Cutrullis, R.A.1    Poklépovich, T.J.2    Postan, M.3    Freilij, H.L.4    Petray, P.B.5
  • 53
    • 0025864397 scopus 로고
    • Chagas' cardioneuropathy: Effect of ganglioside treatment in chronic dysautonomic patients-A randomized, double-blind, parallel, placebo-controlled study
    • Iosa, D., Massari, D.C. & Dorsey, F.C. Chagas' cardioneuropathy: effect of ganglioside treatment in chronic dysautonomic patients-a randomized, double-blind, parallel, placebo-controlled study. Am. Heart J. 122, 775-785 (1991).
    • (1991) Am. Heart J. , vol.122 , pp. 775-785
    • Iosa, D.1    Massari, D.C.2    Dorsey, F.C.3
  • 54
    • 0032758981 scopus 로고    scopus 로고
    • Long-term treatment of chronic chagasic cardioneuropathy with a mixture of gangliosides: Effect on evolution of circulating antiGM1 antibodies
    • Mitelman, J., Gimenez, L., Aparicio, N.J. & Cortelezzi, M. Long-term treatment of chronic chagasic cardioneuropathy with a mixture of gangliosides: effect on evolution of circulating antiGM1 antibodies. J. Cardiol. 34, 189-197 (1999). (Pubitemid 29510334)
    • (1999) Journal of Cardiology , vol.34 , Issue.4 , pp. 189-197
    • Mitelman, J.1    Gimenez, L.2    Aparicio, N.J.3    Cortelezzi, M.4
  • 55
    • 80052147660 scopus 로고    scopus 로고
    • Gap junctions and chagas disease
    • Adesse, D. et al. Gap junctions and chagas disease. Adv. Parasitol. 76, 63-81 (2011).
    • (2011) Adv. Parasitol. , vol.76 , pp. 63-81
    • Adesse, D.1
  • 56
    • 0026583587 scopus 로고
    • Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi
    • de Carvalho, A.C. et al. Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi. Circ. Res. 70, 733-742 (1992).
    • (1992) Circ. Res. , vol.70 , pp. 733-742
    • De Carvalho, A.C.1
  • 57
    • 78249241534 scopus 로고    scopus 로고
    • Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication
    • Zhang, Y., Kanter, E.M. & Yamada, K.A. Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Cardiovasc. Pathol. 19, e233-e240 (2010).
    • (2010) Cardiovasc. Pathol. , vol.19
    • Zhang, Y.1    Kanter, E.M.2    Yamada, K.A.3
  • 58
    • 60249090231 scopus 로고    scopus 로고
    • Role of TGF-beta on cardiac structural and electrical remodeling
    • Ramos-Mondragón, R., Galindo, C.A. & Avila, G. Role of TGF-beta on cardiac structural and electrical remodeling. Vasc. Health Risk Manag. 4, 1289-1300 (2008).
    • (2008) Vasc. Health Risk Manag. , vol.4 , pp. 1289-1300
    • Ramos-Mondragón, R.1    Galindo, C.A.2    Avila, G.3
  • 59
    • 51749110724 scopus 로고    scopus 로고
    • Remodelling of gap junctions and connexin expression in diseased myocardium
    • Severs, N.J., Bruce, A.F., Dupont, E. & Rothery, S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc. Res. 80, 9-19 (2008).
    • (2008) Cardiovasc. Res. , vol.80 , pp. 9-19
    • Severs, N.J.1    Bruce, A.F.2    Dupont, E.3    Rothery, S.4
  • 60
    • 60649121513 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 (TGFbeta1) gene polymorphisms and Chagas disease susceptibility in Peruvian and Colombian patients
    • Calzada, J.E., Beraún, Y., González, C.I. & Martín, J. Transforming growth factor beta 1 (TGFbeta1) gene polymorphisms and Chagas disease susceptibility in Peruvian and Colombian patients. Cytokine 45, 149-153 (2009).
    • (2009) Cytokine , vol.45 , pp. 149-153
    • Calzada, J.E.1    Beraún, Y.2    González, C.I.3    Martín, J.4
  • 61
    • 0025665195 scopus 로고
    • Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy
    • Zicker, F., Smith, P.G., Netto, J.C., Oliveira, R.M. & Zicker, E.M. Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy. Am. J. Trop. Med. Hyg. 43, 498-505 (1990).
    • (1990) Am. J. Trop. Med. Hyg. , vol.43 , pp. 498-505
    • Zicker, F.1    Smith, P.G.2    Netto, J.C.3    Oliveira, R.M.4    Zicker, E.M.5
  • 62
    • 58849121536 scopus 로고    scopus 로고
    • Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy
    • Costa, G.C. et al. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J. Infect. Dis. 199, 451-454 (2009).
    • (2009) J. Infect. Dis. , vol.199 , pp. 451-454
    • Costa, G.C.1
  • 63
    • 77955120400 scopus 로고    scopus 로고
    • Chagas disease: Changes in knowledge and management
    • Lescure, F.X. et al. Chagas disease: changes in knowledge and management. Lancet Infect. Dis. 10, 556-570 (2010).
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 556-570
    • Lescure, F.X.1
  • 64
    • 29144486106 scopus 로고    scopus 로고
    • The complex pattern of SMAD signaling in the cardiovascular system
    • DOI 10.1016/j.cardiores.2005.07.007, PII S0008636305003731
    • Euler-Taimor, G. & Heger, J. The complex pattern of SMAD signaling in the cardiovascular system. Cardiovasc. Res. 69, 15-25 (2006). (Pubitemid 41814808)
    • (2006) Cardiovascular Research , vol.69 , Issue.1 , pp. 15-25
    • Euler-Taimor, G.1    Heger, J.2
  • 65
    • 20844441771 scopus 로고    scopus 로고
    • Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3
    • DOI 10.1161/01.CIR.0000147180.87553.79
    • Pokharel, S. et al. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3. Circulation 110, 3129-3135 (2004). (Pubitemid 39492009)
    • (2004) Circulation , vol.110 , Issue.19 , pp. 3129-3135
    • Pokharel, S.1    Van Geel, P.P.2    Sharma, U.C.3    Cleutjens, J.P.M.4    Bohnemeier, H.5    Tian, X.-L.6    Schunkert, H.7    Crijns, H.J.G.M.8    Paul, M.9    Pinto, Y.M.10
  • 66
    • 79957888881 scopus 로고    scopus 로고
    • Pivotal role of cardiomyocyte TGF-? signaling in the murine pathological response to sustained pressure overload
    • Koitabashi, N. et al. Pivotal role of cardiomyocyte TGF-? signaling in the murine pathological response to sustained pressure overload. J. Clin. Invest. 121, 2301-2312 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2301-2312
    • Koitabashi, N.1
  • 67
    • 71449100603 scopus 로고    scopus 로고
    • Strategies for TGF-beta modulation: A review of recent patents
    • Bonafoux, D. & Lee, W.C. Strategies for TGF-beta modulation: a review of recent patents. Expert Opin. Ther. Pat. 19, 1759-1769 (2009).
    • (2009) Expert Opin. Ther. Pat. , vol.19 , pp. 1759-1769
    • Bonafoux, D.1    Lee, W.C.2
  • 70
    • 79952051819 scopus 로고    scopus 로고
    • Current and emerging therapeutic options for the treatment of chronic chagasic cardiomyopathy
    • Muratore, C.A. & Baranchuk, A. Current and emerging therapeutic options for the treatment of chronic chagasic cardiomyopathy. Vasc. Health Risk Manag. 6, 593-601 (2010).
    • (2010) Vasc. Health Risk Manag. , vol.6 , pp. 593-601
    • Muratore, C.A.1    Baranchuk, A.2
  • 72
    • 65649117884 scopus 로고    scopus 로고
    • Amiodarone and itraconazole: A rational therapeutic approach for the treatment of chronic Chagas' disease
    • Paniz-Mondolfi, A.E., Pérez-Alvarez, A.M., Lanza, G., Márquez, E. & Concepción, J.L. Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas' disease. Chemotherapy 55, 228-233 (2009).
    • (2009) Chemotherapy , vol.55 , pp. 228-233
    • Paniz-Mondolfi, A.E.1    Pérez-Alvarez, A.M.2    Lanza, G.3    Márquez, E.4    Concepción, J.L.5
  • 73
    • 0037214476 scopus 로고    scopus 로고
    • 1 gene expression but not prevention of mitochondrial dysfunction
    • DOI 10.1124/jpet.102.043208
    • Card, J.W., Racz, W.J., Brien, J.F. & Massey, T.E. Attenuation of amiodaroneinduced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J. Pharmacol. Exp. Ther. 304, 277-283 (2003). (Pubitemid 36008939)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.304 , Issue.1 , pp. 277-283
    • Card, J.W.1    Racz, W.J.2    Brien, J.F.3    Massey, T.E.4
  • 74
    • 78650636036 scopus 로고    scopus 로고
    • Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro
    • Adesse, D., Azzam, E.M., Meirelles, M.d.e.N., Urbina, J.A. & Garzoni, L.R. Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro. Antimicrob. Agents Chemother. 55, 203-210 (2011).
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 203-210
    • Adesse, D.1    Azzam, E.M.2    De Meirelles, M.N.3    Urbina, J.A.4    Garzoni, L.R.5
  • 75
    • 79960539964 scopus 로고    scopus 로고
    • Off the beaten renin-angiotensin-aldosterone system pathway: New perspectives on antiproteinuric therapy
    • Gordon, J. & Kopp, J.B. Off the beaten renin-angiotensin-aldosterone system pathway: new perspectives on antiproteinuric therapy. Adv. Chronic Kidney Dis. 18, 300-311 (2011).
    • (2011) Adv. Chronic Kidney Dis. , vol.18 , pp. 300-311
    • Gordon, J.1    Kopp, J.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.