-
1
-
-
84872601225
-
-
World Health Organization. First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases
-
World Health Organization. First WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases http://www.gsk.com/media/downloads/WHO-report-on-NTD.PDF (2011).
-
(2011)
-
-
-
2
-
-
77956988584
-
The centennial of the discovery of Chagas disease: Facing the current challenges
-
Lannes-Vieira, J., de Araújo-Jorge, T.C., Soeiro, M.d.e.N., Gadelha, P. & Corrêa-Oliveira, R. The centennial of the discovery of Chagas disease: facing the current challenges. PLoS Negl. Trop. Dis. 4, e645 (2010).
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Lannes-Vieira, J.1
De Araújo-Jorge, T.C.2
De Soeiro, M.N.3
Gadelha, P.4
Corrêa-Oliveira, R.5
-
3
-
-
77950824213
-
Chagas disease
-
Rassi, A. Jr, Rassi, A. & Marin-Neto, J.A. Chagas disease. Lancet 375, 1388-1402 (2010).
-
(2010)
Lancet
, vol.375
, pp. 1388-1402
-
-
Rassi Jr., A.1
Rassi, A.2
Marin-Neto, J.A.3
-
4
-
-
68949212150
-
Chagas heart disease: Pathophysiologic mechanisms, prognostic factors and risk stratification
-
Rassi Jr, A., Rassi, A. & Marin-Neto, J.A. Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 152-158 (2009).
-
(2009)
Mem. Inst. Oswaldo Cruz
, vol.104
, Issue.SUPPL. 1
, pp. 152-158
-
-
Rassi Jr., A.1
Rassi, A.2
Marin-Neto, J.A.3
-
5
-
-
33947597320
-
Pathogenesis of chronic Chagas heart disease
-
DOI 10.1161/CIRCULATIONAHA.106.624296, PII 0000301720070306000009
-
Marin-Neto, J.A., Cunha-Neto, E., Maciel, B.C. & Simöes, M.V. Pathogenesis of chronic Chagas heart disease. Circulation 115, 1109-1123 (2007). (Pubitemid 46679556)
-
(2007)
Circulation
, vol.115
, Issue.9
, pp. 1109-1123
-
-
Marin-Neto, J.A.1
Cunha-Neto, E.2
Maciel, B.C.3
Simoes, M.V.4
-
6
-
-
79959793199
-
Antitrypanosomal therapy for chronic Chagas' disease
-
Bern, C. Antitrypanosomal therapy for chronic Chagas' disease. N. Engl. J. Med. 364, 2527-2534 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2527-2534
-
-
Bern, C.1
-
7
-
-
68949220484
-
The BENEFIT trial: Testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease
-
Marin-Neto, J.A. et al. The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 319-324 (2009).
-
(2009)
Mem. Inst. Oswaldo Cruz
, vol.104
, Issue.SUPPL. 1
, pp. 319-324
-
-
Marin-Neto, J.A.1
-
8
-
-
0025061465
-
-
New York Academy of Sciences, New York
-
Piez, K. & Sporn, M. Transforming Growth Factor-?s. Chemistry, Biology and Therapeutics, Vol. 593 (New York Academy of Sciences, New York, 1990).
-
(1990)
Transforming Growth Factor-?s. Chemistry, Biology and Therapeutics
, vol.593
-
-
Piez, K.1
Sporn, M.2
-
9
-
-
80052875424
-
TGF-? signaling in fibrosis
-
Biernacka, A., Dobaczewski, M. & Frangogiannis, N.G. TGF-? signaling in fibrosis. Growth Factors 29, 196-202 (2011).
-
(2011)
Growth Factors
, vol.29
, pp. 196-202
-
-
Biernacka, A.1
Dobaczewski, M.2
Frangogiannis, N.G.3
-
10
-
-
80052819014
-
Transforming growth factor (TGF)-? signaling in cardiac remodeling
-
Dobaczewski, M., Chen, W. & Frangogiannis, N.G. Transforming growth factor (TGF)-? signaling in cardiac remodeling. J. Mol. Cell. Cardiol. 51, 600-606 (2011).
-
(2011)
J. Mol. Cell. Cardiol.
, vol.51
, pp. 600-606
-
-
Dobaczewski, M.1
Chen, W.2
Frangogiannis, N.G.3
-
11
-
-
33646562542
-
The logic of TGFbeta signaling
-
Massagué, J. & Gomis, R.R. The logic of TGFbeta signaling. FEBS Lett. 580, 2811-2820 (2006).
-
(2006)
FEBS Lett.
, vol.580
, pp. 2811-2820
-
-
Massagué, J.1
Gomis, R.R.2
-
12
-
-
24944497786
-
Non-Smad TGF-beta signals
-
Moustakas, A. & Heldin, C.H. Non-Smad TGF-beta signals. J. Cell. Sci. 118, 3573-3584 (2005).
-
(2005)
J. Cell. Sci.
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
13
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
-
Bogdahn, U., Hau, P., Stockhammer, G., Venkataramana, N.K., Mahapatra, A.K., Suri, A. Targeted therapy for high-grade glioma with the TGF-beta2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro. Oncol. 13, 132-142 (2011).
-
(2011)
Neuro. Oncol.
, vol.13
, pp. 132-142
-
-
Bogdahn, U.1
Hau, P.2
Stockhammer, G.3
Venkataramana, N.K.4
Mahapatra, A.K.5
Suri, A.6
-
14
-
-
80355139007
-
The antisense oligonucleotide trabedersen (AP 12009) for the targeted inhibition of TGF-?2
-
Jaschinski, F., Rothhammer, T., Jachimczak, P., Seitz, C., Schneider, A. & Schlingensiepen, K.H. The antisense oligonucleotide trabedersen (AP 12009) for the targeted inhibition of TGF-?2. Curr. Pharm. Biotechnol. 12, 2203-2213 (2011).
-
(2011)
Curr. Pharm. Biotechnol.
, vol.12
, pp. 2203-2213
-
-
Jaschinski, F.1
Rothhammer, T.2
Jachimczak, P.3
Seitz, C.4
Schneider, A.5
Schlingensiepen, K.H.6
-
15
-
-
33645665682
-
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N- (tetrahydro-2H-pyran-4-yl)benzamide (GW788388): A potent, selective, and orally active transforming growth factor-beta type i receptor inhibitor
-
Gellibert, F. et al. Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl] pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. J. Med. Chem. 49, 2210-2221 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2210-2221
-
-
Gellibert, F.1
-
16
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
-
DOI 10.1124/mol.62.1.58
-
Laping, N.J. et al. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol. Pharmacol. 62, 58-64 (2002). (Pubitemid 34680516)
-
(2002)
Molecular Pharmacology
, vol.62
, Issue.1
, pp. 58-64
-
-
Laping, N.J.1
Grygielko, E.2
Mathur, A.3
Butter, S.4
Bomberger, J.5
Tweed, C.6
Martin, W.7
Fornwald, J.8
Lehr, R.9
Harling, J.10
Gaster, L.11
Callahan, J.F.12
Olson, B.A.13
-
17
-
-
40049099699
-
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis
-
DOI 10.1038/sj.ki.5002717, PII 5002717
-
Petersen, M. et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 73, 705-715 (2008). (Pubitemid 351323246)
-
(2008)
Kidney International
, vol.73
, Issue.6
, pp. 705-715
-
-
Petersen, M.1
Thorikay, M.2
Deckers, M.3
Van Dinther, M.4
Grygielko, E.T.5
Gellibert, F.6
De Gouville, A.C.7
Huet, S.8
Ten Dijke, P.9
Laping, N.J.10
-
18
-
-
80053585761
-
Induction of heart valve lesions by small-molecule ALK5 inhibitors
-
Anderton, M.J. et al. Induction of heart valve lesions by small-molecule ALK5 inhibitors. Toxicol. Pathol. 39, 916-924 (2011).
-
(2011)
Toxicol. Pathol.
, vol.39
, pp. 916-924
-
-
Anderton, M.J.1
-
19
-
-
35348940144
-
Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
-
Prud'homme, G.J. Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab. Invest. 87, 1077-1091 (2007).
-
(2007)
Lab. Invest.
, vol.87
, pp. 1077-1091
-
-
Prud'Homme, G.J.1
-
20
-
-
56949093019
-
Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy
-
Araújo-Jorge, T.C., Waghabi, M.C., Soeiro, M.d.e.N., Keramidas, M., Bailly, S. & Feige, J.J. Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine Growth Factor Rev. 19, 405-413 (2008).
-
(2008)
Cytokine Growth Factor Rev.
, vol.19
, pp. 405-413
-
-
Araújo-Jorge, T.C.1
Waghabi, M.C.2
De Soeiro, M.N.3
Keramidas, M.4
Bailly, S.5
Feige, J.J.6
-
21
-
-
0025741792
-
Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta)
-
Silva, J.S., Twardzik, D.R. & Reed, S.G. Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta). J. Exp. Med. 174, 539-545 (1991).
-
(1991)
J. Exp. Med.
, vol.174
, pp. 539-545
-
-
Silva, J.S.1
Twardzik, D.R.2
Reed, S.G.3
-
23
-
-
0037114922
-
Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy
-
DOI 10.1086/345882
-
Araújo-Jorge, T.C. et al. Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy. J. Infect. Dis. 186, 1823-1828 (2002). (Pubitemid 35463516)
-
(2002)
Journal of Infectious Diseases
, vol.186
, Issue.12
, pp. 1823-1828
-
-
Araujo-Jorge, T.C.1
Waghabi, M.C.2
Hasslocher-Moreno, A.M.3
Xavier, S.S.4
Higuchi, M.D.L.5
Keramidas, M.6
Bailly, S.7
Feige, J.-J.8
-
24
-
-
79958004980
-
Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease
-
Pérez, A.R. et al. Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease. J. Neuroimmunol. 235, 84-90 (2011).
-
(2011)
J. Neuroimmunol.
, vol.235
, pp. 84-90
-
-
Pérez, A.R.1
-
25
-
-
0034328991
-
Growth factors in the myocardium of patients with chronic chagasic cardiomyopathy
-
Reis, M.M., Higuchi, M.d.e.L., Aiello, V.D. & Benvenuti, L.A. [Growth factors in the myocardium of patients with chronic chagasic cardiomyopathy]. Rev. Soc. Bras. Med. Trop. 33, 509-518 (2000).
-
(2000)
Rev. Soc. Bras. Med. Trop.
, vol.33
, pp. 509-518
-
-
Reis, M.M.1
De Higuchi, M.L.2
Aiello, V.D.3
Benvenuti, L.A.4
-
26
-
-
72449171585
-
Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection
-
Waghabi, M.C. et al. Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection. Mem. Inst. Oswaldo Cruz 104, 1083-1090 (2009).
-
(2009)
Mem. Inst. Oswaldo Cruz
, vol.104
, pp. 1083-1090
-
-
Waghabi, M.C.1
-
27
-
-
68949219809
-
The effects of nitric oxide on the immune system during Trypanosoma cruzi infection
-
Gutierrez, F.R., Mineo, T.W., Pavanelli, W.R., Guedes, P.M. & Silva, J.S. The effects of nitric oxide on the immune system during Trypanosoma cruzi infection. Mem. Inst. Oswaldo Cruz 104 (suppl. 1), 236-245 (2009).
-
(2009)
Mem. Inst. Oswaldo Cruz
, vol.104
, Issue.SUPPL. 1
, pp. 236-245
-
-
Gutierrez, F.R.1
Mineo, T.W.2
Pavanelli, W.R.3
Guedes, P.M.4
Silva, J.S.5
-
28
-
-
79960364782
-
Exploring anti-TGF-? therapies in cancer and fibrosis
-
Hawinkels, L.J. & Ten Dijke, P. Exploring anti-TGF-? therapies in cancer and fibrosis. Growth Factors 29, 140-152 (2011).
-
(2011)
Growth Factors
, vol.29
, pp. 140-152
-
-
Hawinkels, L.J.1
Ten Dijke, P.2
-
29
-
-
79961139550
-
TGF-?/TGF-? receptor system and its role in physiological and pathological conditions
-
Santibañez, J.F., Quintanilla, M. & Bernabeu, C. TGF-?/TGF-? receptor system and its role in physiological and pathological conditions. Clin. Sci. 121, 233-251 (2011).
-
(2011)
Clin. Sci.
, vol.121
, pp. 233-251
-
-
Santibañez, J.F.1
Quintanilla, M.2
Bernabeu, C.3
-
30
-
-
0036719851
-
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin
-
Waghabi, M.C. et al. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. Infect. Immun. 70, 5115-5123 (2002).
-
(2002)
Infect. Immun.
, vol.70
, pp. 5115-5123
-
-
Waghabi, M.C.1
-
31
-
-
70350307193
-
Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease
-
Waghabi, M.C. et al. Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease. Antimicrob. Agents Chemother. 53, 4694-4701 (2009).
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 4694-4701
-
-
Waghabi, M.C.1
-
32
-
-
34547620907
-
SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion
-
DOI 10.1128/AAC.00022-07
-
Waghabi, M.C. et al. SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite cycle completion. Antimicrob. Agents Chemother. 51, 2905-2910 (2007). (Pubitemid 47206229)
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, Issue.8
, pp. 2905-2910
-
-
Waghabi, M.C.1
Keramidas, M.2
Calvet, C.M.3
Meuser, M.4
Soeiro, M.D.N.C.5
Mendonca-Lima, L.6
Araujo-Jorge, T.C.7
Feige, J.-J.8
Bailly, S.9
-
33
-
-
0028987602
-
The TGF beta superfamily in myocardium: Ligands, receptors, transduction, and function
-
Brand, T. & Schneider, M.D. The TGF beta superfamily in myocardium: ligands, receptors, transduction, and function. J. Mol. Cell. Cardiol. 27, 5-18 (1995).
-
(1995)
J. Mol. Cell. Cardiol.
, vol.27
, pp. 5-18
-
-
Brand, T.1
Schneider, M.D.2
-
34
-
-
33751259883
-
Upregulation of expression of sarcoplasmic reticulum by TGF-beta 1 in cultured rat cardiac myocytes
-
Kimura, H., Takemura, H., Imoto, K., Ohshika, H. & Mochizuki, Y. Upregulation of expression of sarcoplasmic reticulum by TGF-beta 1 in cultured rat cardiac myocytes. Am. J. Physiol. 272, H2639-H2644 (1997).
-
(1997)
Am. J. Physiol.
, vol.272
-
-
Kimura, H.1
Takemura, H.2
Imoto, K.3
Ohshika, H.4
Mochizuki, Y.5
-
35
-
-
0026475715
-
Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1
-
Roberts, A.B., Roche, N.S., Winokur, T.S., Burmester, J.K. & Sporn, M.B. Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1. J. Clin. Invest. 90, 2056-2062 (1992).
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 2056-2062
-
-
Roberts, A.B.1
Roche, N.S.2
Winokur, T.S.3
Burmester, J.K.4
Sporn, M.B.5
-
36
-
-
33645806742
-
Fibrosis in heart disease: Understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia
-
Khan, R. & Sheppard, R. Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia. Immunology 118, 10-24 (2006).
-
(2006)
Immunology
, vol.118
, pp. 10-24
-
-
Khan, R.1
Sheppard, R.2
-
37
-
-
0033813219
-
Induction of cardiac fibrosis by transforming growth factor-beta(1)
-
Lijnen, P.J., Petrov, V.V. & Fagard, R.H. Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol. Genet. Metab. 71, 418-435 (2000).
-
(2000)
Mol. Genet. Metab.
, vol.71
, pp. 418-435
-
-
Lijnen, P.J.1
Petrov, V.V.2
Fagard, R.H.3
-
38
-
-
33750490112
-
Angiotensin II stimulates apoptosis via TGF-beta1 signaling in ventricular cardiomyocytes of rat
-
DOI 10.1007/s00109-006-0090-0
-
Schröder, D., Heger, J., Piper, H.M. & Euler, G. Angiotensin II stimulates apoptosis via TGF-beta1 signaling in ventricular cardiomyocytes of rat. J. Mol. Med. 84, 975-983 (2006). (Pubitemid 44655875)
-
(2006)
Journal of Molecular Medicine
, vol.84
, Issue.11
, pp. 975-983
-
-
Schroder, D.1
Heger, J.2
Piper, H.M.3
Euler, G.4
-
39
-
-
0028783296
-
Induction of hypertrophic responsiveness to isoproterenol by TGF-beta in adult rat cardiomyocytes
-
Schlüter, K.D., Zhou, X.J. & Piper, H.M. Induction of hypertrophic responsiveness to isoproterenol by TGF-beta in adult rat cardiomyocytes. Am. J. Physiol. 269, C1311-C1316 (1995). (Pubitemid 3005892)
-
(1995)
The American journal of physiology
, vol.269
, Issue.51
-
-
Schluter, K.D.1
Zhou Xi-Juan2
Piper, H.M.3
-
40
-
-
0037023644
-
Autocrine regulation of myocyte Cx43 expression by VEGF
-
DOI 10.1161/01.RES.0000014823.75393.4D
-
Pimentel, R.C., Yamada, K.A., Kléber, A.G. & Saffitz, J.E. Autocrine regulation of myocyte Cx43 expression by VEGF. Circ. Res. 90, 671-677 (2002). (Pubitemid 34640885)
-
(2002)
Circulation Research
, vol.90
, Issue.6
, pp. 671-677
-
-
Pimentel, R.C.1
Yamada, K.A.2
Kleber, A.G.3
Saffitz, J.E.4
-
41
-
-
20444362700
-
Gap junctional communication in tissue inflammation and repair
-
DOI 10.1016/j.bbamem.2004.10.005, PII S0005273604002652
-
Chanson, M. et al. Gap junctional communication in tissue inflammation and repair. Biochim. Biophys. Acta 1711, 197-207 (2005). (Pubitemid 40799294)
-
(2005)
Biochimica et Biophysica Acta - Biomembranes
, vol.1711
, Issue.2 SPEC. ISS.
, pp. 197-207
-
-
Chanson, M.1
Derouette, J.-P.2
Roth, I.3
Foglia, B.4
Scerri, I.5
Dudez, T.6
Kwak, B.R.7
-
42
-
-
0032923777
-
Rearrangement of adherens junctions by transforming growth factor-beta1: Role of contraction
-
Hurst V, I.V., Goldberg, P.L., Minnear, F.L., Heimark, R.L. & Vincent, P.A. Rearrangement of adherens junctions by transforming growth factor-beta1: role of contraction. Am. J. Physiol. 276, L582-L595 (1999). (Pubitemid 29211360)
-
(1999)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.276
, Issue.4
-
-
Hurst IV, V.1
Goldberg, P.L.2
Minnear, F.L.3
Heimark, R.L.4
Vincent, P.A.5
-
43
-
-
77956627158
-
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction
-
Dobaczewski, M. et al. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ. Res. 107, 418-428 (2010).
-
(2010)
Circ. Res.
, vol.107
, pp. 418-428
-
-
Dobaczewski, M.1
-
44
-
-
79951471956
-
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
-
DosReis, G.A. Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease. Braz. J. Med. Biol. Res. 44, 84-90 (2011).
-
(2011)
Braz. J. Med. Biol. Res.
, vol.44
, pp. 84-90
-
-
Dosreis, G.A.1
-
45
-
-
0032779720
-
Local and systemic cytokine expression during experimental chronic Trypanosoma cruzi infection in a Cebus monkey model
-
DOI 10.1046/j.1365-3024.1999.00242.x
-
Samudio, M. et al. Local and systemic cytokine expression during experimental chronic Trypanosoma cruzi infection in a Cebus monkey model. Parasite Immunol. 21, 451-460 (1999). (Pubitemid 29401765)
-
(1999)
Parasite Immunology
, vol.21
, Issue.9
, pp. 451-460
-
-
Samudio, M.1
Montenegro-James, S.2
Kasamatsu, E.3
Cabral, M.4
Schinini, A.5
De Arias, A.R.6
James, M.A.7
-
46
-
-
35348907342
-
+ T cell dysfunction during experimental Trypanosoma cruzi infection
-
DOI 10.1002/eji.200737033
-
Martin, D.L., Postan, M., Lucas, P., Gress, R. & Tarleton, R.L. TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection. Eur. J. Immunol. 37, 2764-2771 (2007). (Pubitemid 47578295)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.10
, pp. 2764-2771
-
-
Martin, D.L.1
Postan, M.2
Lucas, P.3
Gress, R.4
Tarleton, R.L.5
-
47
-
-
0030048074
-
Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: Lack of association between susceptibility and type 2 cytokine production
-
Zhang, L. & Tarleton, R.L. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur. J. Immunol. 26, 102-109 (1996).
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 102-109
-
-
Zhang, L.1
Tarleton, R.L.2
-
48
-
-
84863669381
-
Oral administration of GW788388, an inhibitor of transforming growth factor-beta signaling, prevents heart fibrosis in Chagas disease
-
de Oliveira, F., Araújo-Jorge, T., de Souza, E., de Oliveira, G., Degrave, W., Feige, J. Oral administration of GW788388, an inhibitor of transforming growth factor-beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl. Trop. Dis. 6, e1696 (2012).
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
-
-
De Oliveira, F.1
Araújo-Jorge, T.2
De Souza, E.3
De Oliveira, G.4
Degrave, W.5
Feige, J.6
-
49
-
-
0036596094
-
Effects of immunomodulators on acute Trypanosoma cruzi infection in mice
-
Oz, H.S., Hughes, W.T., Thomas, E.K. & McClain, C.J. Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice. Med. Sci. Monit. 8, BR208-BR211 (2002). (Pubitemid 34694641)
-
(2002)
Medical Science Monitor
, vol.8
, Issue.6
-
-
Oz, H.S.1
Hughes, W.T.2
Thomas, E.K.3
McClain, C.J.4
-
50
-
-
61449103434
-
Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage
-
Medeiros, G.A. et al. Treatment of chronically Trypanosoma cruzi-infected mice with a CCR1/CCR5 antagonist (Met-RANTES) results in amelioration of cardiac tissue damage. Microbes Infect. 11, 264-273 (2009).
-
(2009)
Microbes Infect.
, vol.11
, pp. 264-273
-
-
Medeiros, G.A.1
-
51
-
-
67650650681
-
Short treatment with the tumour necrosis factor-alpha blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation
-
Pérez, A.R., Fontanella, G.H., Nocito, A.L., Revelli, S. & Bottasso, O.A. Short treatment with the tumour necrosis factor-alpha blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation. Clin. Exp. Immunol. 157, 291-299 (2009).
-
(2009)
Clin. Exp. Immunol.
, vol.157
, pp. 291-299
-
-
Pérez, A.R.1
Fontanella, G.H.2
Nocito, A.L.3
Revelli, S.4
Bottasso, O.A.5
-
52
-
-
84860396946
-
Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection
-
Cutrullis, R.A., Poklépovich, T.J., Postan, M., Freilij, H.L. & Petray, P.B. Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection. Int. Immunopharmacol. 11, 1024-1031 (2011).
-
(2011)
Int. Immunopharmacol.
, vol.11
, pp. 1024-1031
-
-
Cutrullis, R.A.1
Poklépovich, T.J.2
Postan, M.3
Freilij, H.L.4
Petray, P.B.5
-
53
-
-
0025864397
-
Chagas' cardioneuropathy: Effect of ganglioside treatment in chronic dysautonomic patients-A randomized, double-blind, parallel, placebo-controlled study
-
Iosa, D., Massari, D.C. & Dorsey, F.C. Chagas' cardioneuropathy: effect of ganglioside treatment in chronic dysautonomic patients-a randomized, double-blind, parallel, placebo-controlled study. Am. Heart J. 122, 775-785 (1991).
-
(1991)
Am. Heart J.
, vol.122
, pp. 775-785
-
-
Iosa, D.1
Massari, D.C.2
Dorsey, F.C.3
-
54
-
-
0032758981
-
Long-term treatment of chronic chagasic cardioneuropathy with a mixture of gangliosides: Effect on evolution of circulating antiGM1 antibodies
-
Mitelman, J., Gimenez, L., Aparicio, N.J. & Cortelezzi, M. Long-term treatment of chronic chagasic cardioneuropathy with a mixture of gangliosides: effect on evolution of circulating antiGM1 antibodies. J. Cardiol. 34, 189-197 (1999). (Pubitemid 29510334)
-
(1999)
Journal of Cardiology
, vol.34
, Issue.4
, pp. 189-197
-
-
Mitelman, J.1
Gimenez, L.2
Aparicio, N.J.3
Cortelezzi, M.4
-
55
-
-
80052147660
-
Gap junctions and chagas disease
-
Adesse, D. et al. Gap junctions and chagas disease. Adv. Parasitol. 76, 63-81 (2011).
-
(2011)
Adv. Parasitol.
, vol.76
, pp. 63-81
-
-
Adesse, D.1
-
56
-
-
0026583587
-
Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi
-
de Carvalho, A.C. et al. Gap junction distribution is altered between cardiac myocytes infected with Trypanosoma cruzi. Circ. Res. 70, 733-742 (1992).
-
(1992)
Circ. Res.
, vol.70
, pp. 733-742
-
-
De Carvalho, A.C.1
-
57
-
-
78249241534
-
Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication
-
Zhang, Y., Kanter, E.M. & Yamada, K.A. Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Cardiovasc. Pathol. 19, e233-e240 (2010).
-
(2010)
Cardiovasc. Pathol.
, vol.19
-
-
Zhang, Y.1
Kanter, E.M.2
Yamada, K.A.3
-
58
-
-
60249090231
-
Role of TGF-beta on cardiac structural and electrical remodeling
-
Ramos-Mondragón, R., Galindo, C.A. & Avila, G. Role of TGF-beta on cardiac structural and electrical remodeling. Vasc. Health Risk Manag. 4, 1289-1300 (2008).
-
(2008)
Vasc. Health Risk Manag.
, vol.4
, pp. 1289-1300
-
-
Ramos-Mondragón, R.1
Galindo, C.A.2
Avila, G.3
-
59
-
-
51749110724
-
Remodelling of gap junctions and connexin expression in diseased myocardium
-
Severs, N.J., Bruce, A.F., Dupont, E. & Rothery, S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc. Res. 80, 9-19 (2008).
-
(2008)
Cardiovasc. Res.
, vol.80
, pp. 9-19
-
-
Severs, N.J.1
Bruce, A.F.2
Dupont, E.3
Rothery, S.4
-
60
-
-
60649121513
-
Transforming growth factor beta 1 (TGFbeta1) gene polymorphisms and Chagas disease susceptibility in Peruvian and Colombian patients
-
Calzada, J.E., Beraún, Y., González, C.I. & Martín, J. Transforming growth factor beta 1 (TGFbeta1) gene polymorphisms and Chagas disease susceptibility in Peruvian and Colombian patients. Cytokine 45, 149-153 (2009).
-
(2009)
Cytokine
, vol.45
, pp. 149-153
-
-
Calzada, J.E.1
Beraún, Y.2
González, C.I.3
Martín, J.4
-
61
-
-
0025665195
-
Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy
-
Zicker, F., Smith, P.G., Netto, J.C., Oliveira, R.M. & Zicker, E.M. Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy. Am. J. Trop. Med. Hyg. 43, 498-505 (1990).
-
(1990)
Am. J. Trop. Med. Hyg.
, vol.43
, pp. 498-505
-
-
Zicker, F.1
Smith, P.G.2
Netto, J.C.3
Oliveira, R.M.4
Zicker, E.M.5
-
62
-
-
58849121536
-
Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy
-
Costa, G.C. et al. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J. Infect. Dis. 199, 451-454 (2009).
-
(2009)
J. Infect. Dis.
, vol.199
, pp. 451-454
-
-
Costa, G.C.1
-
63
-
-
77955120400
-
Chagas disease: Changes in knowledge and management
-
Lescure, F.X. et al. Chagas disease: changes in knowledge and management. Lancet Infect. Dis. 10, 556-570 (2010).
-
(2010)
Lancet Infect. Dis.
, vol.10
, pp. 556-570
-
-
Lescure, F.X.1
-
64
-
-
29144486106
-
The complex pattern of SMAD signaling in the cardiovascular system
-
DOI 10.1016/j.cardiores.2005.07.007, PII S0008636305003731
-
Euler-Taimor, G. & Heger, J. The complex pattern of SMAD signaling in the cardiovascular system. Cardiovasc. Res. 69, 15-25 (2006). (Pubitemid 41814808)
-
(2006)
Cardiovascular Research
, vol.69
, Issue.1
, pp. 15-25
-
-
Euler-Taimor, G.1
Heger, J.2
-
65
-
-
20844441771
-
Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3
-
DOI 10.1161/01.CIR.0000147180.87553.79
-
Pokharel, S. et al. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3. Circulation 110, 3129-3135 (2004). (Pubitemid 39492009)
-
(2004)
Circulation
, vol.110
, Issue.19
, pp. 3129-3135
-
-
Pokharel, S.1
Van Geel, P.P.2
Sharma, U.C.3
Cleutjens, J.P.M.4
Bohnemeier, H.5
Tian, X.-L.6
Schunkert, H.7
Crijns, H.J.G.M.8
Paul, M.9
Pinto, Y.M.10
-
66
-
-
79957888881
-
Pivotal role of cardiomyocyte TGF-? signaling in the murine pathological response to sustained pressure overload
-
Koitabashi, N. et al. Pivotal role of cardiomyocyte TGF-? signaling in the murine pathological response to sustained pressure overload. J. Clin. Invest. 121, 2301-2312 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2301-2312
-
-
Koitabashi, N.1
-
67
-
-
71449100603
-
Strategies for TGF-beta modulation: A review of recent patents
-
Bonafoux, D. & Lee, W.C. Strategies for TGF-beta modulation: a review of recent patents. Expert Opin. Ther. Pat. 19, 1759-1769 (2009).
-
(2009)
Expert Opin. Ther. Pat.
, vol.19
, pp. 1759-1769
-
-
Bonafoux, D.1
Lee, W.C.2
-
68
-
-
33847775958
-
Inhibition of ALK5 signaling induces physeal dysplasia in rats
-
DOI 10.1080/01926230701198469, PII 772663135
-
Frazier, K. et al. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Toxicol. Pathol. 35, 284-295 (2007). (Pubitemid 46393081)
-
(2007)
Toxicologic Pathology
, vol.35
, Issue.2
, pp. 284-295
-
-
Frazier, K.1
Thomas, R.2
Scicchitano, M.3
Mirabile, R.4
Boyce, R.5
Zimmerman, D.6
Grygielko, E.7
Nold, J.8
DeGouville, A.-C.9
Huet, S.10
Laping, N.11
Gellibert, F.12
-
69
-
-
0035834818
-
Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice
-
Mallat, Z. et al. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ. Res. 89, 930-934 (2001). (Pubitemid 34627899)
-
(2001)
Circulation Research
, vol.89
, Issue.10
, pp. 930-934
-
-
Mallat, Z.1
Gojova, A.2
Marchiol-Fournigault, C.3
Esposito, B.4
Kamate, C.5
Merval, R.6
Fradelizi, D.7
Tedgui, A.8
-
70
-
-
79952051819
-
Current and emerging therapeutic options for the treatment of chronic chagasic cardiomyopathy
-
Muratore, C.A. & Baranchuk, A. Current and emerging therapeutic options for the treatment of chronic chagasic cardiomyopathy. Vasc. Health Risk Manag. 6, 593-601 (2010).
-
(2010)
Vasc. Health Risk Manag.
, vol.6
, pp. 593-601
-
-
Muratore, C.A.1
Baranchuk, A.2
-
71
-
-
32344435160
-
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole
-
DOI 10.1021/jm050691f
-
Benaim, G. et al. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. J. Med. Chem. 49, 892-899 (2006). (Pubitemid 43221637)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.3
, pp. 892-899
-
-
Benaim, G.1
Sanders, J.M.2
Garcia-Marchan, Y.3
Colina, C.4
Lira, R.5
Caldera, A.R.6
Payares, G.7
Sanoja, C.8
Burgos, J.M.9
Leon-Rossell, A.10
Concepcion, J.L.11
Schijman, A.G.12
Levin, M.13
Oldfield, E.14
Urbina, J.A.15
-
72
-
-
65649117884
-
Amiodarone and itraconazole: A rational therapeutic approach for the treatment of chronic Chagas' disease
-
Paniz-Mondolfi, A.E., Pérez-Alvarez, A.M., Lanza, G., Márquez, E. & Concepción, J.L. Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas' disease. Chemotherapy 55, 228-233 (2009).
-
(2009)
Chemotherapy
, vol.55
, pp. 228-233
-
-
Paniz-Mondolfi, A.E.1
Pérez-Alvarez, A.M.2
Lanza, G.3
Márquez, E.4
Concepción, J.L.5
-
73
-
-
0037214476
-
1 gene expression but not prevention of mitochondrial dysfunction
-
DOI 10.1124/jpet.102.043208
-
Card, J.W., Racz, W.J., Brien, J.F. & Massey, T.E. Attenuation of amiodaroneinduced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J. Pharmacol. Exp. Ther. 304, 277-283 (2003). (Pubitemid 36008939)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.304
, Issue.1
, pp. 277-283
-
-
Card, J.W.1
Racz, W.J.2
Brien, J.F.3
Massey, T.E.4
-
74
-
-
78650636036
-
Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro
-
Adesse, D., Azzam, E.M., Meirelles, M.d.e.N., Urbina, J.A. & Garzoni, L.R. Amiodarone inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly in vitro. Antimicrob. Agents Chemother. 55, 203-210 (2011).
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 203-210
-
-
Adesse, D.1
Azzam, E.M.2
De Meirelles, M.N.3
Urbina, J.A.4
Garzoni, L.R.5
-
75
-
-
79960539964
-
Off the beaten renin-angiotensin-aldosterone system pathway: New perspectives on antiproteinuric therapy
-
Gordon, J. & Kopp, J.B. Off the beaten renin-angiotensin-aldosterone system pathway: new perspectives on antiproteinuric therapy. Adv. Chronic Kidney Dis. 18, 300-311 (2011).
-
(2011)
Adv. Chronic Kidney Dis.
, vol.18
, pp. 300-311
-
-
Gordon, J.1
Kopp, J.B.2
|