Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways

Circulation Research

Volumn 105, Issue 11, 2009, Pages 1149-1158

  Honsho, Shoken ^a   Nishikawa, Susumu ^a   Amano, Katsuya ^a   Zen, Kan ^a   Adachi, Yasushi ^b   Kishita, Eigo ^a   Matsui, Akihiro ^a   Katsume, Asako ^a   Yamaguchi, Shinichiro ^a   Nishikawa, Kenichiro ^c   Isoda, Kikuo ^c   Riches, David W H ^d   Matoba, Satoaki ^a   Okigaki, Mitsuhiko ^a   Matsubara, Hiroaki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Akt; Hypertrophy; Insulin like growth factor 1; Interleukin 1; JNK

Indexed keywords

CASPASE 3; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; STAT5 PROTEIN; INTERLEUKIN 1 RECEPTOR; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL SIZE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DNA MICROARRAY; ENZYME ACTIVITY; FIBROSING ALVEOLITIS; GENE CONTROL; GENETIC TRANSCRIPTION; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART VENTRICLE PRESSURE; HEART WEIGHT; IMMUNOGLOBULIN PRODUCTION; MOUSE; MUSCLE STRETCHING; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS; ANIMAL; APOPTOSIS; GENETICS; HEART MUSCLE FIBROSIS; MECHANICAL STRESS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ENDOMYOCARDIAL FIBROSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYPERTROPHY, LEFT VENTRICULAR; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1BETA; JANUS KINASE 2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, MUTANT STRAINS; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; STRESS, MECHANICAL; VENTRICULAR PRESSURE;

EID: 73349089976     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.208199     Document Type: Article

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